Leber Hereditary Optic Neuropathy
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year [Phase 3]
A Phase 3 trial evaluating bilateral intravitreal GS010 for Leber hereditary optic neuropathy due to the ND4 mutation has completed and post…
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients [Phase 1, Phase 2]
A safety evaluation update from a Phase 1/2 gene therapy trial in Leber hereditary optic neuropathy, reporting safety outcomes without effic…
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: REALITY LHON Registry
The REALITY LHON Registry clinical trial, conducted by GenSight Biologics for Leber Hereditary Optic Neuropathy, has completed.
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations [Phase 1, Phase 2]
A Phase 1/2 gene therapy trial for Leber hereditary optic neuropathy caused by ND1 mutations has been terminated.
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CLINICAL_TRIALS trial_result · 2024-08-07Clinical Trial Update: Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy [Phase 1]
Phase 1 safety study of an adeno-associated virus vector gene therapy for Leber hereditary optic neuropathy has completed enrollment. Result…
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CLINICAL_TRIALS trial_result · 2024-01-25Clinical Trial Update: RESCUE and REVERSE Long-term Follow-up [Phase 3]
Long-term follow-up results from GenSight Biologics' Phase 3 RESCUE and REVERSE trials in Leber hereditary optic neuropathy have been posted…
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CLINICAL_TRIALS trial_result · 2023-09-22Clinical Trial Update: Trial of Befizal® 200 mg for the Treatment of Leber Hereditary Optic Neuropathy [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating Befizal 200 mg for Leber hereditary optic neuropathy has completed.
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CLINICAL_TRIALS trial_result · 2023-04-21Clinical Trial Update: Study to Assess the Efficacy and Safety of Raxone in LHON Patients [Phase 4]
Phase 4 trial update for Raxone in Leber's Hereditary Optic Neuropathy (LHON) has completed with results posted in 2023.
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CLINICAL_TRIALS trial_result · 2022-11-14Clinical Trial Update: Gene Therapy Clinical Trial for the Treatment Of Leber's HereDitary Optic Neuropathy [Phase 2, Phase 3]
Clinical trial update for a gene therapy targeting Leber's Hereditary Optic Neuropathy (LHON) at Phase 2/Phase 3; currently recruiting.
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CLINICAL_TRIALS trial_result · 2021-10-12Clinical Trial Update: A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy [Phase 2]
Phase 2 clinical trial evaluating safety, tolerability, and efficacy of elamipretide topical ophthalmic solution for Leber's Hereditary Opti…
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CLINICAL_TRIALS trial_result · 2020-09-17Clinical Trial Update: A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy [Phase 2, Phase 3]
A clinical trial update for rAAV2-ND4 delivered via a single intravitreal injection in Leber hereditary optic neuropathy, currently in Phase…
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CLINICAL_TRIALS trial_result · 2020-01-30Clinical Trial Update: Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)
A completed clinical trial study surveying historical visual acuity data in patients with Leber's Hereditary Optic Neuropathy (LHON); result…
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CLINICAL_TRIALS trial_result · 2020-01-28Clinical Trial Update: Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation [Phase 3]
GenSight Biologics completed a Phase 3 efficacy study of GS010 for vision loss due to Leber hereditary optic neuropathy (ND4 mutation). Resu…
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CLINICAL_TRIALS trial_result · 2020-01-23Clinical Trial Update: Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE) [Phase 3]
This entry covers the Phase 3 REVERSE trial of GS010 for vision loss in Leber hereditary optic neuropathy due to the ND4 mutation. Results w…
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CLINICAL_TRIALS trial_result · 2016-05-02Clinical Trial Update: Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON) [NA]
Clinical trial update reporting safety and efficacy results for rAAV2-ND4 in Leber Hereditary Optic Neuropathy; study completed with results…
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CLINICAL_TRIALS trial_result · 2014-09-29Clinical Trial Update: Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluated near-infrared LED therapy for Leber's Hereditary Optic Neuropathy; the study was terminated with result…
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CLINICAL_TRIALS trial_result · 2014-05-15Clinical Trial Update: Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey
This clinical trial update notes the completion of a historical case record survey for Leber Hereditary Optic Neuropathy (LHON) sponsored by…
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CLINICAL_TRIALS trial_result · 2013-05-27Clinical Trial Update: Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy [Phase 2]
A Phase 2 clinical trial evaluating idebenone for efficacy, safety, and tolerability in Leber's Hereditary Optic Neuropathy has completed.
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CLINICAL_TRIALS trial_result · 2013-05-27Clinical Trial Update: RHODOS Follow-up Single-visit Study
The RHODOS follow-up single-visit trial in Leber's hereditary optic neuropathy has completed, according to an update from Santhera.
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CLINICAL_TRIALS trial_result · 2012-12-24Clinical Trial Update: A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) [Phase 3]
Phase 3 randomized, double-blind, placebo-controlled trial of curcumin for Leber hereditary optic neuropathy has been completed.