Lennox-gastaut Syndrome
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Sign up freeTop drugs studied for this disease
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EMA approval · 2026-08-20EMA Authorised: Epidyolex (cannabidiol) — Jazz Pharmaceuticals Ireland Limited
Authorised cannabidiol medicine Epidyolex for Lennox-Gastaut syndrome and other epilepsies with myoclonic features.
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Results: A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome [Phase 3]
Phase 3 trial evaluating soticlestat as add-on therapy in children and adults with Dravet syndrome or Lennox-Gastaut syndrome has terminated…
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EMA approval · 2026-04-24EMA Authorised: Epidyolex (cannabidiol) — Jazz Pharmaceuticals Ireland Limited
Epidyolex (cannabidiol) has been authorised by the EMA for Lennox-Gastaut syndrome and myoclonic epilepsies, with Jazz Pharmaceuticals Irela…
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CLINICAL_TRIALS safety_alert · 2026-04-22Clinical Trial Update: Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution [Phase 4]
This Phase 4 clinical trial update describes ongoing assessment of the potential for chronic liver injury in participants treated with Epidi…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome [Phase 3]
A Phase 3 trial evaluating Clemizole HCl for Lennox-Gastaut syndrome is currently recruiting. The sponsor is Epygenix.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Pallidothalamic Tracts Electrical Stimulation for Lennox-Gastaut Syndrome [NA]
A clinical trial investigates pallidothalamic tract electrical stimulation as a treatment for Lennox-Gastaut syndrome; the study is currentl…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial [NA]
A pediatric deep brain stimulation trial for epilepsy in Lennox-Gastaut syndrome is recruiting at University College London.
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: A Study of Soticlestat in Adults and Children With Rare Epilepsies [Phase 2]
Takeda reports termination of a Phase 2 study of Soticlestat in adults and children with rare epilepsies, with results posted.
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex [Phase 4]
A Phase 4 study is evaluating how children with Dravet syndrome or Lennox-Gastaut syndrome transition from artisanal cannabidiol to Epidiole…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY
An observational study of Epidyolex (cannabidiol) in Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex is currently r…
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: RNS System LGS Feasibility Study [Phase 2]
The RNS System LGS feasibility study (Phase 2) is currently active but not recruiting, evaluating responsive neurostimulation for Lennox-Gas…
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CLINICAL_TRIALS trial_result · 2025-12-03Clinical Trial Update: Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy [Phase 2]
This report covers a long-term, open-label Phase 2 safety study of LP352 in developmental and epileptic encephalopathy, including Dravet and…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome [Phase 3]
Phase 3 study update reporting long-term safety data for ZX008 (fenfluramine hydrochloride) oral solution in children and adults with epilep…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGS [NA]
This clinical trial update describes a study on reduced EEG home monitoring during fenfluramine titration for Dravet syndrome and Lennox-Gas…
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures [Phase 3]
A Phase 3 study of adjunctive cannabidiol oral solution GWP42003-P in children with tuberous sclerosis complex, Dravet syndrome, or Lennox-G…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome [Phase 3]
A Phase 3 study of Soticlestat as add-on therapy for children and adults with Dravet syndrome or Lennox-Gastaut syndrome has been terminated…
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CLINICAL_TRIALS withdrawal · 2025-09-15Clinical Trial Update: An Extended Access Program (EAP) for Perampanel
The extended access program for perampanel has ended and is no longer available.
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CLINICAL_TRIALS trial_result · 2025-08-28Clinical Trial Update: Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot [NA]
The CADET pilot trial evaluating adaptive deep brain stimulation for pediatric epilepsy has completed, with no outcome data provided in the …
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: BMB-101 in Absence Epilepsy and DEE [Phase 2]
Phase 2 clinical trial update for BMB-101 in absence epilepsy and developmental and epileptic encephalopathies, including Jeavons syndrome, …
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults [Phase 3]
Phase 3 clinical trial evaluating carisbamate as adjunctive treatment for seizures in Lennox-Gastaut syndrome; recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303
This update announces an Extended Access Program for participants who completed the Rufinamide study E2080-G000-303, providing continued acc…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut Syndrome [Phase 3]
Phase 3 study evaluating ZX008 (fenfluramine hydrochloride) as adjunctive therapy for Lennox-Gastaut syndrome has completed and its results …
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in Spain
This completed Spanish registry study collected information on how often Dravet syndrome and Lennox-Gastaut syndrome occur and new cases acr…
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EMA approval · 2025-04-15EMA Authorised: Inovelon (rufinamide) — Eisai GmbH
EMA authorised Inovelon (rufinamide) by Eisai GmbH for epilepsy, following a decision on 28 November 2023.
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FDA approval · 2025-04-15FDA Approved: RUFINAMIDE — Original Application (Novadoz Pharmaceuticals LLC)
FDA approved Rufinamide from Novadoz Pharmaceuticals LLC through an Original Abbreviated New Drug Application.