Heart Failure
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CLINICAL_TRIALS withdrawal · 2016-04-20Clinical Trial Update: High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure [Phase 4]
A Phase 4 trial evaluating high-dose spironolactone (Aldactone) for diuretic-resistant heart failure has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-04-19Clinical Trial Update: The Congestive Heart Failure Adherence Redesign Trial [Phase 3]
Phase 3 clinical trial update for the Congestive Heart Failure Adherence Redesign Trial; the study status is completed.
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CLINICAL_TRIALS safety_alert · 2016-04-19Clinical Trial Update: Incretin-based Drugs and the Risk of Heart Failure
A CNODES observational study update examines whether incretin-based therapies for type 2 diabetes influence the risk of heart failure.
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CLINICAL_TRIALS trial_result · 2016-04-19Clinical Trial Update: DF4 Master Study (Safety and Efficacy Study)
The DF4 Master Study, Biotronik's safety-and-efficacy trial, has completed and released results. The study evaluated outcomes in patients wi…
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CLINICAL_TRIALS trial_result · 2016-04-19Clinical Trial Update: Efficacy of a Disease Management Program in Very Old Patients With Heart Failure [NA]
A completed clinical trial evaluating the efficacy of a disease management program in very old patients with heart failure. The study appear…
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CLINICAL_TRIALS trial_result · 2016-04-19Clinical Trial Update: Evaluation of the Samsung LABGEO IVD-A20 CHF Test in a Point-of-Care Setting
A study evaluating the Samsung LABGEO IVD-A20 point-of-care test for congestive heart failure has been terminated.
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CLINICAL_TRIALS trial_result · 2016-04-15Clinical Trial Update: Studies of Left Ventricular Dysfunction (SOLVD) [Phase 3]
The SOLVD studies (Studies of Left Ventricular Dysfunction) Phase 3 program has completed, evaluating therapies for left ventricular dysfunc…
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CLINICAL_TRIALS trial_result · 2016-04-15Clinical Trial Update: Trial of an Internet-based Platform for Monitoring Heart Failure Patients [NA]
A trial evaluating an internet-based platform for monitoring heart failure patients has been terminated. No efficacy or safety data are prov…
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) [Phase 3]
This document reports the completion of the Phase 3 ESCAPE trial. It evaluates the effectiveness of pulmonary artery catheterization in cong…
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CLINICAL_TRIALS research · 2016-04-14Clinical Trial Update: Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)
NHLBI-sponsored pediatric study on pulmonary and cardiovascular complications of vertically transmitted HIV infection has completed.
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Honolulu Heart Program
Update on the Honolulu Heart Program, a completed clinical trial focused on cardiovascular diseases and related conditions.
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Atherosclerosis Risk in Communities (ARIC)
ARIC is a long-term NHLBI-sponsored observational study focused on atherosclerosis and cardiovascular disease. This update notes that the st…
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CLINICAL_TRIALS trial_result · 2016-04-14Clinical Trial Update: Beta-Blocker Evaluation in Survival Trial (BEST) [Phase 3]
Phase 3 BEST trial evaluating a beta-blocker for survival in cardiovascular disease has completed.
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CLINICAL_TRIALS research · 2016-04-14Clinical Trial Update: Framingham Heart Study
This entry provides a status update on the Framingham Heart Study sponsored by NHLBI, indicating the study status is COMPLETED and focusing …
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CLINICAL_TRIALS trial_result · 2016-04-13Clinical Trial Update: Efficiency Study of Triple-Site Cardiac Resynchronization in Patients With Heart Failure [Phase 2, Phase 3]
A Phase 2/3 trial evaluating triple-site cardiac resynchronization therapy in patients with heart failure has completed.
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CLINICAL_TRIALS withdrawal · 2016-04-13Clinical Trial Update: Cardiac REgistry of Celution Device for the Processing of Adipose-derived Regenerative Cells
The Celution device cardiac registry trial for processing adipose-derived regenerative cells in heart failure and coronary artery disease ha…
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CLINICAL_TRIALS trial_result · 2016-04-13Clinical Trial Update: Right Apical Versus Septal Pacing Trial [NA]
Clinical trial update comparing right apical versus septal pacing for heart block and heart failure; the current status of the trial is unkn…
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FDA approval · 2016-04-12FDA Approved: ENALAPRIL MALEATE — Supplemental Application (ScieGen Pharmaceuticals, Inc.)
The FDA approved a supplemental application for enalapril maleate from ScieGen Pharmaceuticals, Inc. (ANDA 075178).
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CLINICAL_TRIALS research · 2016-04-11Clinical Trial Update: Characterization of Adipose Derived Regenerative Cells (ADRCs) From Patients With Chronic Heart Disease
This clinical trial update reports on the characterization of adipose-derived regenerative cells (ADRCs) isolated from patients with chronic…
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CLINICAL_TRIALS research · 2016-04-11Clinical Trial Update: Peripheral Metabolic Function in Chronic Heart Failure Patients [NA]
This document reports a clinical trial update on peripheral metabolic function in patients with chronic heart failure. No phase, status, or …
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CLINICAL_TRIALS research · 2016-04-11Clinical Trial Update: Mathematical Models Derived Indices for the Selection and Planning of a Specific Optimal Treatment to the Patient in Heart Failure [NA]
This document reports a clinical trial update exploring mathematical models to derive indices that guide selection and planning of patient-s…
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CLINICAL_TRIALS trial_result · 2016-04-08Clinical Trial Update: Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum
This clinical trial update announces the completion of a study evaluating transvenous left ventricular septum pacing via the interventricula…
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CLINICAL_TRIALS trial_result · 2016-04-07Clinical Trial Update: Self-management and Cognitive Function in Adults With Heart Failure
This clinical trial update indicates a self-management intervention for adults with heart failure has completed. No pharmacological interven…
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CLINICAL_TRIALS trial_result · 2016-04-06Clinical Trial Update: Metal-on-metal Hip Prostheses: Do They Have Systemic Effects?
A completed clinical trial evaluates whether metal-on-metal hip prostheses have systemic effects, including potential cardiovascular implica…
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CLINICAL_TRIALS trial_result · 2016-04-06Clinical Trial Update: Cardiac Assessment of Patients With Hip Implants
A completed clinical trial assessing cardiac health in patients with hip implants. The study NCT02331264, sponsored by the Royal National Or…