Hyponatremia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2014-05-02Clinical Trial Update: Study to Compare Conivaptan Pharmacokinetics in Subjects With Mild & Moderate Kidney Function Impairment to Subjects With Normal Kidney Function [Phase 1]
This completed Phase 1 study assesses how kidney function affects the pharmacokinetics of conivaptan, comparing mild/moderate impairment to …
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CLINICAL_TRIALS trial_result · 2014-05-02Clinical Trial Update: Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia [Phase 3]
This Phase 3 clinical trial update indicates that the intravenous agent YM087, sponsored by Cumberland Pharmaceuticals, completed a study as…
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CLINICAL_TRIALS trial_result · 2014-05-02Clinical Trial Update: Study of Efficacy & Safety of Oral YM087 in Subjects With Euvolemic or Hypervolemic Hyponatremia [Phase 3]
Phase 3 study evaluating the efficacy and safety of oral YM087 in adults with euvolemic or hypervolemic hyponatremia has completed.
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CLINICAL_TRIALS trial_result · 2014-02-07Clinical Trial Update: Effect of Tolvaptan on Cognitive Function in Cirrhosis [Phase 3]
A Phase 3 trial evaluating tolvaptan for cognitive function in patients with cirrhosis and hepatic encephalopathy, including cases associate…
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CLINICAL_TRIALS trial_result · 2013-08-26Clinical Trial Update: 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children [Phase 3]
Phase 3 trial comparing maintenance IV fluids—0.9% saline with 5% dextrose vs 0.45% saline with 5% dextrose—in hospitalized children with hy…
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CLINICAL_TRIALS trial_result · 2013-06-12Clinical Trial Update: Postoperative Hyponatremia - Are There Gender Differences? [NA]
A clinical trial update examining whether postoperative hyponatremia differs between genders.
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CLINICAL_TRIALS trial_result · 2013-06-05Clinical Trial Update: Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS [NA]
A completed clinical trial compares the incidence of hyponatremia between PEG-SD and PEG-ELS preparations (NCT01299779), as reported by Thom…
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CLINICAL_TRIALS trial_result · 2012-10-17Clinical Trial Update: Do Changes in Plasma Osmolality Influence Ventilation? [EARLY_Phase 1]
A completed early-phase clinical trial investigates whether changes in plasma osmolality affect ventilation.
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CLINICAL_TRIALS trial_result · 2012-06-13Clinical Trial Update: Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial [Phase 3]
Phase 3 trial comparing hypotonic versus isotonic parenteral fluids for hyponatremia and hypernatremia has completed; results were posted in…
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CLINICAL_TRIALS trial_result · 2012-05-03Clinical Trial Update: "SALT-2 Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia [Phase 3]
Phase 3 SALT-2 trial evaluating ascending doses of tolvaptan for hyponatremia has completed.
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CLINICAL_TRIALS trial_result · 2012-03-07Clinical Trial Update: 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children [NA]
Completed pediatric trial comparing maintenance IV fluids—0.9% sodium chloride with 5% dextrose vs 0.45% sodium chloride with 5% dextrose—in…
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CLINICAL_TRIALS trial_result · 2012-01-25Clinical Trial Update: Variation in Natremia Using Two Different Maintenance Intravenous Fluids in Postsurgical Hospitalized Children [Phase 3]
Phase 3 clinical trial comparing two maintenance intravenous fluids in postsurgical hospitalized children with hyponatremia; results on natr…
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CLINICAL_TRIALS trial_result · 2012-01-12Clinical Trial Update: The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
This clinical trial update describes the clinical and laboratory characteristics of recurrent drug-related hyponatremia, including hyponatre…
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CLINICAL_TRIALS trial_result · 2012-01-11Clinical Trial Update: Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia [Phase 2, Phase 3]
It describes a Phase 2/Phase 3 trial evaluating the efficacy and safety of tolvaptan tablets in patients with non-hypovolemic non-acute hypo…
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CLINICAL_TRIALS trial_result · 2011-10-26Clinical Trial Update: Post Operative Hyponatremia in the Renal Transplant Population
This Mayo Clinic-sponsored clinical trial evaluated post-operative hyponatremia in renal transplant patients and has completed, with results…
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CLINICAL_TRIALS trial_result · 2011-08-30Clinical Trial Update: Pseudohyponatremia of Multiple Myeloma is True Hyponatremia
A clinical trial update concludes that hyponatremia observed in patients with multiple myeloma is true hyponatremia rather than pseudohypona…
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CLINICAL_TRIALS trial_result · 2011-08-05Clinical Trial Update: Maintenance Intravenous Fluids in Children [Phase 3]
A Phase 3 trial evaluating maintenance intravenous fluids in children with hyponatremia has completed, with results posted in 2011.
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CLINICAL_TRIALS trial_result · 2011-07-06Clinical Trial Update: Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia
Completed clinical trial investigating how polymorphisms in the SLC12A3 gene (thiazide transporter) influence the development of hyponatremi…
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CLINICAL_TRIALS trial_result · 2011-06-28Clinical Trial Update: THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation [Phase 3]
Phase 3 clinical trial update on lixivaptan for treating hyponatremia in NYHA Class III/IV heart failure patients; study completed.
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CLINICAL_TRIALS trial_result · 2011-06-28Clinical Trial Update: Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia [Phase 3]
A Phase 3 multicenter, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of oral lixivaptan capsules in a…
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CLINICAL_TRIALS trial_result · 2011-06-21Clinical Trial Update: International, Multicenter Study of a Twenty-eight Week, Open-label, Titrated Oral Lixivaptan Administration in Patients With Chronic Hyponatremia: Extension to Studies CK-LX3401, 3405, and 3430
An international, multicenter extension study evaluated lixivaptan in patients with chronic hyponatremia and completed a 28-week open-label …
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CLINICAL_TRIALS trial_result · 2011-04-28Clinical Trial Update: Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients [Phase 3]
Phase 3 trial evaluating titrated oral tolvaptan (15-60 mg QD) on cognitive and neurological function in elderly patients with hyponatremia;…
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CLINICAL_TRIALS trial_result · 2011-04-26Clinical Trial Update: Subclassification of the Syndrome of Inappropriate ADH Secretion
This clinical trial update indicates completion of a study on subclassifying the syndrome of inappropriate antidiuretic hormone secretion (S…
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CLINICAL_TRIALS trial_result · 2010-10-01Clinical Trial Update: Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF) [Phase 3]
Phase 3 trial of conivaptan in hyponatremic patients with symptomatic acute decompensated heart failure was terminated; results were posted.
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CLINICAL_TRIALS trial_result · 2010-09-27Clinical Trial Update: Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients [Phase 4]
Phase 4 trial update on using conivaptan (Vaprisol) for hyponatremic neuro-ICU patients; study terminated with results posted in 2010.