Hemophagocytic Lymphohistiocytosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion [NA]
Clinical trial update from Baylor College of Medicine reports results for haploidentical hematopoietic cell transplantation using TCR alpha/…
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CLINICAL_TRIALS research · 2025-09-08Clinical Trial Update: Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation
A recruiting clinical trial in France aims to develop a diagnosis, prognosis, and therapeutic decision-support tool for autoimmune and infla…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation [Phase 1, Phase 2]
This document provides an update on a phase 1/2 clinical trial evaluating CD34+ stem cell selection for patients receiving allogeneic stem c…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Administration of Donor T Cells With the Caspase-9 Suicide Gene [Phase 1]
A Phase 1 trial evaluating donor T cells engineered with a caspase-9 suicide gene to enable controlled safety in hematologic diseases.
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FDA approval · 2025-06-27FDA Approved: GAMIFANT — Supplemental Application (Swedish Orphan Biovitrum AB (publ))
The FDA approved a supplemental application for GAMIFANT (emapalumab-lzsg) filed by Swedish Orphan Biovitrum AB (publ). The action updates t…
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic Characteristics, and Immunogenicity of Plonmarlimab in Subjects With Rheumatic and Immunological Disease-associated Haemophagocytic Lymphohistiocytosis (HLH) (Also Known as Macrophage Activation Syndrome (MAS)) [Phase 2]
A Phase 2 study evaluating the efficacy, safety, tolerability, pharmacokinetic characteristics, and immunogenicity of plonmarlimab in subjec…
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Prospective Validation of the OHI Index
A prospective trial to validate the OHI Index for HLH-related conditions, with recruitment ongoing at Meir Medical Center.
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Dose-modified Emapalumab and Ruxolitinib (E-Ru) Regimens for Hemophagocytic Lymphohistiocytosis [Phase 2, Phase 3]
This clinical trial update outlines dose-modified regimens combining emapalumab and ruxolitinib (E-Ru) for hemophagocytic lymphohistiocytosi…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: Gut Health in Children With Cancer
A clinical trial update indicates that a study on gut health in children with cancer is currently recruiting, enrolling conditions including…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Emapalumab Efficacy in Children With Primary Hemophagocytic Lymphohistiocytosis
Clinical trial update on the efficacy of emapalumab in children with primary Hemophagocytic Lymphohistiocytosis.
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis a Multi-center, Prospective Study
A multi-center prospective study to establish an early warning screening system for Hemophagocytic lymphohistiocytosis, currently recruiting…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Evaluation of IFNγ and Inflammatory Mediators in Patients With Malignancy-Associated Hemophagocytic Lymphohistiocytosis
A completed clinical trial assessed interferon-gamma and other inflammatory mediators in patients with malignancy-associated hemophagocytic …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Evaluation of IFNγ and Inflammatory Mediators in Patients With Hemophagocytic Lymphohistiocytosis
A completed clinical trial evaluated interferon-gamma and other inflammatory mediators in patients with hemophagocytic lymphohistiocytosis; …
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CLINICAL_TRIALS research · 2024-09-05Clinical Trial Update: Flow Cytometry for the Study of T-Cell Populations in Hemophagocytic Lymphohistiocytosis Associated With Lymphomas
A clinical trial investigating flow cytometry to study T-cell populations in lymphoma-associated hemophagocytic lymphohistiocytosis, current…
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CLINICAL_TRIALS research · 2024-08-05Clinical Trial Update: Modified DEP Regimens for the Treatment of Hemophagocytic Lymphohistiocytosis [Phase 4]
This clinical trial update reports on a Phase 4 study evaluating modified DEP regimens for the treatment of hemophagocytic lymphohistiocytos…
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CLINICAL_TRIALS research · 2024-07-11Clinical Trial Update: A Study on Efficacy and Safety of iNK Cells for CAEBV /EBV-HLH After Allo-HSCT [NA]
This ClinicalTrials.gov entry describes a study evaluating the efficacy and safety of iNK cells for chronic active Epstein-Barr virus infect…
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: Zanubrutinib for HLH [Phase 3]
Phase 3 clinical trial update for zanubrutinib in hemophagocytic lymphohistiocytosis (HLH) has completed.
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CLINICAL_TRIALS trial_result · 2024-03-25Clinical Trial Update: Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases [Phase 1]
Phase 1 safety study of gene-modified donor T cell infusion after stem cell transplantation for non-malignant diseases has been terminated; …
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Study to Assess the Efficacy and Safety of Emapalumab in Primary Haemophagocytic Lymphohistiocytosis [Phase 3]
Phase 3 trial assessing efficacy and safety of emapalumab in primary hemophagocytic lymphohistiocytosis has completed with results posted in…
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CLINICAL_TRIALS trial_result · 2024-01-17Clinical Trial Update: Alemtuzumab or Tocilizumab in Combination With Etoposide and Dexamethasone for the Treatment of Adult Patients With Hemophagocytic Lymphohistiocytosis [Phase 2]
Phase 2 trial evaluating alemtuzumab or tocilizumab in combination with etoposide and dexamethasone for adults with hemophagocytic lymphohis…
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Emapalumab in Adult Patients With HLH [Phase 2, Phase 3]
Phase 2/3 trial evaluating emapalumab in adults with hemophagocytic lymphohistiocytosis was terminated; results posted.
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CLINICAL_TRIALS trial_result · 2023-09-14Clinical Trial Update: GTP Regimen in the Treatment of Refractory/Recurrent HLH [Phase 3]
Phase 3 trial update for the GTP regimen in difficult-to-treat hemophagocytic lymphohistiocytosis (HLH).
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CLINICAL_TRIALS trial_result · 2023-03-20Clinical Trial Update: L-DEP Regimen Combined With PD-1 Antibody as Induction Therapy for Epstein-Barr Virus-positive LA-HLH [Phase 3]
A Phase 3 trial is evaluating induction therapy with L-DEP regimen plus a PD-1 antibody for Epstein-Barr Virus-positive hemophagocytic lymph…
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CLINICAL_TRIALS trial_result · 2022-10-06Clinical Trial Update: Cytokine Guided Risk Stratification and Treatment in Pediatric Hemophagocytic Lymphohistiocytosis [Phase 4]
A Phase 4 clinical trial evaluating cytokine-guided risk stratification and treatment for pediatric hemophagocytic lymphohistiocytosis.
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CLINICAL_TRIALS trial_result · 2022-06-28Clinical Trial Update: A Study for Long-term Follow-up of Hemophagocytic Lymphohistiocytosis (HLH) Participants Who Received Treatment With Emapalumab (NI-0501), an Anti-interferon Gamma Monoclonal Antibody [Phase 2, Phase 3]
Long-term follow-up study of HLH patients treated with emapalumab (anti-IFNγ) across Phase 2/Phase 3 completed with posted results in 2022.