Hypercholesterolemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2016-01-12Clinical Trial Update: Diet and Exercise for Elevated Risk (DEER) [Phase 3]
Stanford University-sponsored Phase 3 trial evaluating diet and exercise for individuals at elevated cardiovascular risk has completed.
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CLINICAL_TRIALS research · 2016-01-08Clinical Trial Update: A Study to Design a Model Cohort for Analysis of Dyslipidemia (MK-0653A-204)
This completed study outlines the design of a model cohort for analyzing dyslipidemia and related hypercholesterolemia. The sponsor was Orga…
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CLINICAL_TRIALS trial_result · 2016-01-07Clinical Trial Update: Evaluation of the Effects of Simvastatin 40mg [Phase 4]
This update reports the completion of a Phase 4 trial evaluating the effects of simvastatin 40 mg in individuals with hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2016-01-01Clinical Trial Update: Addition of Ezetimibe (Ezetrol®) to Ongoing Therapy With Rosuvastatin (Crestor®) in HIV Positive Patients Not Reaching Cholesterol Targets [NA]
A completed clinical trial evaluated adding ezetimibe to ongoing rosuvastatin therapy in HIV-positive patients not reaching cholesterol targ…
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CLINICAL_TRIALS trial_result · 2015-12-29Clinical Trial Update: Safety Study of AEM-28 to Treat Refractory Hypercholesterolemia [Phase 1, Phase 2]
Phase 1/2 safety study of AEM-28 for refractory hypercholesterolemia completed; results were posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-12-23Clinical Trial Update: Study to Assess in Home Use of Evolocumab (AMG 145) Administration Using Either an Automated Mini-doser or a Prefilled Autoinjector/Pen [Phase 3]
Phase 3 trial assessing in-home administration of evolocumab (AMG 145) using automated mini-doser or prefilled autoinjector/pen in patients …
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CLINICAL_TRIALS trial_result · 2015-12-23Clinical Trial Update: Evaluating Strategies to Control Hypercholesterolemia
A completed clinical trial evaluating strategies to control hypercholesterolemia.
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CLINICAL_TRIALS trial_result · 2015-12-23Clinical Trial Update: Study of Children's Activity and Nutrition (SCAN)
The SCAN trial (Study of Children’s Activity and Nutrition) sponsored by Augusta University has completed, investigating cardiovascular risk…
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CLINICAL_TRIALS trial_result · 2015-12-22Clinical Trial Update: Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term) [Phase 3]
Phase 3 long-term safety and tolerability results for alirocumab (Praluent) versus placebo on background lipid-lowering therapy in high-risk…
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CLINICAL_TRIALS trial_result · 2015-12-22Clinical Trial Update: The Effect of Synching Prescription Refills on Adherence [NA]
The University of Pennsylvania clinical trial evaluated whether syncing prescription refills improves medication adherence in patients with …
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CLINICAL_TRIALS trial_result · 2015-12-21Clinical Trial Update: An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia [Phase 3]
An open-label extension of a Phase 3 trial assessing the long-term safety and efficacy of mipomersen in patients with familial hypercholeste…
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CLINICAL_TRIALS trial_result · 2015-12-18Clinical Trial Update: Improving the Quality of Patient Care by Using a Clinical Expert System. [NA]
Completed trial evaluating a clinical expert system intended to improve patient care, with results posted.
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CLINICAL_TRIALS trial_result · 2015-12-17Clinical Trial Update: A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C) [Phase 1]
Phase 1 clinical trial update on ALN-PCSSC in subjects with elevated LDL cholesterol (hypercholesterolemia); the study status is completed.
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CLINICAL_TRIALS trial_result · 2015-12-11Clinical Trial Update: Lipid-lowering Effect of Plant Stanol Ester Yoghurt Drinks [NA]
Completed clinical trial assessing the lipid-lowering effect of plant stanol ester yogurt drinks sponsored by Raisio Group.
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CLINICAL_TRIALS trial_result · 2015-11-24Clinical Trial Update: Medication Adherence With Polyglot Meducation [NA]
A completed clinical trial evaluated adherence to a polyglot medication regimen in patients with hypertension, diabetes mellitus, and hyperc…
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CLINICAL_TRIALS trial_result · 2015-11-06Clinical Trial Update: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Ezetimibe on Top of Statin in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY COMBO II) [Phase 3]
Phase 3 ODYSSEY COMBO II study comparing alirocumab vs ezetimibe on top of statin in high cardiovascular risk patients with hypercholesterol…
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CLINICAL_TRIALS trial_result · 2015-11-06Clinical Trial Update: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Ezetimibe in Patients With Hypercholesterolemia [Phase 3]
Phase 3 trial comparing alirocumab (Praluent) to ezetimibe in patients with hypercholesterolemia assessed efficacy and safety. The study res…
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CLINICAL_TRIALS trial_result · 2015-11-06Clinical Trial Update: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With High Cardiovascular Risk and Hypercholesterolemia (ODYSSEY COMBO I) [Phase 3]
Phase 3 ODYSSEY COMBO I evaluated alirocumab on top of lipid-modifying therapy in high-risk hypercholesterolemia; efficacy and safety result…
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FDA label_change · 2015-11-05FDA Approved: LESCOL XL — Supplemental Application (Sandoz Inc)
FDA approved a supplemental application for LESCOL XL (fluvastatin sodium) submitted by Sandoz Inc, resulting in labeling changes.
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CLINICAL_TRIALS trial_result · 2015-11-04Clinical Trial Update: Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy [Phase 3]
Phase 3 trial evaluating the efficacy and safety of Alirocumab added to lipid-modifying therapy in patients with heterozygous familial hyper…
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CLINICAL_TRIALS trial_result · 2015-10-29Clinical Trial Update: Lipid-lowering Effect of a Plant Stanol Ester Supplement Product [NA]
A completed clinical trial from Raisio Group assessing the lipid-lowering effect of a plant stanol ester supplement (Benecol).
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CLINICAL_TRIALS trial_result · 2015-10-28Clinical Trial Update: Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II) [Phase 3]
Phase 3 study evaluating alirocumab added to rosuvastatin versus other lipid-modifying treatments in hypercholesterolemia has completed with…
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CLINICAL_TRIALS trial_result · 2015-10-12Clinical Trial Update: Safety Study of BMS-823778 in Subjects With Hypercholesterolemia [Phase 2]
This clinical trial update reports the completion of a Phase 2 safety study of BMS-823778 in adults with hypercholesterolemia (dyslipidemia)…
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CLINICAL_TRIALS trial_result · 2015-10-09Clinical Trial Update: Study to Assess In-home Use of Evolocumab (AMG 145) Using a Prefilled Syringe or a Prefilled Autoinjector/Pen [Phase 3]
Phase 3 trial assessing in-home use of evolocumab via prefilled syringe or autoinjector; completed with posted results.
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FDA approval · 2015-10-06FDA Approved: ATORVASTATIN CALCIUM — Supplemental Application (Sun Pharmaceutical Industries Inc.)
The FDA approved a supplemental application for atorvastatin calcium from Sun Pharmaceutical Industries Inc., granting regulatory approval f…