Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Natural History of Depression, Bipolar Disorder and Suicide Risk
This document describes an ongoing NIMH-sponsored clinical research study characterizing the natural history of depression, bipolar disorder…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD [NA]
This clinical trial, sponsored by Weill Medical College of Cornell University, is recruiting to test a primary care-based psychosocial inter…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression : A Multicenter Randomized Controlled Trial [Phase 2]
Phase 2 multicenter randomized trial assessing sertraline plus Lactobacillus crispatus probiotic for adolescents with major depressive disor…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Sleep Mechanisms Of Regulating Emotions [NA]
A Stanford University study is recruiting to investigate how sleep mechanisms influence emotion regulation. Participants have insomnia or de…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Precarity and Reduction of Its Impact on the Mental Health of Health Students [NA]
A France-based clinical trial investigates how precarity affects mental health, including depression and quality of life, among health scien…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Clinical Validation of Samsung Smartwatch
A clinical trial validating the Samsung smartwatch for assessment/monitoring of mental health conditions, focusing on major depressive disor…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI
Clinical trial NCT07529886 from Guy's and St Thomas' NHS Foundation Trust investigates symptoms of anxiety and depression and shared decisio…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Sleep to Reduce Incident Depression Effectively in Peripartum [Phase 2]
A Phase 2 clinical trial sponsored by Henry Ford Health System is evaluating whether sleep interventions can reduce the onset of depression …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response [Phase 2]
Phase 2 ACP-211 monotherapy for major depressive disorder is currently recruiting, including treatment-resistant cases. The sponsor is ACADI…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies [Phase 2]
Phase 2 clinical trial evaluating psilocybin therapy for anxiety and depression in patients with metastatic solid tumors or incurable hemato…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Peer-Delivered Behavioral Activation in a CCBHC [NA]
Wayne State University is recruiting for a clinical trial evaluating peer-delivered behavioral activation in a certified community behaviora…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update investigating the antidepressant effects of 2R,6R-hydroxynorketamine (HNK) as a glutamate-release enhancer for…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole [NA]
This clinical trial update investigates the neurobiological mechanisms of pathological rumination in major depressive disorder and assesses …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS) [NA]
A clinical trial evaluating how electroconvulsive therapy or magnetic seizure therapy affects frontotemporal brain function in major depress…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2) [NA]
Be Well at Work-Plus is a clinical trial evaluating a depression and physical activity intervention for hospital service workers. The study …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore [NA]
Registry update for a National University of Singapore study evaluating internet-based cognitive behavioral therapy for mild-to-moderate dep…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Smoking Cessation for Depressed Smokers [Phase 1, Phase 2]
An ongoing Phase 1/2 trial at MD Anderson Cancer Center is exploring smoking cessation in individuals with depression. The study is currentl…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Bright Light Therapy for Depressed Geriatric Inpatients [Phase 2]
A Phase 2 clinical trial evaluating bright light therapy for unipolar depression in geriatric inpatients is currently enrolling by invitatio…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors [Phase 2]
Phase 2 trial evaluating psilocybin-assisted psychotherapy for depression and anxiety in cancer survivors, currently recruiting.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy [Phase 2]
A Phase 2 trial evaluating psilocybin-assisted psychotherapy for depression and anxiety in patients with advanced cancer on maintenance ther…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Sleep Health in U.S. Marines [Phase 2]
Phase 2 clinical trial evaluating sleep health among U.S. Marines, with attention to depression and suicidality.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3) [NA]
A status update on the Be Well at Work-Plus program’s Aim 3, evaluating a depression-focused intervention that includes physical activity fo…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Sleep and Circadian Interventions for College Students at High Risk of Suicide [NA]
A University of Pittsburgh trial is testing sleep and circadian interventions for college students at high risk of suicide; the study is cur…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" [Phase 3]
This entry describes a Phase 3 clinical trial evaluating CYB003, a deuterated psilocin analog, for Major Depressive Disorder, which is curre…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department [Phase 1]
Phase 1 study assessing the feasibility and safety of ketamine for patients with suicidality presenting to the emergency department.