Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2022-05-10Clinical Trial Update: MAP-guided Preemptive Therapy of aGvHD [Phase 2]
A Phase 2 clinical trial evaluating MAP-guided preemptive therapy for acute graft-versus-host disease (GVHD) following stem cell transplanta…
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CLINICAL_TRIALS trial_result · 2022-05-09Clinical Trial Update: Treatment of Chronic Graft Versus Host Disease With Arsenic Trioxide [Phase 2]
Phase 2 trial investigating arsenic trioxide for treatment of chronic graft-versus-host disease has completed with posted results.
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CLINICAL_TRIALS trial_result · 2022-04-27Clinical Trial Update: Efficacy and Safety of Low-dose Ibrutinib and Itraconazole in Chronic Graft Versus Host Disease [Phase 2]
Phase 2 trial evaluating low-dose ibTrutinib and itraconazole for efficacy and safety in chronic graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2022-04-20Clinical Trial Update: MTX and Steroid for III-IV aGVHD Treatment [Phase 2]
Phase 2 clinical trial update investigating methotrexate and steroid for treatment of acute graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2022-04-15Clinical Trial Update: A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3) [Phase 3]
Phase 3 REACH3 trial comparing ruxolitinib to best available therapy for steroid-refractory chronic graft-versus-host disease after allogene…
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CLINICAL_TRIALS trial_result · 2022-03-17Clinical Trial Update: A Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Participants Who Have Failed to Respond to Steroid Treatment for Acute Graft-Versus-Host Disease (aGVHD) [Phase 3]
Phase 3 trial investigating remestemcel-L (ex vivo cultured mesenchymal stromal cells) for pediatric steroid-refractory acute GVHD; study co…
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CLINICAL_TRIALS trial_result · 2022-03-16Clinical Trial Update: Safety Follow-up of Treatment With Remestemcel-L in Pediatric Participants Who Have Failed to Respond to Steroid Treatment for Acute GVHD [Phase 3]
Phase 3 safety follow-up study of remestemcel-L in pediatric patients with acute graft-versus-host disease that failed to respond to steroid…
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CLINICAL_TRIALS trial_result · 2022-03-11Clinical Trial Update: A Prospective, Open Label, Dose-escalation, SAD/MAD, Multicenter, 24weeks, Phase I/IIa Clinical Trial to Evaluate the Safety, Tolerability and Pharmacodynamics of Investigational Product (VM-001) in Patients With Graft-versus-host Disease(GvHD) [Phase 1, Phase 2]
A phase I/IIa open-label trial evaluating safety, tolerability, and pharmacodynamics of VM-001 in patients with graft-versus-host disease (G…
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CLINICAL_TRIALS trial_result · 2022-03-02Clinical Trial Update: In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and Sirolimus [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating in-vivo regulatory T cell enhancement using cyclophosphamide and sirolimus for graft-versus-host disea…
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CLINICAL_TRIALS trial_result · 2022-02-22Clinical Trial Update: Efficacy and Safety Study of 4-Day ATG Regimen for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT [Phase 2]
Phase 2 trial update evaluating a 4-day ATG regimen for prophylaxis of acute and chronic GVHD after matched sibling donor peripheral blood s…
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CLINICAL_TRIALS trial_result · 2022-02-10Clinical Trial Update: Efficacy and Safety of Adult Human Mesenchymal Stem Cells to Treat Steroid Refractory Acute Graft Versus Host Disease (GVHD) [Phase 3]
Phase 3 trial update evaluating adult human mesenchymal stem cells for efficacy and safety in steroid-refractory acute graft-versus-host dis…
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CLINICAL_TRIALS trial_result · 2022-02-10Clinical Trial Update: Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease [Phase 2]
Phase 2 trial assessing dexamethasone to prevent oral chronic graft-versus-host disease; study completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-01-31Clinical Trial Update: Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD) [Phase 2]
Phase 2 clinical trial update evaluating adult human mesenchymal stem cells for treating acute graft-versus-host disease (GVHD) has complete…
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CLINICAL_TRIALS trial_result · 2022-01-19Clinical Trial Update: Efficacy and Safety of Prochymal® Infusion in Combination With Corticosteroids for the Treatment of Newly Diagnosed Acute Graft Versus Host Disease (GVHD) [Phase 3]
Phase 3 trial update evaluating Prochymal infusion with corticosteroids for newly diagnosed acute graft-versus-host disease; study completed…
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CLINICAL_TRIALS trial_result · 2022-01-11Clinical Trial Update: Comparison of PT-Cy at a Dose of 25 mg/kg/Day and PT-Cy at a Dose of 50 mg/kg/Day in GVHD Prophylaxis [Phase 3]
Phase 3 trial comparing two doses of post-transplant cyclophosphamide (PT-Cy) for graft-versus-host disease prophylaxis; status not disclose…
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CLINICAL_TRIALS trial_result · 2021-12-14Clinical Trial Update: Low Dose Ruxolitinib in Combination With Methylprednisolone [Phase 1, Phase 2]
Clinical trial update for low-dose ruxolitinib combined with methylprednisolone in Phase 1/2 for acute graft-versus-host disease and stem ce…
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate/Severe Chronic Graft-versus-host Disease [Phase 1, Phase 2]
Early-phase trial investigating umbilical cord mesenchymal stem cells for moderate to severe chronic graft-versus-host disease. Phase 1/2 st…
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CLINICAL_TRIALS trial_result · 2021-12-01Clinical Trial Update: Study of Chidamide for Steroid-resistant/Steroid-dependent Severe cGVHD [Phase 1, Phase 2]
Clinical trial update for chidamide in steroid-resistant or steroid-dependent severe chronic graft-versus-host disease (cGVHD) spanning Phas…
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CLINICAL_TRIALS trial_result · 2021-09-23Clinical Trial Update: Sirolimus & Mycophenolate Mofetil as GVHD Prophylaxis in Myeloablative, Matched Related Donor HCT [Phase 2]
Phase 2 trial evaluating sirolimus and mycophenolate mofetil for GVHD prophylaxis in myeloablative matched related donor hematopoietic cell …
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CLINICAL_TRIALS trial_result · 2021-09-16Clinical Trial Update: MTX and Steroid for aGVHD Treatment [Phase 2]
Phase 2 clinical trial update evaluating methotrexate and steroids for acute graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2021-09-14Clinical Trial Update: GVHD Prophylaxis With Methotrexate in Haploidentical HCT Using Posttransplant Cyclophosphamide [Phase 1, Phase 2]
Clinical trial evaluating methotrexate for GVHD prophylaxis in haploidentical hematopoietic cell transplantation with post-transplant cyclop…
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CLINICAL_TRIALS trial_result · 2021-09-01Clinical Trial Update: An Open Label Study of Multiple Doses of Cannabidiol in the Prevention of Acute Graft-Versus-Host Disease (GVHD) [Phase 2]
Open-label Phase 2 trial evaluating multiple doses of cannabidiol to prevent acute graft-versus-host disease (aGVHD).
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CLINICAL_TRIALS trial_result · 2021-08-25Clinical Trial Update: Basiliximab Combined With Ruxolitinib as Second-line Treatment of Grade 3-4 Steroid-resistant aGVHD [Phase 4]
Phase 4 trial evaluating basiliximab with ruxolitinib as second-line treatment for grade 3-4 steroid-resistant acute graft-versus-host disea…
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CLINICAL_TRIALS trial_result · 2021-08-18Clinical Trial Update: An Open-Label Study of Defibrotide for the Prevention of Acute Graft-versus-Host-Disease (AGvHD) [Phase 2]
Phase 2 open-label study assessing defibrotide for the prevention of acute graft-versus-host disease completed with posted results.
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CLINICAL_TRIALS trial_result · 2021-08-04Clinical Trial Update: T-Guard as Treatment for Steroid Refractory Acute GVHD (BMT CTN 1802) [Phase 3]
Phase 3 trial of T-Guard (Xenikos) for steroid-refractory acute graft-versus-host disease was terminated; results are posted.