Intrahepatic Cholangiocarcinoma

• CLINICAL_TRIALS trial_result · 2025-08-12
  Clinical Trial Update: Cryoablation Combined With Lenvatinib Plus QL1706 (Iparomlimab/Tuvonralimab) in Patients With Advanced Intrahepatic Cholangiocarcinoma [Phase 2]

  This document provides an update on a Phase 2 clinical trial evaluating cryoablation in combination with lenvatinib and QL1706 for advanced …

• CLINICAL_TRIALS trial_result · 2025-08-08
  Clinical Trial Update: Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma

  This clinical trial update notes that the study evaluating preoperative lymph node evaluation in cholangiocarcinoma has completed.

• CLINICAL_TRIALS research · 2025-08-06
  Clinical Trial Update: Selective Internal Radiation Therapy and Capecitabine (Chemotherapy) Treatment for Liver Cancer [Phase 2]

  Phase 2 clinical trial assessing selective internal radiation therapy with capecitabine for resectable intrahepatic cholangiocarcinoma, curr…

• CLINICAL_TRIALS research · 2025-08-03
  Clinical Trial Update: An Exploratory Study on Developing an Integrated Approach Combining Multimodal Imaging and Multi-omics Characterization of Tumor Heterogeneity for Precision Diagnosis and Treatment Optimization in Liver Cancer.

  This clinical trial update describes an exploratory study at Peking Union Medical College Hospital. It aims to integrate multimodal imaging …

• CLINICAL_TRIALS research · 2025-07-20
  Clinical Trial Update: Streamlining Radioembolization for Intrahepatic Cholangiocarcinoma

  Clinical trial NCT07043348 investigating streamlined radioembolization for intrahepatic cholangiocarcinoma has been terminated.

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• CLINICAL_TRIALS research · 2025-07-14
  Clinical Trial Update: A Prospective Phase II Study of Postoperative Concurrent Chemoradiotherapy in Patients With Intrahepatic Cholangiocarcinoma [Phase 2]

  A prospective Phase II study assessing postoperative concurrent chemoradiotherapy for intrahepatic cholangiocarcinoma, currently recruiting.

• CLINICAL_TRIALS research · 2025-07-10
  Clinical Trial Update: The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer [Phase 2]

  A Phase 2 trial is evaluating whether adding Yttrium-90 radiotherapy to gemcitabine, cisplatin, and durvalumab improves tumor shrinkage and …

• CLINICAL_TRIALS trial_result · 2025-07-10
  Clinical Trial Update: Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer

  This clinical trial update reports the termination of a feasibility study evaluating multi-platform profiling of resected biliary tract canc…

• CLINICAL_TRIALS trial_result · 2025-07-01
  Clinical Trial Update: A Study to Evaluate MIV-818 in Patients With Liver Cancer Manifestations [Phase 1, Phase 2]

  A completed Phase 1/2 clinical trial evaluating MIV-818 in liver cancer manifestations (hepatocellular carcinoma and intrahepatic cholangioc…

• CLINICAL_TRIALS withdrawal · 2025-06-29
  Clinical Trial Update: The Safety and Efficacy of CD-801 in Patients With Advanced Intrahepatic Cholangiocarcinoma [EARLY_Phase 1]

  An early-phase 1 trial of CD-801 for advanced intrahepatic cholangiocarcinoma has been withdrawn.

• CLINICAL_TRIALS research · 2025-06-26
  Clinical Trial Update: D-TACE-HAIC Combined With Envafolimab and Lenvatinib for Unresectable ICC

  A recruiting clinical trial is evaluating D-TACE-HAIC in combination with Envafolimab and Lenvatinib for unresectable intrahepatic cholangio…

• CLINICAL_TRIALS trial_result · 2025-05-23
  Clinical Trial Update: Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer [Phase 2]

  Phase 2 trial evaluating atezolizumab plus varlilumab with or without cobimetinib in advanced biliary tract cancers, with results posted in …

• CLINICAL_TRIALS research · 2025-05-15
  Clinical Trial Update: Neoantigen Vaccine Plus Capecitabine as Adjuvant Therapy for Intrahepatic Cholangiocarcinoma After Radical Resection [EARLY_Phase 1]

  An early-phase, adjuvant trial testing a neoantigen vaccine plus capecitabine after surgical resection for intrahepatic cholangiocarcinoma.

• CLINICAL_TRIALS trial_result · 2025-05-09
  Clinical Trial Update: SIRT Followed by CIS-GEM Chemotherapy Versus CIS-GEM Chemotherapy Alone as 1st Line Treatment of Patients With Unresectable Intrahepatic Cholangiocarcinoma [Phase 2, Phase 3]

  A randomized Phase 2/3 trial comparing selective internal radiation therapy (SIRT) followed by cisplatin-gemcitabine versus cisplatin-gemcit…

• CLINICAL_TRIALS trial_result · 2025-05-07
  Clinical Trial Update: A Study to Evaluate KIN-3248 in Participants With Advanced Tumors Harboring FGFR2 and//or FGFR3 Gene Alterations [Phase 1]

  Phase 1 study of KIN-3248 in FGFR2/3-altered advanced tumors was terminated. The trial enrolled patients with intrahepatic cholangiocarcinom…

• CLINICAL_TRIALS research · 2025-05-04
  Clinical Trial Update: Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluating a personalized tumor neoantigen mRNA therapy for advanced intrahepatic cholangiocarcinoma is currently…

• CLINICAL_TRIALS trial_result · 2025-05-01
  Clinical Trial Update: Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer [Phase 2]

  Phase 2 clinical trial evaluating durvalumab and tremelimumab with or without capecitabine as adjuvant therapy for biliary tract cancers; th…

• CLINICAL_TRIALS research · 2025-04-27
  Clinical Trial Update: Second-line Regimen Combined With Radiotherapy Versus Without Radiotherapy in Patients With Locally Advanced/Oligometastatic ICC After Failure of First-line Treatment：an Open-label, Randomized, Controlled Phase II Clinical Study [Phase 2]

  This clinical trial update outlines an open-label Phase II randomized study. It compares a second-line regimen combined with radiotherapy ve…

• CLINICAL_TRIALS research · 2025-04-24
  Clinical Trial Update: A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α srRNA in Treating Advanced ICC Patients [EARLY_Phase 1]

  A Phase 1 trial is evaluating intravenous HNF4α srRNA in patients with advanced intrahepatic cholangiocarcinoma. The study is currently recr…

• CLINICAL_TRIALS research · 2025-04-23
  Clinical Trial Update: Toripalimab Plus Lenvatinib and Gemcitabine-based Chemotherapy in 1L Treatment of Advanced ICC: a Phase III Study [Phase 3]

  This update describes a Phase III clinical trial evaluating toripalimab plus lenvatinib and gemcitabine-based chemotherapy as first-line tre…

• CLINICAL_TRIALS research · 2025-04-18
  Clinical Trial Update: mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma [Phase 2]

  Phase 2 trial evaluating a sequence of mFOLFIRINOX followed by hepatic arterial infusion of floxuridine with dexamethasone and systemic mFOL…

• CLINICAL_TRIALS trial_result · 2025-04-16
  Clinical Trial Update: PD-L1 Antibody Combined With CTLA-4 Antibody for Patients With Advanced Intrahepatic Cholangiocarcinoma Who Progressed After Standard Treatment [Phase 2]

  A Phase 2 clinical trial is evaluating the combination of a PD-L1 antibody with a CTLA-4 antibody in patients with advanced intrahepatic cho…

• CLINICAL_TRIALS trial_result · 2025-04-13
  Clinical Trial Update: Pemigatinib After Curative Local Therapy in Advanced iCCA With FGFR2 Fusion/Rearrangements [Phase 2]

  This Phase 2 trial of pemigatinib for advanced intrahepatic cholangiocarcinoma with FGFR2 fusions has been terminated. The study status indi…

• CLINICAL_TRIALS other · 2025-04-06
  Clinical Trial Update: Expanded Access Use of Derazantinib for Advanced Intrahepatic Cholangiocarcinoma (iCCA) With FGFR Genomic Alterations

  Expanded-access use of Derazantinib for advanced intrahepatic cholangiocarcinoma with FGFR alterations. The program, sponsored by Basilea Ph…

• CLINICAL_TRIALS research · 2025-04-06
  Clinical Trial Update: Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01) [Phase 2]

  CASTLE-ZS-01 is a Phase 2 trial evaluating cryoablation in combination with lenvatinib and tislelizumab versus FOLFOX in patients with advan…