Hypoxic-ischemic Encephalopathy
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CLINICAL_TRIALS trial_result · 2024-06-05Clinical Trial Update: PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns [Phase 3]
This update reports the completion of a Phase 3 trial evaluating erythropoietin for hypoxic-ischemic encephalopathy in newborns.
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CLINICAL_TRIALS research · 2024-05-24Clinical Trial Update: Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases [NA]
A clinical trial evaluating the efficacy of umbilical cord blood mononuclear cells (UCB-MNCs) for refractory neonatal diseases, including hy…
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CLINICAL_TRIALS withdrawal · 2024-05-10Clinical Trial Update: PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia [Phase 1]
The clinical trial evaluating caffeine pharmacokinetics and safety in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic h…
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CLINICAL_TRIALS research · 2024-05-01Clinical Trial Update: Is Feeding During Therapeutic Hypothermia Safe and Can Improve Outcomes in Infants With Hypoxic-ischaemic Encephalopathy [NA]
This clinical trial update indicates a study evaluating the safety and potential efficacy of feeding during therapeutic hypothermia in infan…
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CLINICAL_TRIALS trial_result · 2024-04-22Clinical Trial Update: Preemie Hypothermia for Neonatal Encephalopathy [NA]
Clinical trial update indicates the preemie hypothermia trial for neonatal encephalopathy has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2024-04-02Clinical Trial Update: Magnesium Sulfate in Neonatal HIE" [Phase 4]
Phase 4 trial update on magnesium sulfate use in neonates with hypoxic-ischemic encephalopathy (HIE).
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CLINICAL_TRIALS trial_result · 2023-07-11Clinical Trial Update: Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome [Phase 3]
Phase 3 trial evaluating allopurinol for neurocognitive outcomes after hypoxic-ischemic brain injury in newborns; status of the trial is cur…
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CLINICAL_TRIALS trial_result · 2023-05-03Clinical Trial Update: Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates [Phase 4]
A Phase 4 clinical trial assessing optimized hydrocortisone therapy during hypothermia in neonates with asphyxia and hypoxic-ischemic enceph…
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CLINICAL_TRIALS trial_result · 2023-04-21Clinical Trial Update: Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluated hydrocortisone for treating systemic hypotension during hypothermia in asphyxiated newborns with hypoxic-i…
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CLINICAL_TRIALS trial_result · 2022-01-26Clinical Trial Update: Holding, Stress, and Bonding During Therapeutic Hypothermia [NA]
This clinical trial update describes a study on holding, stress, and bonding during therapeutic hypothermia for Hypoxic-Ischemic Encephalopa…
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CLINICAL_TRIALS trial_result · 2021-01-12Clinical Trial Update: Beneficial Effect of Intravenous Magnesium Sulphate in Term Neonates With Hypoxic Ischemic Encephalopathy(HIE) [Phase 2]
Phase 2 trial reporting beneficial effect of intravenous magnesium sulfate in term neonates with hypoxic-ischemic encephalopathy (HIE).
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CLINICAL_TRIALS trial_result · 2020-07-13Clinical Trial Update: Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) [Phase 1, Phase 2]
Phase 1/2 trial NEATO evaluated neonatal erythropoietin with therapeutic hypothermia for brain injury due to hypoxic-ischemic events; study …
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CLINICAL_TRIALS research · 2018-07-06Clinical Trial Update: BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.
The BiHiVE2 study, investigating predictive biomarkers for Hypoxic-ischemic encephalopathy and asphyxia, has completed. The update documents…
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CLINICAL_TRIALS trial_result · 2018-06-21Clinical Trial Update: Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)
Completed clinical trial evaluating the clinical utility of serum biomarkers to guide management of neonatal Hypoxic Ischemic Encephalopathy…
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CLINICAL_TRIALS research · 2018-06-07Clinical Trial Update: Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia [Phase 1]
Phase 1 feasibility and safety study evaluating umbilical cord blood transfusion for treating neonatal cerebral ischemia and anemia.
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CLINICAL_TRIALS research · 2018-06-06Clinical Trial Update: Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy With Hypothermia Treatment
This clinical trial update discusses the long-term prognosis of neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypot…
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CLINICAL_TRIALS trial_result · 2018-05-02Clinical Trial Update: Correlation of Risk Factors and Severity of Hypoxic-ischaemic Encephalopathy
This completed clinical trial examined how various risk factors relate to the severity of Hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy [NA]
This entry provides an update on a clinical trial evaluating hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy, with the current…
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CLINICAL_TRIALS trial_result · 2018-04-03Clinical Trial Update: Reno-protective Effect of Brain Cooling in Newborn With Hypoxia
A completed clinical trial evaluating whether brain cooling offers reno-protection in newborns with hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS trial_result · 2018-01-05Clinical Trial Update: Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia [Phase 1, Phase 2]
A clinical trial evaluating the safety of clonidine in infants with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia has c…
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CLINICAL_TRIALS research · 2017-08-07Clinical Trial Update: Late Hypothermia for Hypoxic-Ischemic Encephalopathy [NA]
Clinical trial update on late hypothermia for hypoxic-ischemic encephalopathy in newborns with completed status and results posted.
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CLINICAL_TRIALS trial_result · 2017-07-06Clinical Trial Update: Protein Supplementation in Infants With Brain Injury [NA]
A completed clinical trial investigating protein supplementation in infants with brain injury, including perinatal stroke and hypoxic-ischem…
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CLINICAL_TRIALS research · 2017-06-09Clinical Trial Update: Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy [Phase 3]
This entry notes a Phase 3 clinical trial evaluating citicoline for treatment of newborns with hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS research · 2017-05-31Clinical Trial Update: Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy [Phase 3]
A status update on a Phase 3 clinical trial evaluating erythropoietin for neonatal hypoxic-ischemic encephalopathy.
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CLINICAL_TRIALS research · 2017-04-26Clinical Trial Update: Pharmacokinetics of Ampicillin in Neonates With Moderate to Severe Hypoxic-Ischemic Encephalopathy
A completed clinical trial update studying the pharmacokinetics of ampicillin in neonates with moderate to severe hypoxic-ischemic encephalo…