Leptomeningeal Metastasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Intrathecal Double Checkpoint Inhibition [Phase 1]
This Phase 1 clinical trial from the University of Zurich investigates intrathecal double checkpoint inhibition for leptomeningeal metastasi…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases [Phase 1]
A Phase I pilot safety and feasibility study of the SV-BR-1-GM whole-cell vaccine for solid tumors with CNS metastases (brain metastases and…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors [Phase 1, Phase 2]
ClinicalTrials.gov update describes a Phase 1/2 study evaluating an immune checkpoint inhibitor in combination with intrathecal pemetrexed f…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer [NA]
A recruiting clinical trial evaluating adding pemetrexed to a third-generation EGFR tyrosine kinase inhibitor (e.g., osimertinib) versus the…
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CLINICAL_TRIALS withdrawal · 2025-09-26Clinical Trial Update: Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis. [NA]
Clinical trial investigating exosome analyses in cerebrospinal fluid for breast cancer patients with suspected leptomeningeal metastasis has…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases [Phase 1, Phase 2]
This is a two-cohort Phase 1/Phase 2 study evaluating SHR-A1811 for HER2-positive breast cancer with brain metastases.
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases [Phase 1, Phase 2]
Phase I/II study investigating intrathecal administration of trastuzumab deruxtecan (T-DXd) via Ommaya for HER2-expressing breast cancer wit…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial evaluating multiple-dose intraventricular administration of Rhenium-186 NanoLiposome for leptomeningeal metastasis. T…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases [Phase 4]
A Phase 4 trial evaluating firmonertinib in combination with intrathecal injection for EGFR-mutant non-small cell lung cancer with leptomeni…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Pembrolizumab And Lenvatinib In Leptomeningeal Metastases [Phase 2]
This clinical trial update reports that the Phase 2 study of pembrolizumab and lenvatinib in leptomeningeal metastasis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease [Phase 2]
Phase 2 results update for DS-8201a (trastuzumab deruxtecan) in advanced HER2-positive breast cancer, including patients with brain metastas…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center Study
This clinical trial update describes a dual-center study evaluating an AI-based ultrasound model to predict intracranial pressure and progno…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
An early-phase clinical trial at Guangzhou Medical University is evaluating intrathecal delivery of a PD-1/VEGF bispecific antibody in combi…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial is investigating intrathecal administration of a PD-1/CTLA-4 bispecific antibody with pemetrexed for leptomeninge…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating intrathecal dual PD-1 and CTLA-4 checkpoint inhibition with pemetrexed for leptomeningeal metastasi…
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CLINICAL_TRIALS trial_result · 2025-05-04Clinical Trial Update: Intrathecal Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating intrathecal pemetrexed for leptomeningeal metastasis has completed. The study was sponsored by The Fir…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Clinical trial update for a real-world study in China assessing treatment of leptomeningeal metastasis from non-small cell lung cancer; the …
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CLINICAL_TRIALS research · 2025-04-15Clinical Trial Update: A Clinical Study of Furmonertinib in the Treatment of EGFR-Mutated NSCLC With Leptomeningeal Metastases
Clinical trial update for furmonertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis; the study is currently ac…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis [NA]
A clinical trial is investigating proton craniospinal irradiation for leptomeningeal metastasis and is currently recruiting.
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CLINICAL_TRIALS research · 2025-04-03Clinical Trial Update: Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) [Phase 1]
Phase 1 clinical trial evaluating intrathecal administration of a PD-1 antibody for leptomeningeal metastasis from metastatic solid tumors. …
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases [Phase 2]
A Phase 2 trial is evaluating intraventricular pemetrexed plus nivolumab for refractory non-squamous non-small cell lung cancer with leptome…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases [Phase 1]
Update on a Phase 1 clinical trial evaluating intraventricular administration of Rhenium-186 NanoLiposome for leptomeningeal metastasis, spo…
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CLINICAL_TRIALS research · 2025-03-06Clinical Trial Update: Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis [NA]
A ClinicalTrials.gov entry describes a study evaluating high-dose furmonertinib in combination with bevacizumab and pemetrexed for EGFR-muta…
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CLINICAL_TRIALS trial_result · 2025-02-11Clinical Trial Update: CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease [NA]
This entry describes a recruiting clinical trial evaluating CSF analysis in patients with EGFR-mutant non-small cell lung cancer and leptome…
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CLINICAL_TRIALS research · 2025-01-09Clinical Trial Update: Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs [NA]
Clinical trial update indicates Ivonescimab (AK112) combined with chemotherapy for leptomeningeal metastasis in non-small cell lung cancer a…