Hypoplastic Left Heart Syndrome
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
A France-based INSERM-sponsored clinical trial is recruiting to study how prenatal maternal mental health affects neurodevelopment in fetuse…
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: The CHILD Trial: Hypoplastic Left Heart Syndrome Study. [Phase 1]
Phase 1 clinical trial update for the CHILD Trial in hypoplastic left heart syndrome, with results posted.
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: 3D Modalities for Medical Student Education of Congenital Heart Disease [NA]
A completed trial assessing 3D modalities for medical student education on congenital heart disease, including Tetralogy of Fallot and Hypop…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Long-term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type
This trial update reports long-term outcomes for children with Hypoplastic left heart syndrome and examines the impact of Norwood shunt type…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) [Phase 3]
APOLLON is a Phase 3 trial evaluating infusion of cardiac stem/progenitor cells in patients with univentricular physiology, currently recrui…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical Patch [NA]
The Hospital for Sick Children is updating a study to evaluate a graphically designed, patient-specific surgical patch for reconstructing th…
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome [NA]
This clinical trial update describes fetal aortic valvuloplasty as a treatment approach for evolving Hypoplastic Left Heart Syndrome, with e…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome [Phase 2]
This Phase 2 trial evaluates intramyocardial injection of autologous umbilical cord blood-derived mononuclear cells during surgical repair o…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts [Phase 2]
This clinical trial update describes a Phase 2 study assessing safety and efficacy of a second-generation tissue engineered vascular graft f…
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CLINICAL_TRIALS trial_result · 2025-06-25Clinical Trial Update: Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. [Phase 2]
Phase IIb clinical trial evaluating Lomecel-B injections in patients with Hypoplastic Left Heart Syndrome is currently active but not recrui…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: National Collaborative to Improve Care of Children With Complex Congenital Heart Disease
This clinical trial update shows that the National Collaborative to Improve Care of Children With Complex Congenital Heart Disease is curren…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: NIRS in Congenital Heart Defects - Correlation With Echocardiography
Clinical trial update on a McGill-led study assessing near-infrared spectroscopy (NIRS) in congenital heart defects and its correlation with…
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CLINICAL_TRIALS research · 2025-03-21Clinical Trial Update: Effect of Fetal Aortic Valvuloplasty on Outcomes
A clinical trial update indicates ongoing recruitment for a study evaluating the effect of fetal aortic valvuloplasty on outcomes in fetuses…
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CLINICAL_TRIALS research · 2025-03-10Clinical Trial Update: Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS) [Phase 1]
A Phase 1 pediatric trial conducted by Emory University will assess the safety and feasibility of intramyocardial injection of VentriGel, a …
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CLINICAL_TRIALS trial_result · 2025-01-10Clinical Trial Update: Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients [NA]
A completed Mayo Clinic clinical trial update describing methods for umbilical cord blood collection and processing in patients with Hypopla…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease
This clinical trial update notes recruitment for an integrated prenatal and postnatal treatment model for newborns with critical congenital …
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Cerebral Anatomy, Hemodynamics and Metabolism
The clinical trial update covers cerebral anatomy, hemodynamics, and metabolism in Hypoplastic Left Heart Syndrome and notes the study has c…
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CLINICAL_TRIALS trial_result · 2024-10-21Clinical Trial Update: Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation
A clinical trial evaluating subendocardial viability after Norwood palliation for hypoplastic left heart syndrome has been terminated.
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CLINICAL_TRIALS trial_result · 2024-06-18Clinical Trial Update: Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period [NA]
A neonatal clinical trial targeting normoxia during intraoperative and immediate postoperative periods in cyanotic congenital heart disease …
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CLINICAL_TRIALS trial_result · 2024-05-23Clinical Trial Update: Use of Oxandrolone to Promote Growth in Infants With HLHS [Phase 1, Phase 2]
A Phase 1/2 trial evaluating oxandrolone to promote growth in infants with Hypoplastic Left Heart Syndrome has been terminated.
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome [Phase 1]
Phase 1 safety and feasibility study of umbilical cord blood cells in infants with Hypoplastic Left Heart Syndrome; the study was terminated…
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CLINICAL_TRIALS trial_result · 2024-03-26Clinical Trial Update: Maternal Hyperoxygenation in Congenital Heart Disease [Phase 1, Phase 2]
Clinical trial update on maternal hyperoxygenation for congenital heart disease (hypoplastic left heart syndrome) across Phase 1 and Phase 2…
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CLINICAL_TRIALS trial_result · 2023-10-04Clinical Trial Update: Lomecel-B Delivered During Stage II Surgery for Hypoplastic Left Heart Syndrome (ELPIS) [Phase 1, Phase 2]
Phase 1/2 clinical trial update for Lomecel-B delivered during stage II surgery in hypoplastic left heart syndrome (HLHS).
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CLINICAL_TRIALS trial_result · 2023-04-21Clinical Trial Update: Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle [Phase 1, Phase 2]
A clinical trial update for a mesenchymal stem cell therapy in single ventricle/anomalous left ventricle conditions is ongoing (Phase 1/Phas…
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CLINICAL_TRIALS trial_result · 2021-12-07Clinical Trial Update: Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease (PERSEUS) [Phase 2]
Phase 2 clinical trial evaluating cardiac progenitor cell infusion for univentricular heart disease has completed.