Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations [Phase 1, Phase 2]
Phase 1/2 trial of TER-2013 in solid tumors harboring AKT/PI3K/PTEN alterations is currently recruiting to assess safety and preliminary eff…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery [Phase 2]
A Phase 2 clinical trial is assessing the addition of cisplatin to postoperative radiation therapy for stage III-IV squamous cell carcinoma …
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC) [Phase 2]
Phase 2 trial evaluating the effect of postbiotics on microbiota and systemic immunomodulation of pembrolizumab as first-line therapy in rec…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC) [Phase 2]
Phase 2 trial exploring neoadjuvant XL-092 (zanzalintinib) with pembrolizumab (Keytruda) for surgically resectable, HPV-negative oral cavity…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Study of CHS-114 in Participants With Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating CHS-114 in participants with advanced solid tumors, including head and neck squamous cell carcinoma; currently recr…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors [Phase 1]
This update reports on a Phase 1 trial testing the combination of sonidegib and pembrolizumab in patients with various advanced solid tumors…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer [Phase 2]
A Phase 2 clinical trial evaluating cetuximab after immunotherapy for head and neck squamous cell carcinoma (including recurrent and metasta…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy [Phase 3]
A Phase 3 global study evaluating Volrustomig (MEDI5752) in participants with unresected locally advanced head and neck squamous cell carcin…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating FID-007 in combination with cetuximab for advanced head and neck squamous cell carcinoma is currently ac…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Development of Patient Derived Xenografts (PDXs) and Analysis of Tyrosine Kinase Receptor Expression in Patients With Squamous Cell Head and Neck Cancer (HNSCC) to Study Resistance Mechanisms Induced by Standard Therapy
This clinical trial update describes developing patient-derived xenografts from head and neck squamous cell carcinoma patients and analyzing…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors [Phase 1]
A Phase 1 study evaluating Zanzalintinib in combination with immuno-oncology agents in patients with various solid tumors; recruitment is on…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors [Phase 1, Phase 2]
A Mayo Clinic-sponsored phase 1/2 trial evaluating a personalized neoantigen peptide-based vaccine in combination with pembrolizumab for adv…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Efficacy and Safety Evaluation of VS-101 in Combination With Chemoradiotherapy in Patients With Head and Neck Cancer [Phase 2]
Phase 2 clinical trial evaluating VS-101 in combination with chemoradiotherapy for head and neck squamous cell carcinoma is currently recrui…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: DCSZ11 in Combination With Standard Therapy in Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 trial evaluating DCSZ11 in combination with standard therapy for advanced or metastatic solid tumors is currently recruiting. Th…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: A Study Testing Emactinib Sulfate With Chemotherapy and Immunotherapy Before Surgery for Advanced Head and Neck Cancer [Phase 2]
This entry reports a Phase 2 clinical trial evaluating emactinib sulfate in combination with chemotherapy and immunotherapy before surgery f…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 3]
Phase 3 trial evaluating combining radiation therapy with immunotherapy for metastatic and stage IV squamous cell carcinomas of the head and…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: A Phase II Clinical Study to Evaluate HLX43 in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase II clinical trial evaluating HLX43 for recurrent or metastatic head and neck squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: HN-QUEST: A Study of Head and Neck Imaging Biomarkers [NA]
The HN-QUEST study investigates imaging biomarkers for head and neck squamous cell carcinoma. The trial is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Evaluating 111In Panitumumab for Nodal Staging in Head and Neck Cancer [Phase 1]
Phase 1 clinical trial evaluating indium-111 labeled panitumumab for nodal staging in head and neck squamous cell carcinoma; the study is cu…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer [Phase 1]
Phase 1 trial evaluating TMV vaccine therapy alone and with pembrolizumab for recurrent/metastatic head and neck squamous cell carcinoma; cu…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment [Phase 2]
This clinical trial update describes a Phase 2 study comparing two immunotherapy options in patients with HPV-positive head and neck cancer …
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer [Phase 1]
Phase 1 dosing study evaluating radiation in combination with tislelizumab and pamiparib in previously treated head and neck cancer is curre…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CT
This clinical trial is evaluating whether early response to first-line anti-PD-1 monotherapy in recurrent/metastatic head and neck squamous …
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer [NA]
This clinical trial update describes a Phase II study of daily adaptive radiotherapy to spare the submandibular gland during treatment of he…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca [Phase 2]
Phase 2 clinical trial update for cemiplimab, with or without chemotherapy, followed by biomarker-guided treatment in HPV-related head and n…