Hypertriglyceridemia
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CLINICAL_TRIALS trial_result · 2026-08-06Clinical Trial Update: Study of Plozasiran in Adults With Severe Hypertriglyceridemia [Phase 3]
Phase 3 clinical trial update for Plozasiran in adults with severe hypertriglyceridemia.
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FDA approval · 2026-08-04FDA Approved: FENOFIBRATE — Supplemental Application (Bostal LLC)
Supplemental approval for fenofibrate from Bostal LLC.
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CLINICAL_TRIALS trial_result · 2026-07-15Clinical Trial Update: Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia [Phase 3]
Phase 3 trial of Plozasiran (ARO-APOC3) in adults with severe hypertriglyceridemia is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-07-07Clinical Trial Update: To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia [Phase 3]
Phase 3 trial update assessing efficacy and safety of pegozafermin in adults with severe hypertriglyceridemia completed.
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CLINICAL_TRIALS trial_result · 2026-06-26Clinical Trial Update: Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia [Phase 3]
Phase 3 clinical trial update for Plozasiran in adults with hypertriglyceridemia. Status is active not recruiting.
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CLINICAL_TRIALS trial_result · 2026-06-17Clinical Trial Update: To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia [Phase 3]
A Phase 3 trial evaluating the efficacy and safety of pegozafermin in subjects with severe hypertriglyceridemia has completed.
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia [Phase 2]
Phase 2 study of olezarsen (formerly AKCEA-APOCIII-LRx) in adults with hypertriglyceridemia and atherosclerotic cardiovascular disease or se…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia [Phase 2]
A Phase 2 study evaluating Solbinsiran (LY3561774) in participants with severe hypertriglyceridemia is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition [NA]
This clinical trial is investigating whether foods rich in omega-3 polyunsaturated fatty acids affect triglyceride levels and lipoprotein co…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: WB-EMS Effects on Cardiometabolic Risk Factors [NA]
A university-sponsored clinical trial is evaluating the effects of WB-EMS on cardiometabolic risk factors in adults with hypertension and me…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia [Phase 3]
A Phase 3 clinical trial is evaluating the long-term safety and efficacy of Plozasiran in adults with hypertriglyceridemia, with recruitment…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Russian Extreme Hypertriglyceridemia Registry
This entry notes that the Russian Extreme Hypertriglyceridemia Registry is actively recruiting participants to study severe hypertriglycerid…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: First-in-Human Study of ISH0688: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics [Phase 1]
First-in-human Phase 1 trial of ISH0688 evaluates safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy subjects and indiv…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: Study to Evaluate ARO-APOC3 in Adults With Severe Hypertriglyceridemia [Phase 2]
Phase 2 study evaluating ARO-APOC3 in adults with Severe Hypertriglyceridemia has completed and posted results.
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias [Phase 1]
The trial is a Phase 1 safety and tolerability study of CTX310 in participants with refractory dyslipidemias. It is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Single-ascending Dose Study of Kylo-12 in Healthy Subjects [Phase 1]
Phase 1 single-ascending-dose study of Kylo-12 in healthy subjects to assess safety and pharmacokinetics for hypertriglyceridemia; the trial…
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EMA approval · 2026-03-13EMA Authorised: Vazkepa (Icosapent ethyl) — Recordati Industria Chimica e Farmaceutica S.p.A.
EMA authorised Vazkepa (icosapent ethyl) for the treatment of dyslipidemias; the marketing authorization holder is Recordati Industria Chimi…
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FDA approval · 2026-03-11FDA Approved: FENOFIBRIC ACID — Supplemental Application (Alembic Pharmaceuticals Limited)
FDA approved a supplemental application for Fenofibric acid by Alembic Pharmaceuticals Limited.
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Phase II Clinical Trial Evaluating the Efficacy and Safety of HRS-7249 and SHR-1918 in Patients With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis [Phase 2]
A Phase II clinical trial is evaluating the efficacy and safety of HRS-7249 and SHR-1918 in adults with severe hypertriglyceridemia at high …
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CLINICAL_TRIALS other · 2026-03-03Clinical Trial Update: Treatment Protocol of Plozasiran in Adults With High-Risk Severe Hypertriglyceridemia (SHTG) and in Adults and Adolescents With FCS
ClinicalTrials.gov update describes the treatment protocol for the investigational drug Plozasiran in adults with high-risk severe hypertrig…
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: Long-term Comparison of Pitavastatin/Ezetimibe and Pitavastatin in Patients With Hypercholesterolemia and Elevated Triglycerides [Phase 4]
Phase 4 trial comparing long-term outcomes of pitavastatin/ezetimibe versus pitavastatin alone in patients with hypercholesterolemia and ele…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque [NA]
Clinical trial evaluating the efficacy and safety of DR10624 in patients with hypertriglyceridemia and carotid atherosclerosis is currently …
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food [NA]
A pilot clinical trial investigating Bottarga supplementation is currently recruiting to evaluate effects on metabolic conditions.
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe Hypertriglyceridemia [Phase 3]
Phase 3 clinical trial of olezarsen (ISIS 678354) in participants with hypertriglyceridemia and atherosclerotic cardiovascular disease, or w…
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CLINICAL_TRIALS trial_result · 2026-02-10Clinical Trial Update: A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia [Phase 3]
Ionis Pharmaceuticals reports that the Phase 3 trial of olezarsen (ISIS 678354) in adults with severe hypertriglyceridemia has completed. Th…