Hyponatremia
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy? [NA]
Clinical trial update evaluating whether changing drug therapy benefits elderly patients with hyponatremia. The study status is completed.
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Hyponatremia - Complications, Prognosis, Epidemiology in Finnish Tertiary Care
The University of Turku is updating a clinical trial examining hyponatremia and its complications, including Osmotic Demyelination Syndrome …
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics [NA]
This clinical trial aims to validate new diagnostic indices to simplify hyponatremia therapy assessment in patients taking thiazide diuretic…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery [NA]
The study investigates whether protein supplementation combined with fluid restriction can influence plasma sodium levels in patients underg…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage [NA]
An ongoing clinical trial is evaluating crystalloid fluid choice and neurological outcomes in patients after subarachnoid hemorrhage, and is…
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CLINICAL_TRIALS trial_result · 2025-12-01Clinical Trial Update: Retrospective Analysis of ECG Changes and Arrhythmias in Patients With Profound Hyponatremia
This retrospective analysis examines electrocardiogram changes and arrhythmias in patients with profound hyponatremia. The study, sponsored …
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia [Phase 4]
Phase 4 clinical trial evaluating empagliflozin for euvolemic and hypervolemic hyponatremia (including SIADH); recruitment is ongoing at Uni…
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges [NA]
A clinical trial is exploring how extracellular sodium is regulated in end-stage renal disease during volume and electrolyte challenges and …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial
A prospective observational study sponsored by the University of Cologne to evaluate volume and electrolyte balance in the treatment of hypo…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Targeted Correction of Plasma Sodium Levels in Hospitalized Patients With Hyponatremia [NA]
A clinical trial studying targeted correction of plasma sodium levels in hospitalized patients with hyponatremia has completed.
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis [NA]
A clinical trial evaluating protein supplementation as a treatment for hyponatremia caused by the syndrome of inappropriate antidiuresis is …
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CLINICAL_TRIALS research · 2025-07-01Clinical Trial Update: Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia
A University Hospital Basel study is evaluating urinary prostaglandin as a potential predictor for thiazide-induced hyponatremia and is curr…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Influence of Serum Sodium Levels on Bone Metabolism and Turnover in Hospitalized Patients
A clinical trial conducted in hospitalized patients investigates how serum sodium levels influence bone metabolism and turnover; the study s…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Phase 2a Study for PK/PD of nC-001 [Phase 2]
A Phase 2a PK/PD study of nC-001 for chronic hyponatremia is planned, with recruitment not yet started.
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CLINICAL_TRIALS research · 2025-05-23Clinical Trial Update: Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia [Phase 3]
A Phase 3 clinical trial is evaluating the systematic use of desmopressin (DDAVP) to prevent serum sodium overcorrection in severe hyponatre…
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FDA approval · 2025-04-23FDA Approved: TOLVAPTAN — Original Application (Lupin Pharmaceuticals, Inc.)
FDA approved Lupin Pharmaceuticals' original application for tolvaptan (generic), enabling a generic version of the drug to be marketed.
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage [NA]
This clinical trial is evaluating urea therapy to treat hyponatremia in patients with subarachnoid hemorrhage; the study is currently active…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD [NA]
A completed clinical trial evaluating intravenous [Pyr1]Apelin-13 in healthy volunteers with artificially induced SIAD, focusing on effects …
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CLINICAL_TRIALS trial_result · 2025-03-28Clinical Trial Update: Asymptomatic Bacteriuria, Hyponatremia and Geri-atric Syndrome [NA]
This is a completed clinical trial update from Universitair Ziekenhuis Brussel examining asymptomatic bacteriuria in the context of hyponatr…
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EMA approval · 2025-03-26EMA Authorised: Samsca (tolvaptan) — Otsuka Pharmaceutical Netherlands B.V.
EMA authorised Samsca (tolvaptan) for the treatment of syndrome of inappropriate antidiuretic hormone secretion (SIADH), with Otsuka Pharmac…
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Delirium Related to Proton Pump Inhibitors Use
This completed trial evaluated delirium associated with proton pump inhibitor use and related hyponatremia as an adverse event.
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: A Phase 2 Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia [Phase 2]
Phase 2 trial evaluating the efficacy and safety of Tolvaptan tablets in patients with hypovolemic hyponatremia; the study has completed.
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CLINICAL_TRIALS trial_result · 2025-03-24Clinical Trial Update: Samsca Post-marketing General Drug Use-results Survey in Patients with Hyponatremia in SIADH
This clinical trial update discusses a post-marketing general drug use-results survey evaluating tolvaptan (Samsca) for hyponatremia associa…
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Albumin for Management of Hypervolemic Hyponatremia (AlbuCAT) [Phase 2]
Phase 2 trial (AlbuCAT) evaluating albumin for management of hypervolemic hyponatremia in patients with cirrhosis has completed.
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency Department
Ongoing clinical trial analysis of how hyponatremia relates to demyelination syndrome risk, including epidemiology, clinical presentation, a…