Hepatic Encephalopathy
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis [Phase 4]
Phase 4 pharmacokinetic study of apixaban to prevent portal hypertension complications in cirrhosis is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Efficacy and Safety of Lemborexant for Patients With Cirrhosis and Sleep Problems [Phase 2]
Phase 2 trial evaluating the efficacy and safety of lemborexant for sleep problems in patients with liver cirrhosis; the study status is com…
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CLINICAL_TRIALS trial_result · 2026-02-18Clinical Trial Update: The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
The Liver Cirrhosis Cognitive Decline Scale (LiCCoS) is the subject of a recruiting clinical trial investigating cognitive dysfunction in pa…
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy [Phase 2]
Genfit's Phase 2 trial of the investigational medicine VS-01 for hepatic encephalopathy in patients with acute-on-chronic liver failure and …
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis [Phase 3]
A Phase 3 trial evaluating the efficacy and safety of nifuroxazide for hepatic encephalopathy in patients with liver cirrhosis has completed…
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: Deprescribing Proton Pump Inhibitors to Reduce Post-TIPS Hepatic Encephalopathy [Phase 1, Phase 2]
This clinical trial update summarizes completed Phase 1/2 studies evaluating whether deprescribing proton pump inhibitors can reduce hepatic…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) [Phase 1]
A Phase 1 trial assessing intravenous branched-chain amino acids for hepatic encephalopathy in patients with acute-on-chronic liver failure …
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: FMT in Cirrhosis and Hepatic Encephalopathy [Phase 1, Phase 2]
This update reports the completed Phase 1 and Phase 2 trials of fecal microbiota transplantation for cirrhosis and hepatic encephalopathy, w…
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CLINICAL_TRIALS trial_result · 2025-04-03Clinical Trial Update: Metobolomics in the Characterisation of HE
The document reports completion of a metabolomics study aimed at characterizing hepatic encephalopathy in patients with cirrhosis.
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS) [NA]
A completed clinical trial evaluated the efficacy of albumin dialysis using the MARS system to treat hepatic encephalopathy in patients with…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy
A completed clinical trial describes administering lactulose via a balloon rectal tube for severe hepatic encephalopathy.
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Effect of Brief Dietary Intervention on Ammonia Levels [NA]
This completed clinical trial evaluated whether a brief dietary intervention lowers ammonia levels in people with cirrhosis and hepatic ence…
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CLINICAL_TRIALS trial_result · 2024-11-26Clinical Trial Update: Efficacy of L-Ornithine L-Aspartate (LOLA) as an Adjunct to Branched Chain Amino Acids (BCAA) Enriched Solutions on Clinical Outcomes in ICU Patients With Hepatic Encephalopathy [Phase 4]
Phase 4 trial evaluating L-Ornithine L-Aspartate as an adjunct to BCAA-enriched solutions for Hepatic Encephalopathy in ICU patients; the st…
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CLINICAL_TRIALS trial_result · 2024-11-19Clinical Trial Update: TIPS Plus Transvenous Obliteration for Gastric Varices
A completed clinical trial evaluated the combination of transjugular intrahepatic portosystemic shunt (TIPS) with transvenous obliteration f…
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CLINICAL_TRIALS trial_result · 2024-07-26Clinical Trial Update: Speech in Hepatic Encephalopathy (HE)
A clinical trial evaluating a speech-related intervention for hepatic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2024-06-20Clinical Trial Update: A Study of Glyceryl Tri-(4-phenylbutyrate) Administered Orally as a Single Dose, and Twice Daily for Seven Consecutive Days to Subjects With Hepatic Impairment With Cirrhosis and to a Control Group [Phase 1]
A Phase 1 study evaluated the safety and pharmacokinetics of glyceryl tri-(4-phenylbutyrate) given as a single dose and twice-daily dosing f…
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CLINICAL_TRIALS trial_result · 2024-06-17Clinical Trial Update: A Study of MHE in Patients With Liver Diseases
This clinical trial update notes the completion of a study evaluating minimal hepatic encephalopathy in patients with liver diseases, includ…
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CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: VE303 for Treatment of Hepatic Encephalopathy (HE) [Phase 2]
Phase 2 clinical trial results for VE303 in hepatic encephalopathy have been posted after completion of the study. The trial enrolled patien…
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CLINICAL_TRIALS trial_result · 2024-03-06Clinical Trial Update: The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. [NA]
A completed clinical trial (BRAINFOOD) investigating prevention of recurrent hepatic encephalopathy in patients with cirrhosis and ascites; …
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CLINICAL_TRIALS trial_result · 2024-01-09Clinical Trial Update: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy [Phase 4]
Phase 4 trial update on rifaximin in subjects with severe hepatic impairment and hepatic encephalopathy; study terminated with posted result…
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CLINICAL_TRIALS trial_result · 2023-10-17Clinical Trial Update: Efficacy of Lactoferrin as an Adjunct Therapy in Patients With Hepatic Encephalopathy [Phase 2]
Phase 2 clinical trial update evaluating lactoferrin as an adjunct therapy for hepatic encephalopathy.
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CLINICAL_TRIALS trial_result · 2023-09-21Clinical Trial Update: Rifamycin in Minimal Hepatic Encephalopathy [Phase 2]
Phase 2 trial update for rifamycin in minimal hepatic encephalopathy has completed.
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CLINICAL_TRIALS trial_result · 2023-07-13Clinical Trial Update: Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy [Phase 4]
Phase 4 trial update investigating the efficacy of L-Ornithine L-Aspartate and polyethylene glycol in cirrhotic patients with overt hepatic …
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CLINICAL_TRIALS trial_result · 2023-04-19Clinical Trial Update: Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial) [Phase 4]
Phase 4 trial comparing polyethylene glycol versus lactulose for hepatic encephalopathy in cirrhosis patients is ongoing with status unknown…
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CLINICAL_TRIALS trial_result · 2023-04-13Clinical Trial Update: Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial comparing allopurinol to atorvastatin for preventing complications in liver cirrhosis and hepatic encephalo…