Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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EMA approval · 2025-12-15EMA Authorised: Repatha (Evolocumab) — Amgen Europe B.V.
EU regulators authorised Repatha (evolocumab) for dyslipidemias and hypercholesterolemia; decision date 12/12/2025.
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: A Phase II Study to Evaluate the Safety and Efficacy of SAL003 Combined With Atorvastatin in Hypercholesterolemia and Mixed Dyslipidemia [Phase 2]
This update reports the completion of a Phase II study evaluating the safety and efficacy of SAL003 in combination with atorvastatin for hyp…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Activate Tennessee: A CHW-Supported Program for Patient Activation [NA]
This ClinicalTrials.gov entry describes a CHW-supported program in Tennessee aimed at activating patients with diabetes and hypertension, wi…
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CLINICAL_TRIALS trial_result · 2025-12-11Clinical Trial Update: A Phase III Confirmatory Study of K-877 (Pemafibrate) in Patients With Hypercholesterolemia and Statin Intolerance [Phase 3]
This Clinical Trial Update notes a Phase III confirmatory study of pemafibrate (K-877) for hypercholesterolemia in statin-intolerant patient…
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CLINICAL_TRIALS trial_result · 2025-12-08Clinical Trial Update: A Study to Investigate the Effectiveness and Safety of Bempedoic Acid in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia in Taiwan [Phase 4]
This Phase 4 clinical trial evaluating the effectiveness and safety of bempedoic acid in adults with primary hypercholesterolemia or mixed d…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol [Phase 4]
A Phase 4 trial comparing dual versus triple lipid-lowering therapy in adults with type 2 diabetes and elevated LDL cholesterol; recruitment…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Safety and Efficacy of SAL003 in Combination With Statin Therapy in Patients With Hypercholesterolemia and Mixed Dyslipidemia [Phase 3]
A multicenter, randomized Phase III trial evaluated SAL003 in combination with statin therapy for hyperlipidemia and mixed dyslipidemia and …
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)
This clinical trial evaluates a strategy using carotid and coronary imaging to identify asymptomatic individuals at very high cardiovascular…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia [Phase 1]
A Phase 1b clinical trial evaluating VERVE-201 for patients with refractory hyperlipidemia is currently recruiting to assess safety and phar…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: The Effect of a Digital Heart Health App and Lifestyle Intervention for Heart Disease in Primary Care. [NA]
A clinical trial evaluating a digital heart health app plus lifestyle intervention for patients with cardiovascular disease in primary care,…
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CLINICAL_TRIALS trial_result · 2025-11-25Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Co-administrated BR1018B and BR1018C [Phase 3]
The document reports the completion of a Phase 3 clinical trial evaluating the efficacy and safety of co-administered BR1018B and BR1018C. T…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Effect of Sunflower Seed Consumption on Blood Cholesterol Levels in Adults [NA]
A completed clinical trial examined whether daily sunflower seed consumption affects blood cholesterol levels in adults with hypercholestero…
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CLINICAL_TRIALS trial_result · 2025-10-08Clinical Trial Update: Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies [Phase 3]
Phase 3 study evaluating a fixed-dose combination of obicetrapib and ezetimibe added to existing lipid-modifying therapy has completed. Resu…
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CLINICAL_TRIALS trial_result · 2025-10-07Clinical Trial Update: Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension [Phase 3]
Open-label extension of a Phase 3 trial evaluating Enlicitide Decanoate (MK-0616) for hypercholesterolemia, with ACTIVE_NOT_RECRUITING statu…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults [NA]
A clinical trial investigating whether herring oil concentrate affects LDL cholesterol levels in adults with hypercholesterolemia. The study…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: A Study to Evaluate the Safety and Pharmacokinetics of AD-228A Compared to Coadministration of AD-2281 and AD-2282 [Phase 1]
A Phase 1 clinical trial update reports on safety and pharmacokinetics evaluation of AD-228A versus coadministration of AD-2281 and AD-2282 …
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication. [NA]
This clinical trial update describes a tool to help patients manage muscle symptoms associated with statin medications.
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: A Study to Evaluate the Efficacy and the Safety of Single Pill Combination (SPC) Ezetimibe/Rosuvastatin in Chinese Adult Patients With Primary Hypercholesterolemia Not Adequately Controlled on Statin Therapy [Phase 3]
Phase 3 trial evaluating the efficacy and safety of a single-pill combination ezetimibe/rosuvastatin in Chinese adults with primary hypercho…
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies [Phase 3]
Phase 3 randomized study evaluating obicetrapib added to maximum tolerated lipid-modifying therapies has completed, with results posted.
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: Study To Evaluate The Efficacy And Safety Of A Nutritional Supplement Based On Bergamot, Artichoke And Other Ingredients For Reducing Cholesterol Levels In Patients With Hypercholesterolemia (Metachol+) [NA]
A clinical trial evaluating the efficacy and safety of a bergamot- and artichoke-based nutritional supplement (Metachol+) to reduce choleste…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: An OS to Evaluate the Safety & Efficacy of Fixed Dose Combination Therapy With Atorvastatin and Ezetimibe
This clinical trial update reports on a completed study evaluating the safety and efficacy of a fixed-dose combination of atorvastatin and e…
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CLINICAL_TRIALS trial_result · 2025-09-12Clinical Trial Update: Bioequivalence Study of Bempedoic Acid 180 mg Film Coated Tablet and Nilemdo® (Bempedoic Acid) 180 mg Film-coated Tablets [Phase 1]
Phase 1 bioequivalence study comparing bempedoic acid 180 mg film-coated tablets with Nilemdo 180 mg film-coated tablets has completed.
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Fixed-Dose Combination of Pitavastatin/Ezetimib
Recruiting update for a fixed-dose combination of pitavastatin and ezetimibe to evaluate efficacy and safety in primary hypercholesterolemia…
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CLINICAL_TRIALS trial_result · 2025-09-10Clinical Trial Update: A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids [Phase 3]
Phase 3 trial update for Enlicitide Decanoate (MK-0616), an oral PCSK9 inhibitor, in adults with hypercholesterolemia, including familial hy…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Church-based Health Intervention to Eliminate Racial Inequalities in Cardiovascular Health [NA]
Tulane University is recruiting participants for a church-based health intervention intended to eliminate racial disparities in cardiovascul…