Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy [Phase 2]
Phase II, single-center study assessing immune maintenance therapy after neoadjuvant immunotherapy plus chemotherapy in locally advanced hea…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating ALE.P02 as monotherapy in adults with CLDN1+ solid tumors, including squamous cell carcinomas of th…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCC [Phase 3]
This Phase 3 trial compares re-radiochemotherapy plus pembrolizumab to immuno(chemo)therapy in locoregionally recurrent PD-L1-positive head …
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01 [Phase 2]
Phase 2 clinical trial update for a novel treatment combination in head and neck squamous cell carcinoma; study status is active but not cur…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Comparative Study of Efficacy and Safety of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma [Phase 3]
Phase 3 trial comparing RPH-002 with Erbitux (cetuximab) for unresectable metastatic or recurrent head and neck squamous cell carcinoma, foc…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: CIML NK Cell in Head & Neck Cancer [Phase 1]
A Phase 1 trial evaluating CIML NK cells in head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Phase I Comparative Study of Pharmacokinetics, Safety, and Efficacy of RPH-002 and Erbitux® in Unresectable Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma [Phase 1]
A Phase I comparative study evaluating pharmacokinetics, safety, and preliminary efficacy of RPH-002 versus cetuximab (Erbitux) in unresecta…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC [Phase 2]
Phase 2 trial evaluating PD-L1 t-haNK with NAI IL-15sa and cetuximab for recurrent/metastatic head and neck squamous cell carcinoma is curre…
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CLINICAL_TRIALS withdrawal · 2026-02-27Clinical Trial Update: Predicting Immunotherapy Efficacy in Head and Neck Squamous Cell Cancer
A clinical trial investigating biomarkers to predict immunotherapy efficacy in head and neck squamous cell carcinoma has been withdrawn.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial studying decreasing radiation therapy and chemotherapy in head and neck cancer is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers [Phase 2]
Phase 2 study of E7-targeted TCR-T cell immunotherapy for HPV-associated cancers is currently recruiting. The sponsor is Christian Hinrichs …
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Local Injection Methylene Blue Combined With Radiation in HNSCC Patients [EARLY_Phase 1]
An early-phase clinical trial is evaluating local injection methylene blue in combination with radiation therapy for head and neck cancer, i…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell Carcinoma [Phase 1]
Phase 1 study evaluating the safety and tolerability of the radiotracer [18F]NOTA-ABY030 in indeterminate primary or metastatic head and nec…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 3]
Phase 3 clinical trial evaluating camrelizumab combined with an EGFR monoclonal antibody or chemotherapy as perioperative treatment for loca…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC [Phase 2]
Phase 2 clinical trial update evaluating molecular residual disease interception in locoregionally advanced HPV+ and HPV- head and neck squa…
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CLINICAL_TRIALS other · 2026-02-25Clinical Trial Update: A Phase 1, Multicenter Imaging Study of LNTH-2403 in Participants With Locally Advanced or Metastatic Solid Tumors. [Phase 1]
Phase 1 multicenter imaging trial update for LNTH-2403 in locally advanced or metastatic solid tumors; currently NOT_YET_RECRUITING.
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-γ Expression and CTM Correlation With DS-SACA Chip
Clinical trial update on a microfluidic-based liquid biopsy platform to prognosticate recurrent/metastatic head and neck cancers using NK ce…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Microbiome in Head and Neck Squamous Cell Carcinoma
This ClinicalTrials.gov update describes an ongoing study at University of Colorado, Denver examining the role of the microbiome in head and…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: MicroRNA Markers in Head and Neck Cancers
Ongoing clinical trial at the University of Colorado investigates microRNA markers in head and neck squamous cell carcinoma. The study is cu…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC [Phase 1, Phase 2]
Ongoing Phase 1/2 clinical trial evaluating autologous CSPG4-targeted CAR-T cells for relapsed or refractory head and neck squamous cell car…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents [Phase 1, Phase 2]
Clinical trial update on ascending doses of ceralasertib in combination with chemotherapy or other anti-cancer agents in advanced solid mali…
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC [Phase 2]
This is a Phase II neoadjuvant trial evaluating cetuximab in combination with cemiplimab for patients undergoing surgery for head and neck s…
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CLINICAL_TRIALS trial_result · 2026-02-19Clinical Trial Update: INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy [Phase 2]
A Phase II study evaluating involved nodal radiation therapy (INRT-AIR) for head and neck squamous cell carcinoma has completed and posted r…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination [Phase 1, Phase 2]
Phase 1/2 trial update evaluating MCLA-129, a bispecific anti-EGFR and anti-c-MET antibody, in advanced non-small cell lung cancer and other…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: 177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors [EARLY_Phase 1]
Early-phase clinical trial investigating a radiolabeled anti-PD-L1 single-domain antibody (177Lu-anti-PD-L1 sdAb) in metastatic solid tumors…