Leptomeningeal Carcinomatosis
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CLINICAL_TRIALS trial_result · 2025-11-25Clinical Trial Update: Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis [Phase 4]
A Phase 4 trial evaluating intrathecal chemotherapy delivered via an Ommaya reservoir for HER2-negative breast cancer with leptomeningeal me…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Firmonertinib in the Treatment of EGFR(+) NSCLC Patients With Central Nervous System Metastasis
The clinical trial evaluating Firmonertinib for EGFR-positive non-small cell lung cancer patients with central nervous system metastasis has…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis [Phase 1]
A phase 1 safety study of RTA 744 in patients with leptomeningeal carcinomatosis (neoplastic meningitis) was terminated.
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CLINICAL_TRIALS trial_result · 2023-04-24Clinical Trial Update: ANG1005 in Leptomeningeal Disease From Breast Cancer [Phase 3]
Phase 3 clinical trial update for ANG1005 in leptomeningeal disease from breast cancer (leptomeningeal carcinomatosis/metastases).
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD [Phase 2]
A Phase 2 trial of tucatinib, trastuzumab, and capecitabine for HER2-positive leptomeningeal disease in metastatic breast cancer was termina…
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CLINICAL_TRIALS trial_result · 2022-11-14Clinical Trial Update: Ipilimumab and Nivolumab in Leptomeningeal Metastases [Phase 2]
A Phase 2 trial evaluating the combination of ipilimumab and nivolumab for leptomeningeal carcinomatosis has completed and posted results.
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CLINICAL_TRIALS trial_result · 2017-07-07Clinical Trial Update: Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer [Phase 2]
Phase II trial evaluating liposomal cytarabine with high-dose methotrexate for central nervous system metastases from breast cancer; the stu…
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CLINICAL_TRIALS trial_result · 2013-07-03Clinical Trial Update: Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer [Phase 1]
A Phase 1 clinical trial evaluating a monoclonal antibody therapy for leptomeningeal cancer has completed, providing early safety and tolera…
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CLINICAL_TRIALS trial_result · 2013-02-20Clinical Trial Update: Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors [Phase 1]
A Phase 1 study evaluating intrathecal busulfan for leptomeningeal tumors has completed, assessing safety and dosing in patients with recurr…
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CLINICAL_TRIALS trial_result · 2012-11-09Clinical Trial Update: Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain [Phase 1]
This entry describes a Phase 1 clinical trial of topotecan in patients with recurrent, progressive, or refractory cancer that has metastasiz…
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CLINICAL_TRIALS trial_result · 2011-07-26Clinical Trial Update: A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer [Phase 2]
A Phase 2 trial evaluating erlotinib for leptomeningeal carcinomatosis in EGFR-mutant non-small cell lung cancer was terminated.