Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Impact of Patient-Reported Outcomes for Symptom Monitoring in Patients Followed for Head and Neck Squamous Cell Carcinoma (HNSCC) [NA]
This entry describes an ongoing clinical trial evaluating the impact of patient-reported outcomes for symptom monitoring in patients with he…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma
A clinical trial update describing validation of molecular diagnostic assays that detect cancer biomarkers in blood and primary tumors. The …
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors [Phase 1]
First-in-human Phase 1 study of JAB-3312 in adults with advanced solid tumors has been completed, evaluating multiple tumor indications.
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients. [Phase 2]
A Phase 2 trial in operable Head and Neck Squamous Cell Carcinoma compares low-dose radiotherapy plus targeted therapy and immunotherapy ver…
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma [Phase 1]
This is a Phase 1 trial evaluating low-dose radiotherapy plus tislelizumab in combination with afatinib as neoadjuvant therapy for surgicall…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
An early-phase clinical trial compares 89Zr-labeled panitumumab with FDG-PET imaging to help identify head and neck squamous cell carcinoma …
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the combination of tipifarnib and alpelisib in adults with recurrent or metastatic head and neck squam…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 2]
A Phase 2 clinical trial evaluating carboplatin, paclitaxel, and cetuximab for recurrent/metastatic head and neck squamous cell carcinoma af…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Thermotherapy in Addition to SOC Palliative Radiotherapy [NA]
A clinical trial update indicating recruitment for a study evaluating thermotherapy added to standard of care palliative radiotherapy in pat…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: (89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma [Phase 1]
Phase 1 clinical trial evaluating 89Zr-labeled panitumumab with PET/CT for diagnosing metastases in head and neck squamous cell carcinoma; c…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients [Phase 2]
Ongoing Phase 2 clinical trial evaluating pembrolizumab in combination with metformin for metastatic head and neck squamous cell carcinoma; …
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CLINICAL_TRIALS withdrawal · 2025-12-19Clinical Trial Update: Time Restricted Eating (TRE) in Metastatic Head and Neck Squamous Cell Cancer (mHNSCC) or Unresectable or Metastatic Renal Cell Carcinoma (RCC) [NA]
A clinical trial investigating time-restricted eating in metastatic head and neck squamous cell carcinoma and unresectable or metastatic ren…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca [Phase 2]
Phase 2 neoadjuvant trial combining targeting of myeloid cell populations with Nivolumab in head and neck squamous cell carcinoma is current…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study. [Phase 4]
A Phase 4 window-of-opportunity pilot trial evaluating methylnatrexone in resectable head and neck squamous cell carcinoma is currently recr…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer [Phase 2]
This clinical trial update describes a Phase 2 study of sorafenib in combination with carboplatin and paclitaxel for metastatic or recurrent…
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CLINICAL_TRIALS trial_result · 2025-12-17Clinical Trial Update: Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial update comparing PCC (paclitaxel, carboplatin, cetuximab) with C-TPF (cetuximab, docetaxel, cisplatin, fluorouracil) in previo…
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CLINICAL_TRIALS withdrawal · 2025-12-17Clinical Trial Update: Phase I/II Open Label Study Evaluating the Safety and Efficacy of Combining STAT3 Inhibition (TTI-101) With Anti-PD-1 Therapy (Pembrolizumab) in Patients With Recurrent or Metastatic (RM) Head and Neck Squamous Cell Carcinoma (HNSCC) [Phase 1, Phase 2]
A Phase I/II open-label trial of combining the STAT3 inhibitor TTI-101 with pembrolizumab for recurrent or metastatic head and neck squamous…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors [Phase 1]
A Phase 1 study of SGN-B6A in Chinese participants with advanced solid tumors has completed, reporting safety and preliminary activity acros…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers [Phase 2]
Phase 2 trial evaluating nivolumab for reversal of squamous dysplasia in high-risk current and former smokers; results have been posted.
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: ABY-029 Head & Neck Trial [Phase 1]
Phase 1 trial update for ABY-029 in head and neck squamous cell carcinoma. The study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma
Clinical trial update on tumor-informed ctDNA testing for minimal residual disease after treatment in head and neck squamous cell carcinoma …
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CLINICAL_TRIALS trial_result · 2025-12-11Clinical Trial Update: Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors [Phase 3]
Phase 3 trial evaluating the duration of PD-1/PD-L1 inhibitor therapy in advanced solid tumors; the study has completed.
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CLINICAL_TRIALS trial_result · 2025-12-11Clinical Trial Update: Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC [Phase 2]
This clinical trial update reports the completion of a Phase 2 study evaluating the combination of eftilagimod alpha and pembrolizumab in pa…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: A Study of MT-4561 in Patients With Various Advanced Solid Tumors [Phase 1, Phase 2]
This trial update reports that MT-4561 is being studied in multiple advanced solid tumors across Phase 1/Phase 2 and is currently recruiting…
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CLINICAL_TRIALS other · 2025-12-11Clinical Trial Update: Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy [NA]
This entry reports a multi-site clinical trial comparing navigation to treatment as usual to improve timely initiation of adjuvant therapy i…