Iron Overload
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Sign up freeTop drugs studied for this disease
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FDA approval · 2019-07-24FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Exjade (deferasirox) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2019-05-29Clinical Trial Update: Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload [Phase 2]
Phase 2 trial of deferasirox for iron overload in patients who underwent allogeneic stem cell transplant was terminated; results posted in 2…
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CLINICAL_TRIALS research · 2019-05-21Clinical Trial Update: Massive Iron Deposit Assessment [NA]
A completed clinical trial update from St. Jude investigating iron overload and excessive body iron burden with results posted in 2019.
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FDA approval · 2019-02-08FDA Approved: DEFERIPRONE — Original Application (Sun Pharmaceutical Industries, Inc.)
Sun Pharmaceutical Industries received FDA approval for Deferiprone via original ANDA for the iron chelator used to treat iron overload in t…
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FDA label_change · 2018-05-11FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for Exjade (deferasirox) submitted by Novartis to modify the labeling for the iron chelation therapy…
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FDA approval · 2018-05-11FDA Approved: JADENU — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for JADENU (deferasirox) by Novartis Pharmaceuticals Corporation to expand its labeling for iron che…
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FDA approval · 2018-04-20FDA Approved: FERRIPROX — Supplemental Application (Chiesi USA, Inc.)
The FDA approved a supplemental application for Ferriprox (deferiprone) filed by Chiesi USA, Inc., resulting in updated labeling for iron ch…
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CLINICAL_TRIALS trial_result · 2018-04-11Clinical Trial Update: Iron Overload in Pediatric Oncology Patients
This clinical trial update notes the completion of a study examining iron overload in pediatric oncology patients.
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FDA approval · 2018-02-16FDA Approved: EXJADE — Supplemental Application (Novartis Pharmaceuticals Corporation)
The FDA approved a supplemental application for Exjade (deferasirox) from Novartis Pharmaceuticals Corporation. The approval updates the lab…
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FDA approval · 2017-09-29FDA Approved: DEFEROXAMINE MESYLATE — Original Application (Apotex Corp.)
FDA approved Apotex Corp's generic deferoxamine mesylate (Deferoxamine Mesylate) under an original ANDA for the treatment of iron overload d…
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CLINICAL_TRIALS withdrawal · 2017-07-26Clinical Trial Update: Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group
A clinical trial comparing continuous glucose monitoring (CGM) and oral glucose tolerance testing (OGTT) in relation to pancreas T2* MRI-det…
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CLINICAL_TRIALS trial_result · 2017-07-24Clinical Trial Update: Non-invasive Quantification of Liver Iron With MRI [NA]
A completed clinical trial evaluating non-invasive quantification of liver iron using MRI, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Oral Nifedipine to Treat Iron Overload [Phase 1]
A Phase 1 trial evaluating oral nifedipine for treating iron overload in thalassemia has completed.
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Effects of Taking Prenatal Vitamin-mineral Supplements During Lactation on Iron Status and Markers of Oxidation [NA]
This completed clinical trial evaluated whether taking prenatal vitamin-mineral supplements during lactation affects iron status and markers…
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FDA approval · 2017-05-18FDA Approved: JADENU — Original Application (Novartis Pharmaceuticals Corporation)
The FDA approved Jadenu (deferasirox) from Novartis as an oral iron chelator for chronic iron overload due to blood transfusions. This is th…
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CLINICAL_TRIALS trial_result · 2017-01-31Clinical Trial Update: Safety and Efficacy of Iron Reduction by Phlebotomy [Phase 2]
Phase 2 clinical trial evaluating the safety and efficacy of reducing iron levels by phlebotomy in patients with iron overload; study comple…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Pharmacokinetic Study of Deferiprone in Paediatric Patients [Phase 2]
Phase 2 pharmacokinetic study of deferiprone in paediatric patients with chronic iron overload has been completed, with results posted.
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CLINICAL_TRIALS trial_result · 2016-11-17Clinical Trial Update: Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload [Phase 4]
Phase 4 study evaluating the efficacy and safety of oral deferasirox in iron overload patients 3-6 months after allogeneic hematopoietic cel…
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FDA approval · 2016-11-08FDA Approved: DEFEROXAMINE MESYLATE — Supplemental Application (Hospira, Inc.)
FDA approved a supplemental application for deferoxamine mesylate by Hospira, Inc., supporting the availability of a generic product.
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CLINICAL_TRIALS trial_result · 2016-10-26Clinical Trial Update: Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients [NA]
This document reports a clinical trial evaluating amlodipine as an adjuvant to iron chelation to prevent cardiac iron overload in beta-thala…
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CLINICAL_TRIALS research · 2016-07-14Clinical Trial Update: Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload
This clinical trial update outlines the use of MRI monitoring in patients with aplastic anemia and low- to intermediate-1-risk myelodysplast…
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CLINICAL_TRIALS trial_result · 2016-06-15Clinical Trial Update: Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients [NA]
This completed clinical trial evaluated whether phlebotomy improves insulin sensitivity in patients with insulin resistance and iron overloa…
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FDA approval · 2016-04-27FDA Approved: DESFERAL — Supplemental Application (MITEM PHARMA)
FDA approved a supplemental application for DESFERAL (deferoxamine mesylate) submitted by MITEM PHARMA.
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Hemochromatosis and Iron Overload Screening Study (HEIRS)
The Hemochromatosis and Iron Overload Screening Study (HEIRS), sponsored by NHLBI, has completed. The study examined screening for hemochrom…
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FDA approval · 2015-11-06FDA Approved: JADENU — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for JADENU (deferasirox) from Novartis Pharmaceuticals Corporation.