Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion [Phase 2, Phase 3]
This document provides a trial update for a Phase 2/Phase 3 study of Optimized Neuroplasticity-Enhanced Depression Transcranial Magnetic Sti…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment [NA]
A Mayo Clinic-sponsored clinical trial evaluating a virtual reality intervention to reduce psychological symptoms in cancer patients undergo…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: REstoring Mental Health Through COmmUnity-based Psychological Services in New York City [NA]
A George Washington University–sponsored clinical trial in New York City is recruiting participants to study the effectiveness of community-…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder [Phase 2]
A Phase 2 clinical trial update describing the plan to evaluate the efficacy and safety of SP-624 in adults with major depressive disorder, …
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Group-Based Acceptance and Commitment Therapy Versus Active Control in University Students With Emotional Symptoms [NA]
This clinical trial compares group-based Acceptance and Commitment Therapy to an active control in university students with emotional sympto…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD) [Phase 2]
Phase 2 long-term safety study of BHV-7000 in adults with Major Depressive Disorder completed.
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode [Phase 2]
Phase 2 trial RESIST evaluating MAP4343 in antidepressant non-responders with a major depressive episode has completed.
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Mindfulness Engaged Neurostimulation for Depression [Phase 2]
Phase 2 clinical trial of Mindfulness Engaged Neurostimulation for depression is currently active but not recruiting at University of Califo…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents [NA]
The clinical trial investigating brain insulin resistance as a feature of depression in adolescents has completed.
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Oncologic Surgery [NA]
The study evaluated behavioral activation and medication optimization to improve perioperative mental health in older adults undergoing canc…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Comparison of the Efficacy of Transcranial Direct Current Stimulation at Home Versus in Hospital Settings in Patients With Depressive Episodes [NA]
The document outlines a clinical trial comparing home-delivered versus hospital-delivered transcranial direct current stimulation for depres…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV [Phase 2]
Phase 2 trial comparing pramipexole versus escitalopram for major depressive disorder with comorbid mild neurocognitive disorder in people w…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Positive Affect Treatment for Adolescents With Early Life Adversity [NA]
Recruitment is ongoing for a clinical study evaluating Positive Affect Treatment in adolescents with early life adversity and depression.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Functional Magnetic Resonance Imaging Study of Inhibitory Control in Bipolar Disorder and Major Depressive Disorder [NA]
This is an update on a functional MRI study examining inhibitory control in people with Bipolar Disorder and Major Depressive Disorder, spon…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Cognitive Behavior Therapy in Psychiatric Inpatient Care [NA]
A clinical trial is evaluating Cognitive Behavior Therapy in psychiatric inpatient care for depression and anxiety disorders. The study is c…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
This entry describes a real-world clinical trial evaluating esketamine nasal spray for treatment-resistant depression, currently recruiting …
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation [NA]
This clinical trial update reports posted results from a dose-response study of accelerated transcranial magnetic stimulation for treatment-…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Prevention of Mother-to-child Transmission (PMTCT) Among Women Experiencing Depression in Malawi [NA]
This Malawi clinical trial is examining strategies to prevent mother-to-child transmission of HIV among pregnant women experiencing depressi…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Positive Minds Strong Bodies Implementation [NA]
Massachusetts General Hospital completed and posted results for the Positive Minds Strong Bodies trial. The study targeted depression and an…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study
A real-world study update analyzing the therapeutic and clinical profile of cannabinoid treatments for chronic pain, depression, and anxiety…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Randomized Neuroimaging Trial of Psilocybin in Depression [Phase 2]
A Phase 2 randomized neuroimaging trial evaluating psilocybin for depressive disorders, currently recruiting at Sunnybrook Health Sciences C…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: More Individualized Care: Assessment and Recovery Through Engagement [NA]
A completed Kaiser Permanente clinical trial evaluating assessment and recovery through engagement for depression, anxiety, opioid use disor…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment [NA]
This clinical trial update describes the early development and initial testing of a short digital intervention for patients on waiting lists…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: MicroRNA Correlates of Childhood Maltreatment and Suicidality
A University of Alabama at Birmingham study is investigating microRNA links to childhood maltreatment and suicidality in individuals with ma…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating psilocybin-assisted therapy for major depressive disorder in patients with non-small cell lung cancer. The…