Intrahepatic Cholangiocarcinoma
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Streamlining Radioembolization for Intrahepatic Cholangiocarcinoma
Clinical trial NCT07043348 investigating streamlined radioembolization for intrahepatic cholangiocarcinoma has been terminated.
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CLINICAL_TRIALS research · 2025-07-14Clinical Trial Update: A Prospective Phase II Study of Postoperative Concurrent Chemoradiotherapy in Patients With Intrahepatic Cholangiocarcinoma [Phase 2]
A prospective Phase II study assessing postoperative concurrent chemoradiotherapy for intrahepatic cholangiocarcinoma, currently recruiting.
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: The Purpose of This Research Study is to See if Combining Gemcitabine, Cisplatin and Durvalumab Chemotherapy Treatments With a Direct Tumor Therapy Yittrium-90 (Y-90) Will Work Better Together to Shrink Tumors and Control Cancer [Phase 2]
A Phase 2 trial is evaluating whether adding Yttrium-90 radiotherapy to gemcitabine, cisplatin, and durvalumab improves tumor shrinkage and …
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: D-TACE-HAIC Combined With Envafolimab and Lenvatinib for Unresectable ICC
A recruiting clinical trial is evaluating D-TACE-HAIC in combination with Envafolimab and Lenvatinib for unresectable intrahepatic cholangio…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Neoantigen Vaccine Plus Capecitabine as Adjuvant Therapy for Intrahepatic Cholangiocarcinoma After Radical Resection [EARLY_Phase 1]
An early-phase, adjuvant trial testing a neoantigen vaccine plus capecitabine after surgical resection for intrahepatic cholangiocarcinoma.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Personalized Tumor Neoantigen mRNA Therapy for Advanced Intrahepatic Cholangiocarcinoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a personalized tumor neoantigen mRNA therapy for advanced intrahepatic cholangiocarcinoma is currently…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: Second-line Regimen Combined With Radiotherapy Versus Without Radiotherapy in Patients With Locally Advanced/Oligometastatic ICC After Failure of First-line Treatment：an Open-label, Randomized, Controlled Phase II Clinical Study [Phase 2]
This clinical trial update outlines an open-label Phase II randomized study. It compares a second-line regimen combined with radiotherapy ve…
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: A Clinical Trial Evaluating the Safety and Efficacy of Intravenous HNF4α srRNA in Treating Advanced ICC Patients [EARLY_Phase 1]
A Phase 1 trial is evaluating intravenous HNF4α srRNA in patients with advanced intrahepatic cholangiocarcinoma. The study is currently recr…
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CLINICAL_TRIALS research · 2025-04-23Clinical Trial Update: Toripalimab Plus Lenvatinib and Gemcitabine-based Chemotherapy in 1L Treatment of Advanced ICC: a Phase III Study [Phase 3]
This update describes a Phase III clinical trial evaluating toripalimab plus lenvatinib and gemcitabine-based chemotherapy as first-line tre…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma [Phase 2]
Phase 2 trial evaluating a sequence of mFOLFIRINOX followed by hepatic arterial infusion of floxuridine with dexamethasone and systemic mFOL…
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Cryoablation Combined With Lenvatinib Plus Tislelizumab Compared With FOLFOX in Patients With Advanced Intrahepatic Cholangiocarcinoma (CASTLE-ZS-01) [Phase 2]
CASTLE-ZS-01 is a Phase 2 trial evaluating cryoablation in combination with lenvatinib and tislelizumab versus FOLFOX in patients with advan…
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CLINICAL_TRIALS research · 2025-03-21Clinical Trial Update: Additional Chemotherapy Administered Directly Into the Liver Using a Chemo Pump in Patients With Bile Duct Cancer Inside the Liver Treatable by Surgery [Phase 2]
A Phase 2 clinical trial is exploring delivering chemotherapy directly into the liver with a pump for intrahepatic bile duct cancer (intrahe…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Neoadjuvant Therapy of HAIC（GEMOX） Combined With Adebrelimab and Lenvatinib for Resectable Intrahepatic Cholangiocarcinoma With High-risk Recurrence Factors [Phase 2]
Phase 2 trial evaluating neoadjuvant hepatic arterial infusion chemotherapy with GEMOX plus adebrelimab and lenvatinib for resectable intrah…
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Phase II Clinical Study of GemOX Hepatic Arterial Infusion Combined with Lenvatinib and Toripalimab for Advanced and Unresectable Intrahepatic Cholangiocarcinoma and Gallbladder Cancer [Phase 2]
Phase II study evaluating GemOX hepatic arterial infusion combined with lenvatinib and toripalimab for advanced unresectable intrahepatic ch…
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: TACE Combined With Tislelizumab in Patients With Advanced Intrahepatic Cholangiocarcinoma [Phase 2]
This Phase 2 trial update describes evaluating a combination of transarterial chemoembolization (TACE) and tislelizumab in patients with adv…
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: Cryoablation Combined with Anti-PD-1 Antibody in Patients with Advanced Intrahepatic Cholangiocarcinoma [Phase 2]
Phase 2 trial evaluating cryoablation in combination with an anti-PD-1 antibody for advanced intrahepatic cholangiocarcinoma is currently re…
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CLINICAL_TRIALS research · 2025-02-27Clinical Trial Update: Lenvatinib Plus Sintilimab in Patients With Immune Checkpoint Inhibitor Previously Treated Advanced Liver Cancer [Phase 2]
This clinical trial update reports a Phase 2 study evaluating the combination of lenvatinib and sintilimab for advanced liver cancer (intrah…
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CLINICAL_TRIALS research · 2025-02-11Clinical Trial Update: GOT Applied As Neoadjuvant Regimen for Patients of Resectable ICC with High-risk Factors of Recurrence [Phase 2]
Phase 2 clinical trial evaluating GOT as a neoadjuvant regimen for patients with resectable intrahepatic cholangiocarcinoma at high risk of …
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: Exploring the Efficacy and Safety of Tislelizumab in Combination With S-1 in the Treatment of Patients With Postoperative Recurrent High-risk Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2 clinical trial is evaluating the combination of tislelizumab and S-1 for patients with postoperative recurrent high-risk intrahepa…
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CLINICAL_TRIALS research · 2025-01-06Clinical Trial Update: Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG) [NA]
The LIVELONG trial from University of California, Davis is an ongoing study evaluating locally ablative therapy for oligoprogressive gastroi…
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CLINICAL_TRIALS research · 2025-01-03Clinical Trial Update: PD-1 Antibody (SHR-1210) Plus Capecitabine in Patients with Intrahepatic Cholangiocarcinoma After Surgery [Phase 2]
Phase 2 trial evaluating SHR-1210 (tislelizumab) plus capecitabine for postoperative intrahepatic cholangiocarcinoma is active but not recru…
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CLINICAL_TRIALS research · 2024-12-24Clinical Trial Update: Clinical Study of VG161 in Advanced Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2 clinical study of VG161 for advanced intrahepatic cholangiocarcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: HAIC Sequential TAE Combined With Tislelizumab and Surufatinib in Unresectable Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2 clinical trial update about using hepatic arterial infusion chemotherapy (HAIC) with subsequent transarterial embolization (TAE) i…
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CLINICAL_TRIALS research · 2024-11-05Clinical Trial Update: Combined HAIC, Lenvatinib and Pucotenlimab As Conversion Therapy for Unresectable Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2 clinical trial is evaluating a combination of hepatic arterial infusion chemotherapy (HAIC), lenvatinib, and pucotenlimab as conve…
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CLINICAL_TRIALS research · 2024-10-10Clinical Trial Update: Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma [NA]
A clinical trial is investigating liver transplantation for patients with stable, advanced intrahepatic cholangiocarcinoma. Enrollment is by…