Intrahepatic Cholangiocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver) [Phase 1, Phase 2]
Hoffmann-La Roche is conducting the MORPHEUS-Liver trial to evaluate the efficacy and safety of multiple immunotherapy-based treatment combi…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio [Phase 2]
Phase 2 clinical trial evaluating Yttrium-90 radioembolization combined with durvalumab, gemcitabine, and cisplatin for intrahepatic cholang…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery [Phase 2]
A Phase 2 clinical trial evaluating gemcitabine and oxaliplatin chemotherapy with optional floxuridine/dexamethasone pump in patients with u…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
Clinical trial registry entry for real-world evaluation of HistoSonics' Edison System for treating liver tumors; study is currently recruiti…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating autologous dendritic cell therapy and Prevnar vaccine with immune checkpoint inhibition following high-dose exter…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery [Phase 2]
Phase 2 trial evaluating durvalumab with gemcitabine and cisplatin for high-risk resectable intrahepatic cholangiocarcinoma before surgery i…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Single-Arm Study of Pembrolizumab With Gemcitabine and Cisplatin as Perioperative Therapy for Potentially Resectable Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2, single-arm clinical trial evaluating pembrolizumab with gemcitabine and cisplatin as perioperative therapy for potentially resect…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Scout Dose of Resin Microspheres [NA]
This trial update notes that a Scout dose study of resin microspheres is recruiting for liver-directed radioembolization in hepatocellular c…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Surveys, Blood Testing, and Fibroscan in Screening for Liver Fibrosis and Liver Cirrhosis [NA]
This update describes a study that uses surveys, blood testing, and FibroScan to screen for liver fibrosis and liver cirrhosis in patients w…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) [Phase 2]
Phase 2 clinical trial evaluating chemotherapy with or without binimetinib for advanced biliary tract cancers. The study is currently active…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Clinical Study to Evaluate the Efficacy and Safety of VG2025 in Intrahepatic Cholangiocarcinoma [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of VG2025 in intrahepatic cholangiocarcinoma is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement [Phase 2]
Phase II trial evaluating the combination of pemigatinib and durvalumab in previously treated advanced intrahepatic cholangiocarcinoma with …
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Liver Transplantation for Locally Advanced Intrahepatic Cholangiocarcinoma After SIRT and Chemotherapy [NA]
A clinical trial evaluating liver transplantation for locally advanced intrahepatic cholangiocarcinoma after selective internal radiation th…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Liver Transplantation in Intrahepatic Cholangiocarcinoma
A clinical trial investigating liver transplantation for intrahepatic cholangiocarcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial update shows ALE.P03 as monotherapy being studied in adults with selected advanced or metastatic CLDN1+ solid tum…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
A completed clinical trial (LyMIC) studying detection of lymph node metastasis in intrahepatic cholangiocarcinoma. The trial was sponsored b…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases [Phase 1]
Phase 1 trial evaluating pressurized intraperitoneal aerosolized nab-paclitaxel in combination with gemcitabine and cisplatin for biliary tr…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: HYPERION CCA: a Phase 2 Trial of Systemic Therapy With or Without Liver-directed Radiation Therapy for Patients With Advanced Intrahepatic Cholangiocarcinoma [Phase 2]
Phase 2 clinical trial (HYPERION CCA) evaluating systemic therapy with or without liver-directed radiation for advanced intrahepatic cholang…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Hepatic Arterial Infusion Chemotherapy (HAIC) Combined With Durvalumab and Lenvatinib in Patients With Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma: a Phase 2 Study(HAIC-quad Trial) [Phase 2]
A Phase 2 clinical trial (HAIC-quad) is evaluating hepatic arterial infusion chemotherapy combined with durvalumab and lenvatinib for locall…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Study of Liposomal Irinotecan Plus 5-FU/LV HAIC With Lenvatinib and a PD-1 Inhibitor in Advanced ICC [Phase 2]
Phase 2 trial evaluating liposomal irinotecan plus 5-FU/leucovorin hepatic arterial infusion with lenvatinib and a PD-1 inhibitor in advance…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating PDS01ADC with hepatic artery infusion pump and systemic therapy for metastatic colorectal cancer, intrah…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: REGULUS: MRI-guided Adaptive SABR for Liver Cancers [Phase 2]
Stanford's REGULUS trial investigates MRI-guided adaptive SABR for liver cancers, including hepatocellular carcinoma and intrahepatic cholan…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy [Phase 2]
This Phase 2 clinical trial evaluates the safety and feasibility of a hybrid tertiary- and community-delivery model for hepatic artery infus…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: HAI-Floxuridine, or SIRT, Combined With Gemox For Patients With Intra-Hepatic Cholangiocarcinoma Not Amenable to Resection (TOMCAT) [Phase 2]
Phase 2 TOMCAT trial evaluating hepatic arterial infusion floxuridine (HAI-Floxuridine) or SIRT, combined with gemcitabine and oxaliplatin (…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: HAIC Combined With Immune Therapy for Advanced, Non-Resectable ICC [Phase 2]
A Phase 2 clinical trial is evaluating hepatic arterial infusion chemotherapy combined with immune therapy for advanced, non-resectable intr…