Heart Failure with Preserved Ejection Fraction
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy [NA]
An upcoming clinical trial is evaluating percutaneous coronary intervention with guideline-directed medical therapy for patients with heart …
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Intracranial Pressure and a Potential Vicious Circle of Atrial Fibrillation in HFpEF
The completed trial update highlights associations among intracranial pressure, optic nerve sheath diameter, venous congestion, and atrial f…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Northwestern University-led clinical trial investigating myocardial mechanisms in heart failure with preserved ejection fraction is currentl…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) [Phase 1]
Phase 1 trial evaluating the safety, tolerability, and biomarker signals of VS-041 in participants with heart failure with preserved ejectio…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF [NA]
This clinical trial update describes PREACTIVE, a study evaluating a preconditioning exercise program to improve symptoms and quality of lif…
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure. [NA]
Trial update reporting completion of a study evaluating the effectiveness of a cardiac rehabilitation program in elderly patients with heart…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan [EARLY_Phase 1]
This early-phase trial plan explores the cardiovascular benefits of SGLT2 inhibitors and ketone strategies in people with type 2 diabetes an…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) [Phase 4]
Phase 4 trial evaluating concomitant administration of macitentan and dapagliflozin in patients with heart failure with mid-range and preser…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
This registry entry describes a German clinical study to determine how common unrecognized heart failure is among at-risk urban patients usi…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? [Phase 4]
An update on a Phase 4 trial evaluating pharmacological optimization to prevent heart failure, including consideration of sex differences; r…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: ELEVATE-HFpEF Clinical Study [NA]
Clinical trial update for ELEVATE-HFpEF studying a therapy for heart failure with preserved ejection fraction; the study is currently recrui…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study) [Phase 2]
Phase 2 clinical trial APEX is evaluating TX000045 for pulmonary hypertension secondary to heart failure with preserved ejection fraction an…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Ablation Versus Medical Management of Atrial Fibrillation in HFpEF [NA]
The clinical trial evaluating ablation versus medical management for atrial fibrillation in patients with heart failure with preserved eject…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: PBMC as Biomarkers of Diabetic Cardiomyopathy
A clinical trial is evaluating peripheral blood mononuclear cells as biomarkers for diabetic cardiomyopathy and related heart failure condit…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching [NA]
This update covers a clinical trial (BOOST) evaluating a blended onsite and offsite structured exercise training and coaching program for he…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
A UT Southwestern Medical Center study is investigating how adiposity influences muscle and microvascular function in patients with heart fa…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program
This clinical trial update reports the completion of a national telemonitoring program evaluating the use of SGLT2 inhibitors in heart failu…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Precision Rehabilitation for Veterans With (HFpEF)
This update describes a recruiting clinical trial studying precision rehabilitation for veterans with heart failure with preserved ejection …
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: CAPTURE-HFpEF: National Study of Identification and Phenotyping of Heart Failure With Preserved Ejection Fraction
This is a protocol for the CAPTURE-HFpEF national study to identify and phenotype heart failure with preserved ejection fraction. Recruitmen…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Purinergic Signaling and the Postmenopausal Heart
A clinical trial evaluating purinergic signaling in postmenopausal heart function is currently recruiting. The study targets heart failure w…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure [NA]
This clinical trial update indicates that enrollment is ongoing by invitation for evaluating the Coronary Sinus Reducer device to manage sym…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Cardiac Rehab Effects in HFpEF [NA]
Clinical trial update on the effects of cardiac rehabilitation in patients with heart failure with preserved ejection fraction, noting the s…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: RESPONDER-HF Trial [NA]
The RESPONDER-HF trial by Corvia Medical is currently ACTIVE_NOT_RECRUITING, evaluating an interatrial shunt device for heart failure (inclu…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: The Use of Advanced Imaging in HFpEF
This clinical trial registry entry indicates that a study evaluating advanced imaging in heart failure with preserved ejection fraction is c…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF [NA]
This clinical trial update indicates ongoing recruitment for a study evaluating endovascular ablation of the right greater splanchnic nerve …