Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Neutralizing Interleukin (IL)-6 [Phase 2]
A Phase 2 clinical trial evaluating a neutralizing interleukin-6 agent for major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Physical Activity-based Intervention in Depressed Patients: Clinical, Neurophysiological, Epigenetic and Metabolic Correlates [NA]
This clinical trial investigates a physical activity-based intervention for adults with Major Depressive Disorder, examining clinical outcom…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Personalized Mobile Cognitive Behavioral Therapy Application [NA]
A personalized mobile cognitive behavioral therapy application is being evaluated in a recruiting clinical trial for anxiety disorders, depr…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study) [Phase 2]
A Phase 2 trial (BUOY-1) is evaluating the efficacy and safety of SPT-300 (GlyphAllo) for major depressive disorder with or without anxious …
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: An Open-Label Extension Study to Evaluate the Safety and Tolerability of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 OLE Study) [Phase 2]
This is an open-label extension study in Phase 2 evaluating the safety and tolerability of SPT-300 (GlyphAllo) in adults with major depressi…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Elucidating the Relevance of the Psychedelic Experience to Psilocybin's Anti-Anhedonic Effects [Phase 1]
This Phase 1 trial at the Medical University of Vienna is exploring how the psychedelic experience from psilocybin relates to its anti-anhed…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Nutritional Intervention for College Students With Depression [NA]
A clinical trial is currently recruiting college students with major depressive disorder to assess a nutritional intervention for depressive…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease [Phase 2]
Ongoing Phase 2 clinical trial evaluating probiotic treatment for depression and associated mood disorders in Parkinson disease; the study i…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 double-blind, placebo-controlled trial in adults with major depressive disorder is currently recruiting, sponsored by Supernus Pha…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts [Phase 4]
A Phase 4 clinical trial is investigating whether the kappa opioid receptor mediates ketamine's ability to reduce suicidal thoughts in indiv…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Social Media Concerns Related to Emotional Experiences in Naturalistic Settings (SCREENS)
The update describes a naturalistic clinical study at University of Texas Southwestern Medical Center examining how social media experiences…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Technology dRiven Enhancement to Engage & Connect [NA]
A clinical trial update from Weill Medical College of Cornell University indicates a technology-driven enhancement study for depression that…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Internet-based Mindfulness-based Training (iMBT) for People With Depression [NA]
This entry reports the completion of a clinical trial evaluating Internet-based Mindfulness-based Training (iMBT) for people with depression…
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CLINICAL_TRIALS trial_result · 2026-03-23Clinical Trial Update: Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms [NA]
A completed trial evaluated the effectiveness of a smartphone-delivered cognitive behavioral therapy program for adults with psoriasis and c…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study of Brenipatide in Adult Participants With Major Depressive Disorder [Phase 3]
A Phase 3 trial evaluating Brenipatide for major depressive disorder is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder [Phase 2]
Phase 2 clinical trial update for oral Icalcaprant in adults with Major Depressive Disorder, assessing change in disease activity and advers…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Home-Based tDCS Treatment Of Major Depressive Disorder [NA]
An ongoing clinical trial is evaluating home-based transcranial direct current stimulation for major depressive disorder; recruitment is cur…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression [Phase 1]
This Phase 1 trial investigates whether gamma oscillations can predict response to ketamine therapy in treatment-resistant depression. The s…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Mentalizing and Epistemic Trust in Patients With Anxiety and Depression. [NA]
A clinical trial investigating mentalizing and epistemic trust in patients with anxiety disorders and depression is currently recruiting, sp…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression [Phase 4]
This is a Phase 4 clinical trial update from Goethe University examining mechanisms of change across pharmacological, psychological, and com…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Technology-assisted Methods to Advance Suicide Prevention Among Youth in Colombia [NA]
A Brown University-led clinical trial in Colombia is evaluating technology-assisted methods to prevent suicide among youths. The study focus…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Brain Imaging of Cognition Inn Schizophrenia and Depression
A recruiting clinical trial at The Royal Ottawa Mental Health Centre is studying brain imaging and cognition in individuals with schizophren…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome [NA]
Northwestern University reports a trial update on co-designing and evaluating additional Mothers and Babies program content for expectant an…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start [NA]
A clinical trial update indicates that an Internet-Based Cognitive Behavioral Therapy program for maternal depression is currently recruitin…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Sham-Controlled Rapid-Acting Neuromodulation for Depression [NA]
A clinical trial update describes a sham-controlled, rapid-acting neuromodulation study for major depressive disorder. Recruitment has not y…