Leptomeningeal Metastasis
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CLINICAL_TRIALS trial_result · 2024-12-30Clinical Trial Update: Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation [Phase 2]
A Phase 2 trial of TY-9591 in non-small cell lung cancer with EGFR activating mutation and brain or leptomeningeal metastases has completed.
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Retrospective Study on Leptomeningeal Metastasis of Solid Tumors
This document describes a retrospective study on leptomeningeal metastasis from solid tumors. The study is currently enrolling by invitation…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy and safety of intrathecal thiotepa in combination with methotrexate for leptomeningeal m…
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CLINICAL_TRIALS trial_result · 2024-06-06Clinical Trial Update: Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
The ClinicalTrials.gov record indicates the study evaluating a microfluidic diagnostic device for leptomeningeal metastasis in breast cancer…
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI [Phase 2]
Phase 2 trial assessing double-dose third-generation EGFR-TKI with intrathecal pemetrexed versus double-dose third-generation EGFR-TKI in le…
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CLINICAL_TRIALS research · 2024-05-28Clinical Trial Update: Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer [Phase 1]
A Phase 1 clinical trial update evaluating safety and efficacy of combining whole-brain low-dose radiotherapy with a PD-1 inhibitor and intr…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
This ClinicalTrials.gov entry reports that the University of Zurich is recruiting participants for a study evaluating standardized clinical …
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir
This clinical trial tests intraventricular pemetrexed disodium delivered via an Ommaya reservoir for leptomeningeal metastasis and lung canc…
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CLINICAL_TRIALS trial_result · 2022-05-23Clinical Trial Update: Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating an immune checkpoint inhibitor combined with recombinant human endostatin for leptomeningeal metastasis fr…
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CLINICAL_TRIALS trial_result · 2021-04-20Clinical Trial Update: Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of an EGFR-TKI combined with nimotuzumab for leptomeningeal metastases in lung can…
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CLINICAL_TRIALS trial_result · 2020-06-11Clinical Trial Update: Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer [Phase 2]
Phase 2 trial evaluating osimertinib with bevacizumab for leptomeningeal metastasis in EGFR-mutant non-small cell lung cancer is in progress…
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CLINICAL_TRIALS trial_result · 2020-05-27Clinical Trial Update: Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 4]
Clinical trial update evaluating recombinant human endostatin for leptomeningeal metastasis in non-small cell lung cancer (Phase 4) with eff…
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CLINICAL_TRIALS trial_result · 2020-05-27Clinical Trial Update: Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 4]
Phase 4 trial update evaluating the efficacy and safety of durvalumab in leptomeningeal metastasis.
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CLINICAL_TRIALS trial_result · 2019-12-26Clinical Trial Update: Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors [Phase 1, Phase 2]
Phase 1/2 trial evaluating concurrent intrathecal pemetrexed with involved-field radiotherapy for leptomeningeal metastasis from solid tumor…
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CLINICAL_TRIALS trial_result · 2019-11-04Clinical Trial Update: Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 2]
Phase 2 trial evaluating osimertinib with or without bevacizumab for EGFR-mutant non-small cell lung cancer with leptomeningeal metastasis.
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CLINICAL_TRIALS trial_result · 2019-08-01Clinical Trial Update: Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors [Phase 2]
Phase 2 trial evaluating concurrent involved-field radiotherapy with intrathecal chemotherapy for leptomeningeal metastases from solid tumor…
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CLINICAL_TRIALS trial_result · 2018-03-27Clinical Trial Update: Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System [Phase 1, Phase 2]
A phase 1/2 trial of intrathecal rituximab for lymphoid malignancies involving the central nervous system was terminated with results posted…
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CLINICAL_TRIALS research · 2017-10-26Clinical Trial Update: A Prospective, Observational Trial on the Diagnostic and Prognostic of LM
This entry describes a prospective observational trial evaluating diagnostic and prognostic aspects of leptomeningeal metastasis, in the con…
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CLINICAL_TRIALS research · 2017-01-24Clinical Trial Update: Detection of CSF Next Generation Sequencing in the Application of Brain Metastases From Lung Adenocarcinoma or Meningeal Metastasis
A clinical trial sponsored by Shandong Cancer Hospital and Institute is evaluating cerebrospinal fluid next-generation sequencing for detect…
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CLINICAL_TRIALS research · 2016-06-17Clinical Trial Update: A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
A multi-center prospective observational biomarker study in EGFR-mutant non-small cell lung cancer patients with leptomeningeal metastasis.
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CLINICAL_TRIALS trial_result · 2016-05-16Clinical Trial Update: RTA 744 Injection in Patients With Leptomeningeal Disease [Phase 1]
Phase 1 trial of RTA 744 injection for leptomeningeal disease in patients with neoplastic meningitis and other CNS/solid tumors has been ter…
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CLINICAL_TRIALS trial_result · 2014-02-24Clinical Trial Update: Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. [Phase 1]
This Phase 1 trial assesses the safety of giving whole-brain radiation therapy (WBR) at the same time as intrathecal liposomal cytarabine (D…
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CLINICAL_TRIALS research · 2013-10-29Clinical Trial Update: Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases [Phase 2]
Phase 2 clinical and pharmacological study of 2B3-101 in patients with breast cancer and leptomeningeal metastases; current status is unknow…
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CLINICAL_TRIALS trial_result · 2013-10-16Clinical Trial Update: Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis [Phase 2]
A Phase 2 trial evaluating bevacizumab with etoposide and cisplatin in breast cancer patients with brain and/or leptomeningeal metastases ha…
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CLINICAL_TRIALS trial_result · 2013-02-20Clinical Trial Update: LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial of LMB-7 Immunotoxin for leptomeningeal metastasis has completed.