Hepatitis C
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Treatment of Acute Hepatitis C Virus Infection With Pegylated Interferon in Injection Drug Users [Phase 4]
Phase 4 clinical trial update investigating pegylated interferon for acute hepatitis C virus infection in injection drug users; the study st…
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection [Phase 4]
This Clinical Trial Update reports results from a Phase 4 study evaluating liver transplantation for end-stage liver disease caused by chron…
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1 [NA]
A completed clinical trial update evaluating prevention of depression in methadone-maintenance patients receiving hepatitis C treatment. The…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug Users [Phase 3]
Phase 3 clinical trial update evaluating a Hepatitis B vaccine model used for HIV vaccine trials in drug users; the study status is complete…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Efficacy and Safety of Combination Grazoprevir (MK-5172)/Elbasvir (MK-8742) Versus Sofosbuvir + Pegylated Interferon + Ribavirin in Hepatitis C Virus Genotype 1, 4 or 6 Infection (MK-5172-077) [Phase 3]
Phase 3 trial comparing Grazoprevir/Elbasvir to Sofosbuvir+Pegylated Interferon+Ribavirin in Hepatitis C virus genotypes 1, 4, or 6; study c…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Study to Reduce Intravenous Exposures (STRIVE) [Phase 2, Phase 3]
The STRIVE study, a Phase 2/3 trial sponsored by the National Institute on Drug Abuse (NIDA) to reduce intravenous exposures, targets patien…
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CLINICAL_TRIALS trial_result · 2017-01-11Clinical Trial Update: Primary Prevention Hepatocellular Carcinoma by Metformin [Phase 3]
Phase 3 trial evaluating metformin for primary prevention of hepatocellular carcinoma in people with chronic liver disease, including chroni…
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FDA approval · 2017-01-10FDA Approved: ZEPATIER — Supplemental Application (Merck Sharp & Dohme LLC)
FDA approved a supplemental application for ZEPATIER (elbasvir and grazoprevir) from Merck Sharp & Dohme LLC.
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CLINICAL_TRIALS trial_result · 2017-01-10Clinical Trial Update: Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Participants With Chronic Genotype 1 HCV Who Participated in a Prior Gilead-Sponsored HCV Treatment Study [Phase 2]
Phase 2 trial update of Ledipasvir/Sofosbuvir fixed-dose combination with or without ribavirin in chronic genotype 1 HCV patients who had pr…
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CLINICAL_TRIALS withdrawal · 2017-01-09Clinical Trial Update: Use of Omega-3 Fatty Acids (Fish Oil) in Patients With Chronic Hepatitis C Infection [NA]
A clinical trial evaluating omega-3 fatty acids (fish oil) in patients with chronic hepatitis C has been withdrawn; no results are reported.
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CLINICAL_TRIALS trial_result · 2017-01-05Clinical Trial Update: A Study to Investigate the Pharmacokinetic Interactions Between Simeprevir and Ledipasvir in a Treatment Regimen Consisting of Simeprevir, Sofosbuvir, and Ledipasvir in Treatment-naive Participants With Chronic Hepatitis C Virus Genotype 1 Infection [Phase 2]
Phase 2 study evaluating pharmacokinetic interactions among Simeprevir, Ledipasvir, and Sofosbuvir in treatment-naive chronic hepatitis C ge…
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CLINICAL_TRIALS trial_result · 2016-12-29Clinical Trial Update: A Health Intervention to Prevent Depression Hepatitis C Patients [Phase 2, Phase 3]
The Phase 2/Phase 3 trial evaluating a health intervention to prevent depression in patients with Hepatitis C has been terminated.
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CLINICAL_TRIALS trial_result · 2016-12-29Clinical Trial Update: Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound
A completed clinical trial evaluated acoustic liver biopsy via endoscopic ultrasound in healthy individuals and in patients with cirrhosis t…
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CLINICAL_TRIALS trial_result · 2016-12-29Clinical Trial Update: Tailored Regimens of PEGASYS® and Ribavirin for Genotype 1 Chronic Hepatitis C Patients Trial (TARGET-1) [Phase 4]
Phase 4 clinical trial update on tailored regimens of PEGASYS and ribavirin for genotype 1 chronic hepatitis C, now completed.
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EMA guidance · 2016-12-16Direct-acting antivirals for hepatitis C: EMA confirms recommendation to screen for hepatitis B
EMA confirms recommendation to screen for hepatitis B when using direct-acting antivirals for hepatitis C.
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CLINICAL_TRIALS trial_result · 2016-12-16Clinical Trial Update: Pioglitazone in Hepatitis C [Phase 4]
A Phase 4 clinical trial evaluating pioglitazone for chronic hepatitis C has completed.
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CLINICAL_TRIALS trial_result · 2016-12-15Clinical Trial Update: The Study of Safety, Pharmacokinetics, Pharmacodynamics of Peglamda (Peginterferon Lamda 1) on Healthy Volunteers and the Preliminary Evaluation of Peglamda and Hepasig (Ribavirin) Treatment's Effects on Chronic Hepatitis C Patients [Phase 1]
Phase 1 trial update evaluating the safety, pharmacokinetics, and pharmacodynamics of Peglamda (peginterferon lambda-1) in healthy volunteer…
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CLINICAL_TRIALS trial_result · 2016-12-14Clinical Trial Update: Sofosbuvir/Velpatasvir Fixed-Dose Combination in Adults With Chronic HCV Infection and Child-Pugh Class B Cirrhosis [Phase 3]
Phase 3 trial evaluating sofosbuvir/velpatasvir fixed-dose combination in adults with chronic hepatitis C and Child-Pugh B cirrhosis has com…
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CLINICAL_TRIALS trial_result · 2016-12-14Clinical Trial Update: PoC-HCV Genedrive Viral Detection Assay Validation Study
A completed clinical trial updating validation results for the Genedrive PoC-HCV Viral Detection Assay used for Hepatitis C detection.
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CLINICAL_TRIALS trial_result · 2016-12-13Clinical Trial Update: Pilot Study Evaluating the Use of Simultaneous HBV, HCV, and HIV Rapid Tests [NA]
A pilot study evaluated the use of simultaneous rapid tests for HIV, hepatitis B, and hepatitis C; the trial is completed and results were p…
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CLINICAL_TRIALS trial_result · 2016-12-12Clinical Trial Update: Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Co-Administered With Sofosbuvir With and Without Ribavirin in Treatment-Naive HCV Genotype 1-Infected Adults [Phase 3]
Phase 3 study evaluating co-administration of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with and without Ribavirin in treatment-naive …
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CLINICAL_TRIALS trial_result · 2016-12-12Clinical Trial Update: New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis C [Phase 2]
A Phase 2 clinical trial reports treatment response in people with chronic hepatitis C, comparing outcomes in those with cirrhosis to those …
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CLINICAL_TRIALS trial_result · 2016-12-12Clinical Trial Update: An Observational Study Examining the Use of Triple Combination Therapy With Boceprevir, Peginterferon Alfa-2a and Ribavirin in the Re-Treatment of Chronic Hepatitis C Patients
An observational study evaluating the re-treatment of chronic hepatitis C with a triple therapy of boceprevir, peginterferon alfa-2a, and ri…
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CLINICAL_TRIALS trial_result · 2016-12-08Clinical Trial Update: Gradual Withdrawal of Immune System Suppressing Drugs in Patients Receiving a Liver Transplant [Phase 2]
A Phase 2 trial evaluating gradual withdrawal of immunosuppressive therapy in liver transplant recipients; results have been posted.
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CLINICAL_TRIALS trial_result · 2016-12-06Clinical Trial Update: Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination and Sofosbuvir + Ribavirin for Subjects With Chronic Hepatitis C Virus (HCV) and Inherited Bleeding Disorders [Phase 2]
Phase 2 study evaluating the efficacy and safety of ledipasvir/sofosbuvir fixed-dose combination and sofosbuvir plus ribavirin in adults wit…