Huntington Disease

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease [NA]

  The study evaluates brain-derived neurotrophic factor pathway biomarkers in the cerebrospinal fluid of patients with Huntington disease. Rec…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease [NA]

  A clinical trial evaluating home-based transcranial direct current stimulation for cognitive and behavioral symptoms in Huntington disease i…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease [NA]

  An open, home-based trial of transcranial direct current stimulation for behavioral and cognitive symptoms in Huntington disease is currentl…

• CLINICAL_TRIALS research · 2026-02-04
  Clinical Trial Update: Retinal Imaging in Neurodegenerative Disease

  This clinical trial update notes a Duke University-sponsored study evaluating retinal imaging as a biomarker across multiple neurodegenerati…

• CLINICAL_TRIALS research · 2026-01-29
  Clinical Trial Update: Hinting Task for Huntington's Disease

  A Huntington's disease clinical trial at University Medical Center Groningen is currently recruiting to evaluate a hinting task.

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• CLINICAL_TRIALS research · 2026-01-27
  Clinical Trial Update: Digital Measures for Clinical Trial Endpoints in Huntington's Disease

  A University of Rochester–led clinical trial is evaluating digital measures as endpoints in Huntington's disease and is currently recruiting…

• CLINICAL_TRIALS research · 2026-01-15
  Clinical Trial Update: The Safety and Tolerability Study With ER2001 Intravenous Injection Repetitive Treatment in Adults With Early Manifest Huntington's Disease. [EARLY_Phase 1]

  Clinical trial update on the safety and tolerability study of ER2001 intravenous injections in adults with early manifest Huntington's disea…

• CLINICAL_TRIALS research · 2026-01-14
  Clinical Trial Update: A Phase I Clinical Study of ER2001 Injection for the Treatment of Early Manifest Huntington's Disease. [Phase 1, Phase 2]

  A Phase I/II clinical trial update for ER2001 Injection in early manifest Huntington's disease, currently not recruiting.

• CLINICAL_TRIALS trial_result · 2026-01-13
  Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) [Phase 2]

  A Phase 2 study evaluating the safety and efficacy of PTC518 in Huntington's disease has completed. Results have been posted (2026-01-13) by…

• EMA withdrawal · 2026-01-09
  EMA Application withdrawn: Nurzigma (pridopidine hydrochloride) — Prilenia Therapeutics B.V.

  EMA has withdrawn the application for Nurzigma (pridopidine hydrochloride) by Prilenia Therapeutics B.V. for Huntington disease.

• CLINICAL_TRIALS research · 2026-01-05
  Clinical Trial Update: Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease

  A clinical trial update for a study on multi-modal digital monitoring of Huntington's disease symptoms, sponsored by BioSensics, currently n…

• CLINICAL_TRIALS trial_result · 2025-12-30
  Clinical Trial Update: Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease [NA]

  Johns Hopkins University completed a clinical trial evaluating a group drum-based music therapy intervention for Parkinson's disease and Hun…

• CLINICAL_TRIALS research · 2025-12-29
  Clinical Trial Update: Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD) [NA]

  This clinical trials update describes a study evaluating music therapy for irritability and impulsivity in Huntington's disease (MUSIC-HD). …

• CLINICAL_TRIALS research · 2025-12-23
  Clinical Trial Update: Is Caffeine an Environmental Modifier in Huntington's Disease?

  A completed clinical trial investigates whether caffeine acts as an environmental modifier in Huntington's disease.

• CLINICAL_TRIALS trial_result · 2025-12-23
  Clinical Trial Update: Project AWARE 2.0 to Improve Awareness, Willingness and Ability for Research and Enrollment in Clinical Research

  This entry reports the completion of Project AWARE 2.0, a Huntington Study Group trial aimed at improving awareness, willingness, and abilit…

• CLINICAL_TRIALS research · 2025-12-23
  Clinical Trial Update: Facilitating Effective Eating With DoddleBags: A Single-Arm Acceptability Study Of DoddleBags to Assess Impact on Self Feeding Behaviours in a Huntington's Disease Population [NA]

  A single-arm acceptability study recruiting Huntington's disease patients to evaluate the acceptability and impact of using DoddleBags to su…

• CLINICAL_TRIALS research · 2025-12-23
  Clinical Trial Update: Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease

  A clinical trial update for a study assessing neurodevelopment from childhood to adulthood in individuals with gene-expanded Huntington's di…

• CLINICAL_TRIALS trial_result · 2025-12-19
  Clinical Trial Update: The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest Huntington's Disease [EARLY_Phase 1]

  Safety and tolerability results are reported for a Phase 1 intravenous study of ER2001 in adults with early manifest Huntington's disease; t…

• CLINICAL_TRIALS research · 2025-12-19
  Clinical Trial Update: HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

  HDClarity is a multi-site cerebrospinal fluid collection initiative to facilitate therapeutic development for Huntington's disease, and the …

• FDA approval · 2025-12-18
  FDA Approved: HALOPERIDOL — Original Application (Creekwood Pharmaceuticals LLC)

  FDA approved Creekwood Pharmaceuticals' generic haloperidol under an original ANDA (ANDA 218162).

• CLINICAL_TRIALS trial_result · 2025-12-17
  Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease [Phase 3]

  A Phase 3 trial evaluating the safety and tolerability of SAGE-718 in Huntington's disease was terminated, and results were posted on 2025-1…

• CLINICAL_TRIALS research · 2025-12-10
  Clinical Trial Update: Utilization of 31P-Nuclear Magnetic Resonance Spectroscopy to Monitor Brain Energy Deficit in Huntington Disease [NA]

  This clinical trial explored using 31P-NMR spectroscopy to monitor brain energy deficits in Huntington's disease. The study status is comple…

• CLINICAL_TRIALS research · 2025-12-10
  Clinical Trial Update: Social Cognition Training in Individuals With Huntington's Disease [NA]

  Clinical trial update indicates ongoing recruitment for a study of social cognition training in individuals with Huntington's disease, condu…

• CLINICAL_TRIALS research · 2025-11-21
  Clinical Trial Update: Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3) [NA]

  This clinical trial update outlines Aim 3 of a study evaluating a behavioral intervention to reduce anxiety by modifying threat interpretati…

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD) [Phase 2]

  An extension of a Phase 2 study to evaluate the long-term safety and efficacy of Votoplam in Huntington's disease.