Huntington Disease

• CLINICAL_TRIALS research · 2026-04-24
  Clinical Trial Update: An Extension of SKY-0515 in Participants With Huntington's Disease [Phase 2, Phase 3]

  An extension study of SKY-0515 for Huntington's disease is enrolling by invitation in Phase 2/Phase 3.

• CLINICAL_TRIALS research · 2026-04-23
  Clinical Trial Update: Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

  A clinical trial update describes development of non-invasive prenatal diagnosis for single-gene disorders. The study, based in Paris, is cu…

• CLINICAL_TRIALS research · 2026-04-22
  Clinical Trial Update: Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease [Phase 2, Phase 3]

  Skyhawk Therapeutics is conducting a Phase 2/3 trial of SKY-0515 in Huntington's disease, currently recruiting to evaluate safety, efficacy,…

• CLINICAL_TRIALS research · 2026-04-21
  Clinical Trial Update: Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease [Phase 2, Phase 3]

  A Phase 2/3 study of SKY-0515 for Huntington's disease is currently recruiting to evaluate pharmacodynamics, safety, and efficacy.

• CLINICAL_TRIALS research · 2026-04-17
  Clinical Trial Update: A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease [Phase 1, Phase 2]

  This document reports a randomized Phase 1/2 trial of SPK-10001 gene therapy for Huntington's disease, with participant recruitment underway…

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• CLINICAL_TRIALS research · 2026-04-17
  Clinical Trial Update: A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease [Phase 1]

  This clinical trial update reports the first-in-human Phase 1 study of SRP-1005 for Huntington's disease and indicates the study is not yet …

• CLINICAL_TRIALS research · 2026-04-16
  Clinical Trial Update: A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease [Phase 3]

  Phase 3 clinical trial update indicates Novartis is evaluating Votoplam for Huntington's disease. The study is currently recruiting.

• CLINICAL_TRIALS research · 2026-04-14
  Clinical Trial Update: Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease [Phase 2, Phase 3]

  Clinical trial update for a Phase 2/Phase 3 study evaluating deutetrabenazine (Austedo) in Huntington disease, focusing on functional speech…

• CLINICAL_TRIALS research · 2026-04-13
  Clinical Trial Update: Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating the safety and tolerability of human neural stem cells for Huntington's disease; currently recruiting.

• CLINICAL_TRIALS research · 2026-04-13
  Clinical Trial Update: Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease [NA]

  Clinical trial update on optimizing low-intensity focused ultrasound parameters for pallidal modulation in Huntington disease; currently not…

• CLINICAL_TRIALS research · 2026-04-06
  Clinical Trial Update: Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease [NA]

  A not-yet-recruiting clinical study sponsored by University Hospital Angers investigating autobiographical memory, future thought, and eye m…

• CLINICAL_TRIALS research · 2026-04-03
  Clinical Trial Update: Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

  A Roche-sponsored clinical trial is studying the frequency of selected single nucleotide polymorphisms in individuals who carry Huntington d…

• CLINICAL_TRIALS research · 2026-03-31
  Clinical Trial Update: A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease [Phase 1]

  A Phase 1 clinical trial update for ALN-HTT02 in adults with Huntington's disease. The study is currently recruiting and has not reported re…

• CLINICAL_TRIALS research · 2026-03-31
  Clinical Trial Update: Biology-Driven Cognitive Profiling in Huntington's Disease

  This clinical trial update notes an active, non-recruiting study investigating biology-driven cognitive profiling in Huntington's disease.

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease [Phase 1]

  A Phase 1 study evaluating RG6496 in Huntington's disease to assess safety, tolerability, pharmacokinetics, and pharmacodynamics, currently …

• CLINICAL_TRIALS research · 2026-03-17
  Clinical Trial Update: Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients [NA]

  This clinical trial update describes a study comparing two cognitive-motor rehabilitation approaches delivered via exergames to examine cogn…

• CLINICAL_TRIALS research · 2026-03-13
  Clinical Trial Update: iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009 [EARLY_Phase 1]

  This clinical trial update reports an early-phase 1 study to evaluate a novel mutant huntingtin PET radioligand labeled [11C]CHDI-00491009 f…

• CLINICAL_TRIALS research · 2026-03-13
  Clinical Trial Update: Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

  This clinical trial update describes ongoing recruitment for a longitudinal study assessing brain structure and function in juvenile-onset H…

• CLINICAL_TRIALS research · 2026-03-11
  Clinical Trial Update: Evaluation of Three Tests to Assess Social Cognition in Huntington Disease

  A clinical trial update evaluating three tests to assess social cognition in Huntington disease, currently recruiting.

• CLINICAL_TRIALS research · 2026-03-02
  Clinical Trial Update: Cognitive Assessment Tools for Huntington's Disease.

  A clinical trial update describes a study evaluating cognitive assessment tools for Huntington disease, currently recruiting at Ohio State U…

• CLINICAL_TRIALS research · 2026-03-02
  Clinical Trial Update: GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease [Phase 2]

  A Phase 2 clinical trial (GENERATION HD2) is evaluating safety, biomarkers, and efficacy of tominersen versus placebo in participants with p…

• CLINICAL_TRIALS research · 2026-02-12
  Clinical Trial Update: Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease [NA]

  The study evaluates brain-derived neurotrophic factor pathway biomarkers in the cerebrospinal fluid of patients with Huntington disease. Rec…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease [NA]

  A clinical trial evaluating home-based transcranial direct current stimulation for cognitive and behavioral symptoms in Huntington disease i…

• CLINICAL_TRIALS research · 2026-02-11
  Clinical Trial Update: Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease [NA]

  An open, home-based trial of transcranial direct current stimulation for behavioral and cognitive symptoms in Huntington disease is currentl…

• CLINICAL_TRIALS research · 2026-02-04
  Clinical Trial Update: Retinal Imaging in Neurodegenerative Disease

  This clinical trial update notes a Duke University-sponsored study evaluating retinal imaging as a biomarker across multiple neurodegenerati…