Liver Cirrhosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2023-05-24Clinical Trial Update: Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development [Phase 2, Phase 3]
A Phase 2/3 trial evaluated simvastatin plus rifaximin in decompensated cirrhosis to prevent acute-on-chronic liver failure (ACLF).
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CLINICAL_TRIALS trial_result · 2023-05-23Clinical Trial Update: Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis [Phase 3]
Phase 3 trial comparing phlebotomy plus lifestyle and diet advice versus lifestyle and diet advice alone in patients with dysmetabolic liver…
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FDA approval · 2023-05-17FDA Approved: SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
FDA approved a supplemental application for Sun Pharmaceutical's spironolactone and hydrochlorothiazide combination product. The submission …
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FDA approval · 2023-05-10FDA Approved: FUROSEMIDE — Supplemental Application (Hikma Pharmaceuticals USA Inc.)
FDA approved a supplemental application for furosemide submitted by Hikma Pharmaceuticals USA Inc.
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CLINICAL_TRIALS trial_result · 2023-05-03Clinical Trial Update: Growth Hormone Therapy in Liver Cirrhosis [Phase 2, Phase 3]
Clinical trial update on Growth Hormone Therapy for liver cirrhosis (Phase 2/Phase 3) has been completed.
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CLINICAL_TRIALS trial_result · 2023-04-13Clinical Trial Update: Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial comparing allopurinol to atorvastatin for preventing complications in liver cirrhosis and hepatic encephalo…
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CLINICAL_TRIALS trial_result · 2023-04-11Clinical Trial Update: Polidocanol Foam in Hemorrhoidal Disease in Patients With Liver Cirrhosis [Phase 2, Phase 3]
A clinical trial update for polidocanol foam in hemorrhoidal disease in patients with liver cirrhosis, spanning Phase 2 and Phase 3.
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CLINICAL_TRIALS trial_result · 2023-04-10Clinical Trial Update: A Phase II Open-label Single-arm Study to Evaluate the Efficacy and Safety of ADSCs in Subjects With Liver Cirrhosis [Phase 2]
Phase II open-label single-arm study assessing adipose-derived stem cells (ADSCs) for efficacy and safety in liver cirrhosis.
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CLINICAL_TRIALS trial_result · 2023-03-09Clinical Trial Update: Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis [Phase 4]
Phase 4 trial of obeticholic acid in primary biliary cholangitis was terminated; results posted in 2023.
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FDA approval · 2023-02-17FDA Approved: SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE — Supplemental Application (Mylan Pharmaceuticals Inc.)
FDA approved a supplemental application for the generic Spironolactone and Hydrochlorothiazide from Mylan Pharmaceuticals Inc., a combinatio…
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CLINICAL_TRIALS trial_result · 2023-01-13Clinical Trial Update: Statins for Prevention of Disease Progression and Hospitalization in Liver Cirrhosis [Phase 4]
Phase 4 trial update on statins for prevention of disease progression and hospitalization in liver cirrhosis; the study is terminated.
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FDA label_change · 2023-01-09FDA Approved: TERLIVAZ — Supplemental Application (Mallinckrodt Hospital Products Inc.)
FDA approved a supplemental application for Terlivaz (terlipressin) by Mallinckrodt Hospital Products Inc., resulting in changes to labeling…
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FDA approval · 2022-12-16FDA Approved: FUROSEMIDE — Original Application (Lifestar Pharma LLC)
FDA approved Lifestar Pharma LLC's original application for furosemide, authorizing the generic version of the diuretic for its labeled indi…
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CLINICAL_TRIALS trial_result · 2022-12-07Clinical Trial Update: Research on Optimal Strategy of Hypoglycemic Therapy for Cirrhosis With Diabetes [Phase 3]
Phase 3 trial investigating optimal hypoglycemic therapy strategy in patients with liver cirrhosis and diabetes; status not yet determined.
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FDA approval · 2022-10-24FDA Approved: METOLAZONE — Original Application (Ingenus Pharmaceuticals LLC)
FDA approves Metolazone via Original Application for a generic version by Ingenus Pharmaceuticals LLC. The approval supports its use for ede…
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CLINICAL_TRIALS trial_result · 2022-10-07Clinical Trial Update: Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period [Phase 1, Phase 2]
A mixed Phase 1/2 clinical trial evaluating the relationship between serum vitamin D and outcomes after liver transplantation in cirrhotic p…
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CLINICAL_TRIALS trial_result · 2022-09-27Clinical Trial Update: Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitis [Phase 1, Phase 2]
A terminated Phase 1/2 clinical trial evaluating probiotics for non-alcoholic fatty liver disease and steatohepatitis; results have been pos…
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CLINICAL_TRIALS trial_result · 2022-09-06Clinical Trial Update: Study of Obeticholic Acid (OCA) Evaluating Pharmacokinetics and Safety in Participants With Primary Biliary Cholangitis (PBC) and Hepatic Impairment [Phase 4]
A Phase 4 clinical trial studying the pharmacokinetics and safety of obeticholic acid in participants with primary biliary cholangitis and h…
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CLINICAL_TRIALS trial_result · 2022-08-31Clinical Trial Update: Prophylactic Antibiotics in Admitted Cirrhotics [Phase 4]
Phase 4 trial update on prophylactic antibiotics in admitted cirrhotics; completed with posted results.
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FDA approval · 2022-08-04FDA Approved: BUMETANIDE — Original Application (Novadoz Pharmaceuticals LLC)
FDA approves the original ANDA for bumetanide (generic) by Novadoz Pharmaceuticals LLC for use in edema associated with congestive heart fai…
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CLINICAL_TRIALS trial_result · 2022-08-01Clinical Trial Update: Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1) [NA]
Completed pragmatic trial evaluating methods to improve communication about serious illness; results have been posted (2022-08-01).
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CLINICAL_TRIALS trial_result · 2022-07-27Clinical Trial Update: Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation [Phase 3]
A Phase 3 trial evaluating granulocyte-colony stimulating factor as an optimizing therapy for pediatric liver transplantation has been compl…
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CLINICAL_TRIALS trial_result · 2022-04-20Clinical Trial Update: Study to Investigate the Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination for 12 Weeks in Adults With Chronic HCV Infection and Compensated Cirrhosis [Phase 3]
Phase 3 trial evaluating Sofosbuvir/Velpatasvir fixed-dose combination for 12 weeks in adults with chronic Hepatitis C infection and compens…
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FDA approval · 2022-04-12FDA Approved: FUROSEMIDE — Supplemental Application (Phlow Corporation)
FDA granted a supplemental approval for Furosemide by Phlow Corporation under the existing NDA; the snippet does not specify the exact natur…
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CLINICAL_TRIALS withdrawal · 2022-02-08Clinical Trial Update: Rifaximin Versus Lactulose in Renal Failure [Phase 4]
Phase 4 trial comparing rifaximin to lactulose in patients with liver cirrhosis and renal failure was withdrawn.