Hypoxic-ischemic Encephalopathy
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CLINICAL_TRIALS research · 2017-03-14Clinical Trial Update: MRI of Neonate With HIE Before and During the Moderate Hypothermia
A clinical trial update describing MRI assessment of a neonate with hypoxic-ischemic encephalopathy before and during moderate therapeutic h…
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CLINICAL_TRIALS trial_result · 2017-02-02Clinical Trial Update: Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage [NA]
A clinical trial evaluating a rectum cooling system for hypoxic-ischemic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2017-01-26Clinical Trial Update: Autologous Cord Blood Cells for Brain Injury in Term Newborns [Phase 1]
Phase 1 study evaluating autologous cord blood cell therapy for brain injury in term newborns with hypoxic ischemic encephalopathy. The tria…
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia [EARLY_Phase 1]
An early phase 1 trial examining dexmedetomidine pharmacokinetics in neonates during therapeutic hypothermia for hypoxic-ischemic encephalop…
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CLINICAL_TRIALS trial_result · 2016-10-14Clinical Trial Update: Magnesium Sulphate in Perinatal Asphyxia [Phase 3]
This update reports the completion of a Phase 3 trial evaluating magnesium sulfate for perinatal asphyxia in moderate to severe hypoxic-isch…
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CLINICAL_TRIALS trial_result · 2016-09-26Clinical Trial Update: Home Stimulation for Brain-Asphyxiated Infants [Phase 2]
A Phase 2 trial evaluating home stimulation therapy for infants with hypoxic-ischemic brain injury has completed. The study was sponsored by…
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CLINICAL_TRIALS trial_result · 2016-09-05Clinical Trial Update: NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
The NeoAdapt 3 trial evaluating novel biomarkers for neonatal circulatory insufficiency in babies with hypoxic-ischemic encephalopathy has c…
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CLINICAL_TRIALS research · 2016-08-03Clinical Trial Update: Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy [NA]
A clinical trial investigating neural progenitor cells and paracrine factors as a therapy for Hypoxic-Ischemic Encephalopathy; trial status …
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CLINICAL_TRIALS trial_result · 2016-07-29Clinical Trial Update: Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest [Phase 3]
Phase 3 trial completed evaluating central nervous system sequelae after circulatory arrest in infants undergoing heart surgery.
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CLINICAL_TRIALS research · 2016-06-29Clinical Trial Update: Targeted Temperature Management After In-Hospital Cardiac Arrest [NA]
This clinical trial update concerns targeted temperature management after in-hospital cardiac arrest, focusing on hypoxic ischemic encephalo…
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CLINICAL_TRIALS trial_result · 2016-05-11Clinical Trial Update: TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia [NA]
This update confirms the completion of the TOBY trial evaluating whole-body therapeutic hypothermia for perinatal asphyxia and notes that re…
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CLINICAL_TRIALS trial_result · 2016-01-21Clinical Trial Update: The TOBY Children Study
The TOBY Children Study update reports the long-term follow-up results of therapeutic hypothermia in neonates with hypoxic-ischemic encephal…
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CLINICAL_TRIALS trial_result · 2015-07-16Clinical Trial Update: Hypothermia Enhanced by Magnesium Sulphate [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating hypothermia enhanced with magnesium sulfate for hypoxic-ischemic encephalopathy has completed.
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CLINICAL_TRIALS withdrawal · 2015-06-03Clinical Trial Update: MRI Thermal Imaging of Infants Undergoing Cooling for Hypoxic Ischemic Encephalopathy(HIE)
The clinical trial evaluating MRI thermal imaging during therapeutic cooling in infants with hypoxic ischemic encephalopathy has been withdr…
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CLINICAL_TRIALS trial_result · 2015-05-22Clinical Trial Update: Darbe Administration in Newborns Undergoing Cooling for Encephalopathy [Phase 1, Phase 2]
A Phase 1/2 trial evaluating darbepoetin alfa administration in newborns undergoing therapeutic cooling for hypoxic ischemic encephalopathy,…
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CLINICAL_TRIALS trial_result · 2014-12-08Clinical Trial Update: California Transport Cooling Trial [NA]
A Stanford-led clinical trial on cooling therapy for hypoxic ischemic encephalopathy completed and posted results.
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CLINICAL_TRIALS trial_result · 2014-07-31Clinical Trial Update: Neonatal Resuscitation in Zambia [Phase 3]
Phase 3 clinical trial in Zambia evaluating neonatal resuscitation has completed, with outcomes relevant to asphyxia neonatorum and hypoxic …
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CLINICAL_TRIALS trial_result · 2014-07-31Clinical Trial Update: Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy [Phase 1]
A Phase 1 pilot study of head cooling in preterm infants with hypoxic ischemic encephalopathy has completed with results posted.
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CLINICAL_TRIALS trial_result · 2013-12-13Clinical Trial Update: Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia [Phase 2]
Phase 2 study assessing safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with therapeutic hypother…
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CLINICAL_TRIALS research · 2013-10-14Clinical Trial Update: Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Hypoxic Ischemic Encephalopathy [Phase 1]
Phase 1 clinical trial evaluating umbilical cord-derived mesenchymal stem cells therapy for hypoxic ischemic encephalopathy; sponsor is Hebe…
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CLINICAL_TRIALS trial_result · 2013-09-13Clinical Trial Update: Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy [Phase 2]
A Phase 2 clinical trial evaluating Cerebrolysin for infants with a history of neonatal hypoxic-ischemic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2013-04-04Clinical Trial Update: Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy [Phase 3]
Phase 3 clinical trial evaluating the efficacy of therapeutic hypothermia plus magnesium sulfate for term and near-term infants with hypoxic…
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CLINICAL_TRIALS trial_result · 2012-11-09Clinical Trial Update: Neonatal Erythropoietin in Asphyxiated Term Newborns [Phase 1]
A Phase 1 trial evaluating neonatal erythropoietin for term newborns with Hypoxic-ischemic Encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2012-01-19Clinical Trial Update: Autologous Stem Cells in Newborns With Oxygen Deprivation [NA]
This clinical trial update describes the use of autologous stem cell therapy in newborns with oxygen deprivation, including conditions such …
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CLINICAL_TRIALS trial_result · 2011-01-26Clinical Trial Update: Intrathecal Stem Cells in Brain Injury [NA]
A completed clinical trial evaluating intrathecal stem cell therapy for brain injury associated with hypoxic-ischemic encephalopathy and cer…