Huntington Disease

• CLINICAL_TRIALS trial_result · 2026-08-27
  Clinical Trial Results: Real World Effectiveness and Safety of Deutetrabenazine in Adult Chinese Participants With Huntington's Disease (HD) Chorea in China [Phase 4]

  Phase 4 trial assessing real-world effectiveness and safety of deutetrabenazine in adult Chinese participants with Huntington's disease-rela…

• CLINICAL_TRIALS trial_result · 2026-08-25
  Clinical Trial Results: An Open Label Study of ANX005 in Participants With, or at Risk for, Manifest Huntington's Disease [Phase 2]

  Phase 2 open-label trial results for ANX005 in participants with or at risk for Huntington's disease have been completed with results posted…

• CLINICAL_TRIALS trial_result · 2026-04-09
  Clinical Trial Update: Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada [Phase 3]

  Phase 3 long-term study to assess safety and tolerability of valbenazine in participants with chorea associated with Huntington disease in C…

• CLINICAL_TRIALS trial_result · 2026-04-08
  Clinical Trial Update: Mass Balance Study of [14C] LPM3770164 in Healthy Participants [Phase 1]

  Phase 1 mass balance pharmacokinetic study of [14C] LPM3770164 in healthy participants, sponsored by Luye Pharma Group Ltd.; Huntington dise…

• CLINICAL_TRIALS trial_result · 2026-01-13
  Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) [Phase 2]

  A Phase 2 study evaluating the safety and efficacy of PTC518 in Huntington's disease has completed. Results have been posted (2026-01-13) by…

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• CLINICAL_TRIALS trial_result · 2025-12-30
  Clinical Trial Update: Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease [NA]

  Johns Hopkins University completed a clinical trial evaluating a group drum-based music therapy intervention for Parkinson's disease and Hun…

• CLINICAL_TRIALS trial_result · 2025-12-23
  Clinical Trial Update: Project AWARE 2.0 to Improve Awareness, Willingness and Ability for Research and Enrollment in Clinical Research

  This entry reports the completion of Project AWARE 2.0, a Huntington Study Group trial aimed at improving awareness, willingness, and abilit…

• CLINICAL_TRIALS trial_result · 2025-12-19
  Clinical Trial Update: The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest Huntington's Disease [EARLY_Phase 1]

  Safety and tolerability results are reported for a Phase 1 intravenous study of ER2001 in adults with early manifest Huntington's disease; t…

• CLINICAL_TRIALS trial_result · 2025-12-17
  Clinical Trial Update: A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease [Phase 3]

  A Phase 3 trial evaluating the safety and tolerability of SAGE-718 in Huntington's disease was terminated, and results were posted on 2025-1…

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD) [Phase 2]

  An extension of a Phase 2 study to evaluate the long-term safety and efficacy of Votoplam in Huntington's disease.

• CLINICAL_TRIALS trial_result · 2025-11-18
  Clinical Trial Update: Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders [NA]

  A completed clinical trial evaluated the efficacy of virtual reality–based cognitive rehabilitation combined with computer-based cognitive s…

• CLINICAL_TRIALS trial_result · 2025-11-18
  Clinical Trial Update: Dance and Huntington Disease [NA]

  This entry notes the completion of a clinical trial investigating dance therapy for Huntington's disease. The brief update does not provide …

• CLINICAL_TRIALS trial_result · 2025-10-21
  Clinical Trial Update: Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease [Phase 1, Phase 2]

  This is a status update on a safety and proof-of-concept study of AMT-130 in adults with early manifest Huntington's disease, with the trial…

• CLINICAL_TRIALS trial_result · 2025-09-25
  Clinical Trial Update: TEsting METformin Against Cognitive Decline in HD [Phase 3]

  A Phase 3 trial evaluating metformin for cognitive decline in Huntington's disease has completed.

• CLINICAL_TRIALS trial_result · 2025-09-19
  Clinical Trial Update: Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease [Phase 2]

  Phase 2 dose-response study evaluating Cellavita HD in Huntington disease has completed with results posted.

• CLINICAL_TRIALS trial_result · 2025-09-17
  Clinical Trial Update: A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B [Phase 1]

  This is a completed Phase 1 study evaluating the safety, tolerability, and pharmacokinetics of SAGE-718 oral solution in patients with Hunti…

• CLINICAL_TRIALS trial_result · 2025-09-05
  Clinical Trial Update: A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD) [Phase 2]

  A Phase 2 clinical trial evaluating SAGE-718 for cognitive function in Huntington's disease has completed and results have been posted.

• CLINICAL_TRIALS trial_result · 2025-08-28
  Clinical Trial Update: Efficacy and Safety on SOM3355 in Huntington's Disease Chorea [Phase 2]

  A Phase 2 trial evaluating the efficacy and safety of SOM3355 in Huntington's disease chorea has completed, with results posted.

• CLINICAL_TRIALS trial_result · 2025-08-27
  Clinical Trial Update: 31P-MRS and Huntington Disease [NA]

  A completed clinical trial investigated phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in individuals with Huntington's disease, sp…

• CLINICAL_TRIALS trial_result · 2025-08-12
  Clinical Trial Update: Study of WVE-003 in Patients With Huntington's Disease [Phase 1, Phase 2]

  Phase 1/2 study of WVE-003 in Huntington's disease has completed and results have been posted.

• CLINICAL_TRIALS trial_result · 2025-05-28
  Clinical Trial Update: Effect of Tetrabenazine on Stroop Interference in HD [Phase 4]

  Phase 4 trial evaluating the effect of tetrabenazine on Stroop interference in Huntington disease has completed and results have been posted…

• CLINICAL_TRIALS trial_result · 2025-05-16
  Clinical Trial Update: Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD) [NA]

  This clinical trial update concerns the use of transcranial static magnetic stimulation (tSMS) for Huntington's disease. The study is curren…

• CLINICAL_TRIALS trial_result · 2025-05-16
  Clinical Trial Update: Couple and Spouse Caregiver in Huntington's Disease

  A clinical trial evaluating care for couples and spouses of individuals with Huntington's disease has been terminated.

• CLINICAL_TRIALS trial_result · 2025-05-06
  Clinical Trial Update: 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease [Phase 2]

  Phase 2 trial of SAGE-718 in Huntington's disease completed; results have been posted.

• CLINICAL_TRIALS trial_result · 2025-03-21
  Clinical Trial Update: Risperidone for the Treatment of Huntington's Disease Involuntary Movements [Phase 2]

  Phase 2 trial evaluating risperidone for involuntary movements in Huntington's disease (chorea) has completed with results posted.