Heart Failure with Preserved Ejection Fraction
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CLINICAL_TRIALS other · 2026-03-13Clinical Trial Update: Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF [NA]
This clinical trial update indicates that a study comparing left bundle branch pacing versus right ventricular pacing in patients with prese…
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)
A comparative effectiveness trial comparing oral semaglutide to sitagliptin in individuals with Type 2 diabetes mellitus and heart failure w…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease [NA]
Clinical trial update for a randomized study evaluating the Enhancor System, a pulmonary artery denervation device, in patients with combine…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy [Phase 2]
A Phase 2 clinical trial sponsored by Novo Nordisk is evaluating different doses of CDR132L versus placebo for heart failure with preserved …
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: The ENCHANTMENT HIV Study [Phase 2]
The ENCHANTMENT HIV Study, a Phase 2 trial, has completed (status: COMPLETED) and investigates HIV/AIDS with comorbid heart failure with pre…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
A clinical trial is evaluating an AI-based monitoring system for chronic heart failure using wearable and mini-invasive devices. The study i…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Prospective Evaluation of AI-ECG for SHD Detection
Imperial College London is conducting a prospective study to evaluate an AI-enabled ECG for detecting structural heart disease; the trial is…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Exercise Intolerance in Heart Failure
A clinical trial from Johns Hopkins is evaluating exercise intolerance in heart failure with preserved ejection fraction (HFpEF) and is curr…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 clinical trial evaluating the cardiac and metabolic effects of semaglutide in heart failure with preserved ejection fraction (HFpEF)…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Acute Effect of Nurse-assessed Remote Ischemic Preconditioning on Improving Vascular Parameters in Patients With Suspected Heart Failure With Preserved Ejection Fraction [NA]
Clinical trial update on a study evaluating whether nurse-assessed remote ischemic preconditioning improves vascular parameters in patients …
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
A real-time heart failure monitoring clinical trial across Yale New Haven Health System is currently recruiting participants, focusing on he…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Investigation on the Impact of Finerenone on Myocardial Remodeling in Patients With Diabetic Kidney Disease and Heart Failure [Phase 4]
Phase 4 clinical trial investigating the effect of finerenone on myocardial remodeling in patients with diabetic kidney disease and heart fa…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD
This update notes that the CS Reducer trial for symptomatic heart failure with preserved ejection fraction and coronary microvascular dysfun…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF) [Phase 4]
A Phase 4 clinical trial evaluating deprescribing beta-blockers in elderly patients with heart failure with preserved ejection fraction (HFp…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation [Phase 2]
Phase 2 trial evaluating whether LoDoCo improves exercise capacity in patients with heart failure with preserved ejection fraction and infla…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Testing the CHAT Program for Patients With Heart Failure [NA]
This clinical trial update indicates that the CHAT Program for patients with heart failure with preserved ejection fraction is currently enr…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction [Phase 4]
Phase 4 clinical trial update evaluating a neprilysin inhibitor to reduce myocardial fibrosis in heart failure with preserved ejection fract…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction
A clinical trial update on data-driven phenotyping in heart failure with preserved ejection fraction (HFpEF); the study is currently not yet…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF) [Phase 4]
A Phase 4 clinical trial evaluating intravenous iron repletion to improve exercise tolerance mechanisms in patients with iron deficiency and…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC) [Phase 2]
A Phase 2 trial evaluating exercise plus activin inhibition to modulate inflammation effects in heart failure with preserved ejection fracti…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF [Phase 3]
Phase 3 trial of levosimendan to improve exercise limitation in patients with pulmonary hypertension due to heart failure with preserved eje…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEF [Phase 4]
A Phase 4 clinical trial is evaluating the effect of sacubitril/valsartan on heart function in chronic hemodialysis patients with heart fail…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients. [NA]
This clinical trial is investigating ultrasound contrast agents as noninvasive pressure sensors to estimate cardiac pressures, validated aga…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication [NA]
This clinical trial update reports a study recruiting patients to compare ablation versus medical therapy for treating atrial fibrillation i…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction
This clinical trial update outlines a real-world study to evaluate the effectiveness and safety of Jardiance (empagliflozin) in Chinese pati…