Leptomeningeal Carcinomatosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV) [Phase 1]
First-in-human, dose-escalation Phase 1 study of a dendritic cell vaccine (DCV) is underway, with recruitment for leptomeningeal carcinomato…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases [NA]
A clinical trial evaluating CSF and blood plasma liquid biopsy in patients with metastatic solid tumors, with and without brain metastases o…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology
This clinical trial update notes ongoing recruitment for a study at MD Anderson evaluating patient perceptions of quality of care delivered …
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluating hippocampal avoidance in craniospinal irradiation for leptomeningeal metastases from breast cancer or no…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer [Phase 2]
A Phase 2 clinical trial evaluating photon craniospinal irradiation for leptomeningeal metastases arising from breast cancer or non-small ce…
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CLINICAL_TRIALS trial_result · 2025-11-25Clinical Trial Update: Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis [Phase 4]
A Phase 4 trial evaluating intrathecal chemotherapy delivered via an Ommaya reservoir for HER2-negative breast cancer with leptomeningeal me…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Firmonertinib in the Treatment of EGFR(+) NSCLC Patients With Central Nervous System Metastasis
The clinical trial evaluating Firmonertinib for EGFR-positive non-small cell lung cancer patients with central nervous system metastasis has…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis [Phase 1]
A phase 1 safety study of RTA 744 in patients with leptomeningeal carcinomatosis (neoplastic meningitis) was terminated.
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CLINICAL_TRIALS research · 2024-09-20Clinical Trial Update: Intrathecal Pemetrexed Combined With High-dose Furmonertinib and Beva for EGFR-m NSCLC With Leptomeningeal Metastases [Phase 2]
A Phase 2 trial update describing a novel combination of intrathecal pemetrexed with high-dose furmonertinib and bevacizumab for EGFR-mutant…
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CLINICAL_TRIALS trial_result · 2023-04-24Clinical Trial Update: ANG1005 in Leptomeningeal Disease From Breast Cancer [Phase 3]
Phase 3 clinical trial update for ANG1005 in leptomeningeal disease from breast cancer (leptomeningeal carcinomatosis/metastases).
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CLINICAL_TRIALS trial_result · 2023-02-08Clinical Trial Update: Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD [Phase 2]
A Phase 2 trial of tucatinib, trastuzumab, and capecitabine for HER2-positive leptomeningeal disease in metastatic breast cancer was termina…
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CLINICAL_TRIALS trial_result · 2022-11-14Clinical Trial Update: Ipilimumab and Nivolumab in Leptomeningeal Metastases [Phase 2]
A Phase 2 trial evaluating the combination of ipilimumab and nivolumab for leptomeningeal carcinomatosis has completed and posted results.
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CLINICAL_TRIALS trial_result · 2017-07-07Clinical Trial Update: Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer [Phase 2]
Phase II trial evaluating liposomal cytarabine with high-dose methotrexate for central nervous system metastases from breast cancer; the stu…
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CLINICAL_TRIALS other · 2016-06-07Clinical Trial Update: Expanded Access to ANG1005 for Individual Patients
Expanded access program for ANG1005 (Angiochem) for individual patients with several brain cancers; the program is no longer available.
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CLINICAL_TRIALS trial_result · 2013-07-03Clinical Trial Update: Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer [Phase 1]
A Phase 1 clinical trial evaluating a monoclonal antibody therapy for leptomeningeal cancer has completed, providing early safety and tolera…
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CLINICAL_TRIALS trial_result · 2013-02-20Clinical Trial Update: Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors [Phase 1]
A Phase 1 study evaluating intrathecal busulfan for leptomeningeal tumors has completed, assessing safety and dosing in patients with recurr…
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CLINICAL_TRIALS trial_result · 2012-11-09Clinical Trial Update: Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain [Phase 1]
This entry describes a Phase 1 clinical trial of topotecan in patients with recurrent, progressive, or refractory cancer that has metastasiz…
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CLINICAL_TRIALS trial_result · 2011-07-26Clinical Trial Update: A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer [Phase 2]
A Phase 2 trial evaluating erlotinib for leptomeningeal carcinomatosis in EGFR-mutant non-small cell lung cancer was terminated.