Intrahepatic Cholangiocarcinoma

• CLINICAL_TRIALS trial_result · 2026-07-01
  Clinical Trial Results: Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC) [Phase 2]

  Phase 2 trial evaluating hepatic arterial infusion with floxuridine and dexamethasone plus systemic gemcitabine and oxaliplatin in unresecta…

• CLINICAL_TRIALS trial_result · 2026-06-25
  Clinical Trial Results: mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma [Phase 2]

  Phase 2 clinical trial investigating mFOLFIRINOX followed by hepatic arterial infusion of floxuridine and dexamethasone with systemic mFOLFI…

• CLINICAL_TRIALS trial_result · 2026-04-17
  Clinical Trial Update: A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors [Phase 1, Phase 2]

  Phase 1/2 study of CGT4859, an FGFR2/3 inhibitor, for intrahepatic cholangiocarcinoma, cholangiocarcinoma, and other advanced solid tumors; …

• CLINICAL_TRIALS trial_result · 2026-04-07
  Clinical Trial Update: DEB-TACE Combined With Apatinib and PD-1 for the Treatment of Intrahepatic Cholangiocarcinoma [Phase 2]

  Phase 2 study evaluating DEB-TACE combined with apatinib and a PD-1 antibody for intrahepatic cholangiocarcinoma has completed.

• CLINICAL_TRIALS trial_result · 2026-04-03
  Clinical Trial Update: An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

  ClinicalTrials.gov entry for an exosome-based liquid biopsy to differentiate hepatocellular carcinoma from intrahepatic cholangiocarcinoma, …

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• CLINICAL_TRIALS trial_result · 2026-03-18
  Clinical Trial Update: A Study on Intratumoral Fibrosis and α-SMA Expression in Intrahepatic Cholangiocarcinoma

  A completed clinical trial evaluating intratumoral fibrosis and alpha-SMA expression in intrahepatic cholangiocarcinoma.

• CLINICAL_TRIALS trial_result · 2026-03-13
  Clinical Trial Update: An Exosomal miRNA-based Liquid Biopsy for ICC Detection

  The clinical trial NCT07225452 investigating an exosomal miRNA-based liquid biopsy for detecting intrahepatic cholangiocarcinoma has complet…

• CLINICAL_TRIALS trial_result · 2026-03-13
  Clinical Trial Update: Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.

  This completed clinical trial evaluated using a liquid biopsy based on exosomal miRNA to stratify metastasis risk in intrahepatic cholangioc…

• CLINICAL_TRIALS trial_result · 2026-03-05
  Clinical Trial Update: Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma [Phase 1]

  Phase 1 clinical trial evaluating hypofractionated radiation therapy in combination with Bintrafusp alfa for locally advanced or metastatic …

• CLINICAL_TRIALS trial_result · 2026-02-27
  Clinical Trial Update: REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors [Phase 1, Phase 2]

  A first-in-human study of RLY-4008, a highly selective FGFR2 inhibitor, in intrahepatic cholangiocarcinoma and other advanced solid tumors h…

• CLINICAL_TRIALS trial_result · 2026-01-28
  Clinical Trial Update: Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA [Phase 2]

  This clinical trial update reports termination of a Phase 2 study evaluating perioperative hepatic arterial infusion chemotherapy with A+T (…

• CLINICAL_TRIALS trial_result · 2026-01-21
  Clinical Trial Update: Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer [Phase 2]

  Phase 2 trial comparing oral cryotherapy with acupressure/acupuncture versus oral cryotherapy alone to prevent oxaliplatin-induced periphera…

• CLINICAL_TRIALS trial_result · 2026-01-09
  Clinical Trial Update: Efficacy and Safety of TT-00420 (Tinengotinib) Tablets Versus Chemotherapy in Patients With Advanced Intrahepatic Cholangiocarcinoma Harboring FGFR2 Fusions/Rearrangements or Mutations [Phase 3]

  A Phase 3 trial evaluating Tinengotinib (TT-00420) versus chemotherapy in patients with advanced intrahepatic cholangiocarcinoma harboring F…

• CLINICAL_TRIALS trial_result · 2026-01-06
  Clinical Trial Update: HAIC Combined With Donafenib and Sintilimab for Unresectable ICC [Phase 2]

  Phase 2 trial evaluating hepatic arterial infusion chemotherapy combined with donafenib and sintilimab for unresectable intrahepatic cholang…

• CLINICAL_TRIALS trial_result · 2025-12-30
  Clinical Trial Update: HAIC Plus Systemic Chemotherapy, Lenvatinib and Toripalimab in Advanced ICC [Phase 2]

  A Phase 2 trial evaluating hepatic arterial infusion chemotherapy plus systemic chemotherapy with lenvatinib and toripalimab in advanced int…

• CLINICAL_TRIALS trial_result · 2025-12-22
  Clinical Trial Update: NXP800 for the Treatment of Patients With Advanced or Metastatic Cholangiocarcinoma [Phase 1]

  Phase 1 trial of NXP800 for advanced or metastatic cholangiocarcinoma has been terminated.

• CLINICAL_TRIALS trial_result · 2025-12-05
  Clinical Trial Update: Treatment of Atezolizumab and Derazantinib in Patients With Advanced iCCA With FGFR2 Fusions/Rearrangements [Phase 2]

  Phase 2 clinical trial update on combined atezolizumab and derazantinib for advanced intrahepatic cholangiocarcinoma with FGFR2 fusions.

• CLINICAL_TRIALS trial_result · 2025-10-29
  Clinical Trial Update: Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery [NA]

  This trial update reports that the sulfur colloid SPECT/CT liver-function study in patients with hepatocellular carcinoma or intrahepatic ch…

• CLINICAL_TRIALS trial_result · 2025-10-28
  Clinical Trial Update: Contrast-Enhanced Ultrasound for the Prediction of Bile Duct Cancer Response to Radioembolization Treatment [Phase 2]

  This Phase 2 trial evaluated Contrast-Enhanced Ultrasound as a predictor of response to radioembolization in intrahepatic cholangiocarcinoma…

• CLINICAL_TRIALS trial_result · 2025-10-23
  Clinical Trial Update: Pressure Enabled Delivery of SD-101 With Checkpoint Blockade for Primary Liver Tumors [Phase 1, Phase 2]

  A Phase 1/2 trial evaluating pressure-enabled delivery of SD-101 in combination with checkpoint blockade for primary liver tumors has been t…

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Taxoprexin® Treatment for Advanced Primary Cancers of the Liver, Gallbladder or Biliary Tract [Phase 2]

  Phase 2 trial of Taxoprexin for advanced primary cancers of the liver, gallbladder, or biliary tract was terminated.

• CLINICAL_TRIALS trial_result · 2025-10-09
  Clinical Trial Update: Effects on Quality of Life With Zinc Supplementation in Patients With Gastrointestinal Cancer [NA]

  This trial update describes the effects of zinc supplementation on quality of life in patients with gastrointestinal cancers. The study has …

• CLINICAL_TRIALS trial_result · 2025-10-01
  Clinical Trial Update: Nal-IRI With 5-fluorouracil (5-FU) and Leucovorin or Gemcitabine Plus Cisplatin in Advanced Biliary-tract Cancer [Phase 2]

  This clinical trial update notes the completion of a phase 2 study evaluating nanoliposomal irinotecan (nal-IRI) with either 5-fluorouracil/…

• CLINICAL_TRIALS trial_result · 2025-09-08
  Clinical Trial Update: Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment [Phase 2]

  This Phase 2 trial evaluated colchicine for palliative treatment of primary hepatic malignant tumors in patients ineligible for curative tre…

• CLINICAL_TRIALS trial_result · 2025-08-15
  Clinical Trial Update: Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer [Phase 2]

  Phase 2 trial evaluating preoperative combination therapy with gemcitabine, cisplatin, and nab-paclitaxel for resectable cholangiocarcinoma,…