Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2015-10-05Clinical Trial Update: A Study to Evaluate Tolerability and Efficacy of Evolocumab (AMG 145) in Japanese Subjects [Phase 2]
Phase 2 trial update evaluating tolerability and efficacy of evolocumab (AMG 145) in Japanese subjects with hypercholesterolemia and high ri…
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CLINICAL_TRIALS trial_result · 2015-10-05Clinical Trial Update: Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels [Phase 2]
Phase 2 trial update on a monoclonal antibody targeting PCSK9 to lower LDL-C in adults not on lipid therapy; study completed with results po…
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CLINICAL_TRIALS trial_result · 2015-09-30Clinical Trial Update: IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) [Phase 3]
This document reports the completion and results posting of the IMPROVE-IT Phase 3 trial comparing Vytorin (ezetimibe/simvastatin) to simvas…
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CLINICAL_TRIALS trial_result · 2015-09-29Clinical Trial Update: Durable Effect of PCSK9 Antibody CompARed wiTh placEbo Study [Phase 3]
Phase 3 trial update comparing a PCSK9 antibody with placebo in hypercholesterolemia completed with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-09-24Clinical Trial Update: Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) When Co-administered With High Dose of Atorvastatin in Patients With Primary Hypercholesterolemia [Phase 2]
Phase 2 study evaluating the efficacy and safety of alirocumab co-administered with high-dose atorvastatin in patients with hypercholesterol…
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CLINICAL_TRIALS trial_result · 2015-09-24Clinical Trial Update: Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy in Japan [Phase 2]
This Phase 2 study evaluated the efficacy and safety of alirocumab (SAR236553/REGN727) in Japanese patients with primary hypercholesterolemi…
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CLINICAL_TRIALS trial_result · 2015-09-24Clinical Trial Update: Efficacy and Safety Evaluation of Alirocumab (SAR236553/REGN727) in Patients With Primary Hypercholesterolemia on Stable Atorvastatin Therapy [Phase 2]
Phase 2 trial evaluating the efficacy and safety of alirocumab in patients with primary hypercholesterolemia on stable atorvastatin therapy;…
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CLINICAL_TRIALS trial_result · 2015-09-22Clinical Trial Update: Study of the Safety and Efficacy of REGN727/SAR236553 in Patients With HeFH Hypercholesterolemia [Phase 2]
Phase 2 study evaluating the safety and efficacy of evolocumab (REGN727/SAR236553) in heterozygous familial hypercholesterolemia; the trial …
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CLINICAL_TRIALS trial_result · 2015-09-22Clinical Trial Update: Efficacy/Safety of HCP1306 Tablet Versus HGP0816 Tablet in Patients With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial comparing HCP1306 versus HGP0816 tablets in patients with primary hypercholesterolemia has completed. The update provides info…
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CLINICAL_TRIALS trial_result · 2015-08-31Clinical Trial Update: Study of the Efficacy and Safety of Alirocumab (REGN727/SAR236553) in Combination With Other Lipid-modifying Treatment (LMT) (ODYSSEY OPTIONS I) [Phase 3]
Phase 3 trial results for alirocumab in combination with other lipid-modifying therapy in hypercholesterolemia; the study completed with res…
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CLINICAL_TRIALS trial_result · 2015-08-28Clinical Trial Update: Study of Alirocumab (REGN727/SAR236553) in Patients With Primary Hypercholesterolemia and Moderate, High, or Very High Cardiovascular (CV) Risk, Who Are Intolerant to Statins (ODYSSEY ALTERNATIVE) [Phase 3]
Phase 3 trial results for alirocumab in statin-intolerant patients with primary hypercholesterolemia and high cardiovascular risk have been …
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CLINICAL_TRIALS trial_result · 2015-08-28Clinical Trial Update: One-Day Acceptance and Commitment Training Intervention in Primary Care Patients [NA]
A completed clinical trial evaluated a one-day Acceptance and Commitment Training intervention for primary care patients. Results were poste…
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CLINICAL_TRIALS trial_result · 2015-08-14Clinical Trial Update: Effect of Statin Treatment on Urinary AQP2 (uAQP2/01)
A completed clinical trial investigates the effect of statin treatment on urinary aquaporin-2 (uAQP2).
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CLINICAL_TRIALS trial_result · 2015-08-03Clinical Trial Update: Using Nudges to Implement Comparative Effectiveness
A completed study from NYU Langone Health investigates how behavioral nudges can facilitate the implementation of comparative effectiveness …
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CLINICAL_TRIALS trial_result · 2015-07-27Clinical Trial Update: Lipid Efficacy/Tolerability Study (0524A-020) [Phase 3]
A Phase 3 trial evaluating lipid efficacy and tolerability (0524A-020) has completed. The study targeted primary hypercholesterolemia and mi…
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EMA approval · 2015-07-24Praluent recommended for approval to lower cholesterol
The European Medicines Agency recommended approval of Praluent (alirocumab) to lower cholesterol, pursuing a new indication.
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CLINICAL_TRIALS trial_result · 2015-07-15Clinical Trial Update: Retinoic Acid Supplementation and Subjects With Hypercholesterolemia [EARLY_Phase 1]
An early-phase 1 trial sponsored by Sun Yat-sen University evaluated retinoic acid supplementation in people with hypercholesterolemia and t…
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FDA approval · 2015-07-09FDA Approved: NIACIN — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
FDA approved a supplemental application for NIACIN (nicotinic acid) from Sun Pharmaceutical Industries, Inc., relating to an additional appr…
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CLINICAL_TRIALS trial_result · 2015-07-01Clinical Trial Update: Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluated the effectiveness of Nigella sativa seed for dyslipidemia; the study, conducted by Aga Khan University,…
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CLINICAL_TRIALS trial_result · 2015-06-18Clinical Trial Update: The Effect of Shuhua Milk Fortified With Plant Sterol Esters on Serum Cholesterol in Human [NA]
Completed clinical trial evaluating whether Shuhua Milk fortified with plant sterol esters lowers serum cholesterol in adults with hyperchol…
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CLINICAL_TRIALS trial_result · 2015-06-02Clinical Trial Update: Comparison of the Efficacy of Plant Sterol-Enriched Soymilk Versus Plain Soymilk in Volunteers With High LDL-Cholesterol [NA]
A completed clinical trial sponsored by Chiang Mai University compared plant sterol-enriched soymilk with plain soymilk in adults with high …
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CLINICAL_TRIALS research · 2015-05-28Clinical Trial Update: Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes [Phase 4]
Clinical trial update involving atorvastatin and aspirin examining oxidative stress, coagulation, and platelet activation indexes in patient…
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CLINICAL_TRIALS trial_result · 2015-05-21Clinical Trial Update: Statins in Children With Type 1 Diabetes and Hypercholesterolemia [Phase 3]
Phase 3 trial update on statin use in children with Type 1 diabetes and hypercholesterolemia; results completed and posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-05-15Clinical Trial Update: Efficacy/Safety of DP-R207 Tablet Versus CRESTOR Tablet in Patients With Primary Hypercholesterolemia [Phase 3]
Phase 3 trial comparing DP-R207 tablet to CRESTOR tablet in adults with primary hypercholesterolemia to assess efficacy and safety; the stud…
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CLINICAL_TRIALS trial_result · 2015-05-07Clinical Trial Update: Pharmacokinetic And Pharmacodynamic Study Of A Single-Dose Of PF-04950615 (RN316) In Combination With Atorvastatin [Phase 1]
A Phase 1 pharmacokinetic and pharmacodynamic study evaluated a single dose of PF-04950615 (RN316) in combination with atorvastatin in indiv…