Hepatitis C

CLINICAL_TRIALS withdrawal · 2016-12-05

Clinical Trial Update: Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD) [Phase 3]

A Phase 3 trial evaluating Ombitasvir/Paritaprevir/Ritonavir for genotype 1b chronic hepatitis C virus infection in Japanese adults with end…

EMA safety_alert · 2016-12-02

PRAC warns of risk of hepatitis B re-activation with direct-acting antivirals for hepatitis C

The EMA’s Pharmacovigilance Risk Assessment Committee warns that hepatitis B re-activation can occur in patients with past or current hepati…

CLINICAL_TRIALS trial_result · 2016-11-30

Clinical Trial Update: Folinic Acid: Supplementation and Therapy [Phase 3]

The document reports the completion of a Phase 3 trial evaluating folinic acid supplementation and therapy in individuals with HIV infection…

CLINICAL_TRIALS trial_result · 2016-11-30

Clinical Trial Update: Safety and Efficacy Study of Single Doses of TT-034 in Patients With Chronic Hepatitis C [Phase 1, Phase 2]

This clinical trial update documents the completion of a single-dose TT-034 safety and efficacy study in patients with chronic hepatitis C (…

CLINICAL_TRIALS trial_result · 2016-11-30

Clinical Trial Update: Ledipasvir/Sofosbuvir Fixed-Dose Combination on Cerebral Metabolism and Neurocognition in Treatment-Naive and Treatment-Experienced Participants With Chronic Genotype 1 HCV Infection [Phase 2]

Phase 2 trial evaluating a fixed-dose combination of ledipasvir/sofosbuvir for chronic hepatitis C genotype 1, focusing on cerebral metaboli…

CLINICAL_TRIALS trial_result · 2016-11-30

Clinical Trial Update: Evaluation of a Multi-disciplinary Approach for the Treatment of Hepatitis C in IDUs (HI-LO Study) [NA]

This update announces the completion of the HI-LO study, which evaluated a multidisciplinary approach for treating hepatitis C in people who…

CLINICAL_TRIALS trial_result · 2016-11-29

Clinical Trial Update: Interferon Alfa Sensitivity in HIV/HCV Persons Before and After HIV Meds [Phase 4]

Phase 4 trial update evaluating interferon alfa sensitivity in HIV/Hepatitis C–coinfected individuals before and after initiation of HIV the…

CLINICAL_TRIALS trial_result · 2016-11-29

Clinical Trial Update: The Role of FGL2-FcgammaRIIB Inhibitory Pathway in Human Viral Hepatitis

This document describes a completed clinical trial evaluating the role of the FGL2-FcgammaRIIB inhibitory pathway in chronic hepatitis C inf…

CLINICAL_TRIALS trial_result · 2016-11-23

Clinical Trial Update: Short Duration Versus Standard Response-Guided Therapy With Boceprevir Combined With PegIntron and Ribavirin in Previously Untreated Non-Cirrhotic Asian Participants With Chronic HCV Genotype 1 (MK-3034-107) [Phase 3]

Phase 3 trial comparing short-duration versus standard response-guided therapy using boceprevir in combination with pegylated interferon and…

CLINICAL_TRIALS trial_result · 2016-11-23

Clinical Trial Update: Safety, Pharmacokinetics and Pharmacodynamics of Elbasvir (MK-8742) in Hepatitis C Infected Males (MK-8742-002) [Phase 1]

This Phase 1 study reports on the safety, pharmacokinetics, and pharmacodynamics of Elbasvir (MK-8742) in male participants infected with he…

CLINICAL_TRIALS trial_result · 2016-11-23

Clinical Trial Update: Metformin Therapy in HCV Infection [Phase 4]

Phase 4 trial evaluating metformin therapy for chronic hepatitis C virus infection has completed; no results are provided in the snippet.

CLINICAL_TRIALS trial_result · 2016-11-22

Clinical Trial Update: Evaluating Three Grams Daily Valacyclovir in Patients With Chronic Hepatitis C and HSV-2 Infection (Phase I) [Phase 1]

Phase I trial evaluating three grams daily valacyclovir in patients with chronic hepatitis C and HSV-2 infection has completed, with results…

CLINICAL_TRIALS trial_result · 2016-11-21

Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Boceprevir Added to Standard of Care Therapy in Previously Treated Participants With Chronic Hepatitis C Genotype 1 and Cirrhosis (MK-3034-105) [Phase 4]

Phase 4 study evaluating boceprevir added to standard of care in previously treated chronic hepatitis C genotype 1 with cirrhosis; completed…

CLINICAL_TRIALS trial_result · 2016-11-17

Clinical Trial Update: Efficacy and Safety Study of Simeprevir in Combination With Sofosbuvir in Subjects With Chronic Genotype 4 Hepatitis C Virus Infection [Phase 3]

Phase 3 study evaluating the efficacy and safety of combining simeprevir with sofosbuvir in adults with chronic hepatitis C virus infection,…

CLINICAL_TRIALS trial_result · 2016-11-17

Clinical Trial Update: Efficacy and Safety of Grazoprevir (MK-5172), Elbasvir (MK-8742), and Sofosbuvir for Chronic Infection With Hepatitis C Virus Genotypes 1 and 3 (MK-5172-074) [Phase 2]

Phase 2 trial evaluating grazoprevir, elbasvir, and sofosbuvir for chronic hepatitis C infection showing efficacy and safety results.

CLINICAL_TRIALS trial_result · 2016-11-16

Clinical Trial Update: Safety and Efficacy of Albumin Interferon Administered Every 4 Weeks in Genotype 2/3 Hepatitis C Patients [Phase 2]

Phase 2 trial update evaluating the safety and efficacy of albumin interferon given every four weeks in patients with genotype 2/3 chronic h…

CLINICAL_TRIALS trial_result · 2016-11-15

Clinical Trial Update: Comparison of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks With Sofosbuvir and Ribavirin for 12 Weeks in Adults With Chronic Genotype 2 HCV Infection [Phase 3]

Phase 3 trial comparing Sofosbuvir/Velpatasvir fixed-dose combination for 12 weeks vs Sofosbuvir and Ribavirin for 12 weeks in adults with c…

CLINICAL_TRIALS research · 2016-11-15

Clinical Trial Update: Differences in Evoked Intracellular Interferon Signaling Pathways Using Single Cell Phosphoprotein Profiling [Phase 1]

A Phase 1 study in Hepatitis C investigating differences in evoked intracellular interferon signaling pathways using single-cell phosphoprot…

CLINICAL_TRIALS trial_result · 2016-11-11

Clinical Trial Update: An Efficacy and Safety Study of Simeprevir and Sofosbuvir With and Without Ribavirin in Participants With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver Transplant [Phase 2]

A Phase 2 study evaluating the efficacy and safety of simeprevir with sofosbuvir, with or without ribavirin, for recurrent genotype 1 hepati…