Iron Overload
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2015-09-29Clinical Trial Update: Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia [Phase 1]
A Phase 1 safety and pharmacokinetic study of escalating doses of SP-420, an iron chelator, in patients with beta-thalassemia was terminated…
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FDA approval · 2015-09-09FDA Approved: FERRIPROX — Original Application (Chiesi USA, Inc.)
The FDA granted approval for Ferriprox (deferiprone) to treat iron overload under an original NDA filed by Chiesi USA, Inc.
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CLINICAL_TRIALS trial_result · 2015-09-09Clinical Trial Update: Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major [Phase 3]
Phase 3 trial evaluating amlodipine for prevention and treatment of iron overload in patients with thalassemia major; the study has complete…
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CLINICAL_TRIALS trial_result · 2015-09-01Clinical Trial Update: Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox
A completed clinical trial evaluating renal function in thalassemia patients with iron overload treated with the oral chelator deferasirox.
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CLINICAL_TRIALS trial_result · 2015-08-17Clinical Trial Update: Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy [Phase 2]
Phase 2 pharmacokinetics study of SSP-004184 for iron overload due to chronic transfusion-dependent conditions was terminated with results p…
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CLINICAL_TRIALS trial_result · 2015-04-21Clinical Trial Update: Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis [Phase 3]
Phase 3 trial evaluating phlebotomy to reduce hepatocellular carcinoma risk in patients with compensated alcoholic cirrhosis and iron overlo…
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FDA approval · 2015-03-30FDA Approved: JADENU — Original Application (Novartis Pharmaceuticals Corporation)
FDA approved JADENU (deferasirox) through an Original Application for the treatment of chronic iron overload due to blood transfusions; the …
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CLINICAL_TRIALS trial_result · 2015-03-10Clinical Trial Update: Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization.
A Rennes University Hospital-sponsored trial investigating rare iron overload disorders excluding C282Y homozygosity has been terminated; th…
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CLINICAL_TRIALS research · 2014-11-13Clinical Trial Update: Iron Homoeostasis in Inflammation
Clinical trial on iron homeostasis in inflammatory and infectious conditions has completed, encompassing iron-deficiency anemia and iron ove…
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CLINICAL_TRIALS trial_result · 2014-10-28Clinical Trial Update: Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia [Phase 4]
Phase 4 study assessing the safety and efficacy of Desferasirox in Chinese patients with iron overload and aplastic anemia.
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CLINICAL_TRIALS trial_result · 2014-07-17Clinical Trial Update: MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias
This update reports the completion of a clinical trial evaluating MR imaging to detect diffuse myocardial fibrosis in transfusion-dependent …
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CLINICAL_TRIALS research · 2014-02-19Clinical Trial Update: MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload)
Update on the MEPHISTO trial (NCT02066012) assessing macrophage phenotype in metabolic syndrome with iron overload, sponsored by University …
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CLINICAL_TRIALS trial_result · 2013-11-26Clinical Trial Update: Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis [Phase 2]
Phase 2 trial evaluating subcutaneous desferrioxamine for transfusional iron overload has completed, including patients with beta-thalassemi…
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CLINICAL_TRIALS trial_result · 2013-06-11Clinical Trial Update: Retrospective Evaluation of Adult and Pediatric Transfusion-dependent Patients Treated With Deferasirox Therapy
This retrospective study evaluated outcomes in adult and pediatric transfusion-dependent patients treated with deferasirox for iron overload…
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FDA approval · 2012-11-15FDA Approved: FERRIPROX — Supplemental Application (Chiesi USA, Inc.)
The FDA approved a supplemental application for Ferriprox (deferiprone) filed by Chiesi USA, Inc., to modify/expand the product’s labeling.
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FDA label_change · 2012-07-18FDA Approved: DEFEROXAMINE — Supplemental Application (Fresenius Kabi USA, LLC)
FDA approved a supplemental application for Deferoxamine (Deferoxamine Mesylate) from Fresenius Kabi USA, LLC, likely involving changes to l…
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FDA approval · 2012-06-20FDA Approved: DEFEROXAMINE — Supplemental Application (Fresenius Kabi USA, LLC)
FDA approved a supplemental application for Deferoxamine Mesylate (Deferoxamine) from Fresenius Kabi USA, LLC.
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CLINICAL_TRIALS trial_result · 2012-05-21Clinical Trial Update: Cytochrome P450 2E1 and Iron Overload [Phase 2]
Phase 2 clinical trial evaluating the role of cytochrome P450 2E1 in iron overload and insulin resistance has been completed.
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CLINICAL_TRIALS trial_result · 2012-05-01Clinical Trial Update: Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload [Phase 4]
Open-label, single-arm Phase 4 pilot trial in adults who underwent allogeneic hematopoietic stem cell transplantation with transfusional iro…
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FDA approval · 2012-04-20FDA Approved: FERRIPROX — Supplemental Application (Chiesi USA, Inc.)
The FDA approved a supplemental application for Ferriprox (deferiprone) by Chiesi USA, Inc.
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CLINICAL_TRIALS approval · 2012-02-09Clinical Trial Update: Compassionate Use of Deferiprone for Patients With Thalassemia and Iron-Induced Heart Disease
Deferiprone has received approval for marketing to treat iron overload in patients with thalassemia and iron-induced heart disease.
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CLINICAL_TRIALS research · 2012-02-06Clinical Trial Update: Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload [Phase 2, Phase 3]
A Phase 2/3 clinical trial comparing the combination of deferasirox and deferiprone to the combination of deferiprone and deferoxamine (Desf…
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FDA approval · 2011-12-16FDA Approved: DESFERAL — Supplemental Application (MITEM PHARMA)
The FDA approved a supplemental application for DESFERAL (deferoxamine mesylate) submitted by Mitem Pharma.
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FDA approval · 2011-10-14FDA Approved: FERRIPROX — Original Application (Chiesi USA, Inc.)
Ferriprox (deferiprone) has been approved by the FDA under an original application from Chiesi USA, Inc. for the treatment of iron overload …
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CLINICAL_TRIALS research · 2011-09-15Clinical Trial Update: Pilot Study of Non-Invasive Assessment of Hepatic And Myocardial Iron Through T2* Magnet Resonance Imaging (MRI) In Patients With Iron Overload
A pilot study evaluated non-invasive hepatic and myocardial iron assessment using T2* MRI in patients with iron overload; the trial status i…