Hemophilia with Inhibitors
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CLINICAL_TRIALS trial_result · 2025-12-08Clinical Trial Update: A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors [Phase 3]
A Phase 3 study evaluating Mim8 in adults and adolescents with Hemophilia A, with or without inhibitors, has completed.
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Understanding Treatment Outcomes and Immunologic Mechanisms in Altuviiio Immune Tolerance Induction [Phase 4]
Phase 4 clinical trial update on Altuviiio for immune tolerance induction in Hemophilia A with inhibitors, outlining treatment outcomes and …
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CLINICAL_TRIALS withdrawal · 2025-03-11Clinical Trial Update: A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitors [Phase 2]
A Phase 2 study of SerpinPC in participants with Hemophilia B with inhibitors has been terminated.
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CLINICAL_TRIALS research · 2025-03-07Clinical Trial Update: Assessing Different FVIII Doses and Frequencies in Immune Tolerance Induction (ITI) with ADVATE Among Hemophilia a Boys with Inhibitor (INITIATE Study) [Phase 4]
Phase 4 INITIATE trial evaluating different Factor VIII doses and dosing frequencies for immune tolerance induction with ADVATE in boys with…
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CLINICAL_TRIALS withdrawal · 2024-09-26Clinical Trial Update: Individualizing Hemophilia Bypassing Agent Therapy Utilizing Thromboelastography [NA]
The clinical trial NCT03002480 investigating individualized bypassing agent therapy for hemophilia A with inhibitors using thromboelastograp…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia A
This document reports a completed chart review study assessing immune tolerance induction using rFVIIIFc (Elocta) in patients with Hemophili…
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CLINICAL_TRIALS trial_result · 2024-08-19Clinical Trial Update: An Exploration of the Impact of Emicizumab on the Lives of People With Haemophilia and Inhibitors and Their Families
A completed study examining how emicizumab affects daily life for people with Hemophilia A with inhibitors and their families, with results …
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CLINICAL_TRIALS trial_result · 2024-07-19Clinical Trial Update: SS109 and NovoSeven ® PK / PD Profile, and Preliminary Efficacy and Safety of SS109 on Demand Treatment [Phase 1, Phase 2]
Phase 1/2 clinical trial update reporting PK/PD profiles for SS109 and NovoSeven on-demand use, with preliminary efficacy and safety data in…
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CLINICAL_TRIALS trial_result · 2024-03-20Clinical Trial Update: Pharmacokinetic-guided Dosing of Emicizumab [Phase 4]
Phase 4 clinical trial updating pharmacokinetic-guided dosing of emicizumab in people with Hemophilia A (with and without inhibitors) across…
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CLINICAL_TRIALS trial_result · 2021-10-21Clinical Trial Update: A Pharmacokinetic and Clotting Activity Study of FVIII-PEGLip [Phase 2]
Phase 2 pharmacokinetic and clotting activity study of FVIII-PEGLip for Hemophilia A with inhibitors.
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CLINICAL_TRIALS trial_result · 2021-07-07Clinical Trial Update: A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study) [Phase 4]
Phase 4 study evaluating rFVIIIFc for immune tolerance induction in severe Hemophilia A patients with inhibitors; study completed with poste…
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CLINICAL_TRIALS trial_result · 2021-02-04Clinical Trial Update: Clinical Trial Comparing a Biosimilar Eptacog Alfa With Novoseven, in Patients With Hemophilia With Inhibitors [Phase 3]
Phase 3 clinical trial comparing a biosimilar Eptacog alfa with NovoSeven in patients with hemophilia A or B with inhibitors has completed.
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CLINICAL_TRIALS trial_result · 2020-08-28Clinical Trial Update: A Phase III Study on the Safety, Pharmacokinetics and Efficacy of Coagulation Factor VIIa [Phase 3]
Phase III study assessing safety, pharmacokinetics, and efficacy of coagulation Factor VIIa in hemophilia A and B with inhibitors has comple…
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CLINICAL_TRIALS trial_result · 2020-05-29Clinical Trial Update: INdividualized ITI Based on Fviii(ATE) Protection by VWF [Phase 4]
Phase 4 trial update for individualized ITI based on FVIII protection by von Willebrand factor in Hemophilia A patients with inhibitors; tri…
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CLINICAL_TRIALS trial_result · 2019-08-28Clinical Trial Update: Study of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) for On-demand Treatment of Bleeding Episodes in Patients With Hemophilia A or B With Inhibitors [Phase 2, Phase 3]
Phase 2/3 clinical trial update for recombinant factor VIIa fusion protein (rVIIa-FP, CSL689) evaluating on-demand treatment of bleeding in …
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: Non-Interventional Study of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With Inhibitors
This non-interventional study evaluated on-demand NovoSeven for treating bleeds in patients with hemophilia A or B with inhibitors; the stud…
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CLINICAL_TRIALS trial_result · 2017-02-06Clinical Trial Update: Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitors [Phase 2, Phase 3]
A Phase 2/3 trial evaluating activated prothrombin complex concentrate for preventing bleeds in Hemophilia A patients with inhibitors has co…
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CLINICAL_TRIALS trial_result · 2017-01-18Clinical Trial Update: Impact of Pain on Functional Impairment and Quality of Life in Adults With Hemophilia
A completed clinical trial update examining how pain affects functional impairment and quality of life in adults with hemophilia.
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CLINICAL_TRIALS trial_result · 2017-01-13Clinical Trial Update: Safety and Tolerability of Intravenous Doses of Activated Recombinant Human Factor VII in Healthy Volunteers [Phase 1]
A Phase 1 trial evaluating the safety and tolerability of intravenous doses of activated recombinant human factor VII in healthy volunteers.…
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CLINICAL_TRIALS trial_result · 2017-01-12Clinical Trial Update: Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophilia [Phase 2]
This Phase 2 clinical trial update evaluates the efficacy of NovoSeven for bleeding prophylaxis in people with hemophilia, including those w…
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CLINICAL_TRIALS trial_result · 2016-11-23Clinical Trial Update: Prediction of the Efficacy of Activated Recombinant Human Factor VII in Adult Congenital Haemophilia A or B Patients With Inhibitors by Use of Thromboelastography [Phase 1]
Phase 1 trial evaluating whether thromboelastography can predict the efficacy of activated recombinant Factor VII (NovoSeven) in adults with…
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CLINICAL_TRIALS research · 2015-07-10Clinical Trial Update: To Quantify the Range of Main Psychosocial Factors Affecting Patients and Caregivers in Their Daily Lives
Completed clinical trial evaluating the range of psychosocial factors affecting patients with hemophilia and their caregivers in daily life.
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CLINICAL_TRIALS research · 2013-06-17Clinical Trial Update: Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors
This document updates a clinical trial evaluating whether thrombin generation assay can predict the effectiveness of Factor VIII concentrate…
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CLINICAL_TRIALS research · 2013-04-08Clinical Trial Update: rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors [Phase 2]
Phase 2 clinical trial update on prophylactic use of recombinant activated factor VII (rFVIIa) in children with Hemophilia A with inhibitors…
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CLINICAL_TRIALS trial_result · 2011-12-19Clinical Trial Update: Observational Registry of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With Inhibitors
An observational registry evaluating NovoSeven as on-demand treatment for bleeds in patients with Hemophilia A or B with inhibitors; the stu…