Hypertrophic Cardiomyopathy
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CLINICAL_TRIALS trial_result · 2026-08-20Clinical Trial Results: A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy [Phase 3]
Phase 3 trial results for mavacamten in non-obstructive hypertrophic cardiomyopathy have been completed with results posted.
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CLINICAL_TRIALS trial_result · 2026-08-05Clinical Trial Update: A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) [Phase 3]
Phase 3 trial evaluating efficacy and safety of aficamten versus placebo in adults with symptomatic non-obstructive hypertrophic cardiomyopa…
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CLINICAL_TRIALS trial_result · 2026-07-29Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy [Phase 3]
Phase 3 trial evaluating the efficacy and safety of sotagliflozin in symptomatic obstructive and non-obstructive hypertrophic cardiomyopathy…
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CLINICAL_TRIALS trial_result · 2026-06-02Clinical Trial Results: A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy [Phase 2]
Phase 2 trial evaluating MYK-224 for symptomatic obstructive hypertrophic cardiomyopathy was terminated; results posted.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Effectiveness and Treatment Patterns of Mavacamten in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan (MANAGE-HCM)
This clinical trial update covers mavacamten for obstructive hypertrophic cardiomyopathy in Japan. The study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy
The clinical trial update indicates that the mavacamten study in adults with obstructive hypertrophic cardiomyopathy has been completed, wit…
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EMA approval · 2026-04-16EMA Authorised: Myqorzo (aficamten) — Cytokinetics (Ireland) Limited
The European Medicines Agency authorised Myqorzo (aficamten) for the treatment of hypertrophic cardiomyopathy.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Perfusion Abnormalities in Hypertrophic Cardiomyopathy
This clinical trial update reports on perfusion abnormalities in hypertrophic cardiomyopathy; the study is currently active but not recruiti…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). [Phase 2, Phase 3]
Cytokinetics is conducting a Phase 2/3 clinical trial to evaluate aficamten in pediatric patients with symptomatic obstructive hypertrophic …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China
A study to assess the real-world effectiveness of mavacamten in adult patients with obstructive hypertrophic cardiomyopathy in China is curr…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Mechanisms of Atrial Pathoelectrophysiology in HCM
Clinical trial update investigating the mechanisms of atrial pathoelectrophysiology in hypertrophic cardiomyopathy and atrial fibrillation; …
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM [Phase 1, Phase 2]
Tenaya Therapeutics announced a multi-center, open-label Phase 1/2 trial to evaluate safety and tolerability of TN-201 in adults with MYBPC3…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Valsalva SBP Drop and LVOT Obstruction
This clinical trial update notes a Valsalva-induced drop in systolic blood pressure and left ventricular outflow tract obstruction in hypert…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From Athlete's
This clinical trial evaluates an artificial intelligence-enabled ECG approach using ECG devices to distinguish hypertrophic cardiomyopathy f…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: HCMR Re-Imaging Study
The HCMR Re-Imaging Study is currently recruiting participants for Hypertrophic Cardiomyopathy.
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia [NA]
Clinical trial update comparing catheter ablation to anti-arrhythmic drugs for ventricular tachycardia is active but not recruiting, involvi…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Empagliflozin in Hypertrophic Cardiomyopathy [Phase 3]
Phase 3 trial update shows empagliflozin is being investigated for hypertrophic cardiomyopathy and heart failure, with the study currently a…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases [Phase 1, Phase 2]
This clinical trial update reports ongoing Phase 1/2 studies evaluating the Ga-68-labeled NI-FAPI-04 PET/CT imaging agent for fibroblast act…
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: ENABLE-HCM - AI-ENabled Echocardiography With Ultrasound Beyond the Echo Lab for Better HCM Imaging and Expanded Access
The ENABLE-HCM trial evaluating AI-enabled echocardiography for hypertrophic cardiomyopathy imaging has been terminated.
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) [Phase 4]
A Phase 4 clinical trial in India evaluating mavacamten for symptomatic obstructive hypertrophic cardiomyopathy is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of sotagliflozin in symptomatic hypertrophic cardiomyopathy, including both obst…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Biological Collection for the Purpose of Exploring Genetic and Clinical-biological Factors Associated With Variability in Response to Mavacamten in the Treatment of Obstructive Hypertrophic Cardiomyopathy
This clinical trial update describes a biological sample collection study to explore genetic and clinical-biological factors that influence …
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Study of EDG-7500 in Adults With Hypertrophic Cardiomyopathy (CIRRUS-HCM) [Phase 2]
This is a Phase 2 clinical trial update on EDG-7500 for adults with hypertrophic cardiomyopathy (CIRRUS-HCM), noting that the study is curre…
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CLINICAL_TRIALS trial_result · 2026-02-24Clinical Trial Update: Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 in Adults With Hypertrophic Cardiomyopathy [Phase 2]
A Phase 2 dose-finding study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-3773274 in adults with hypertr…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: French Registry: Late Gadolinium Enhancement in Hypertrophic Cardiomyopathy
This ClinicalTrials.gov registry update indicates that the French study on Late Gadolinium Enhancement in Hypertrophic Cardiomyopathy is not…