Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Obinutuzumab in cGVHD After Allogeneic Peripheral Blood Stem Cell Transplantation [Phase 2]
A Phase 2 study evaluating obinutuzumab for chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation ha…
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation [NA]
This clinical trial update reports the safety and performance results of the ARGOS-IO System used during Boston Keratoprosthesis implantatio…
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CLINICAL_TRIALS trial_result · 2025-02-12Clinical Trial Update: Extracorporeal Photopheresis for Acute Graft Versus Host Disease [Phase 2, Phase 3]
A phase 2/phase 3 trial evaluating extracorporeal photopheresis for acute graft-versus-host disease has completed.
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: Novel BET Inhibitor PLX51107 for Steroid-Refractory Acute GVHD [Phase 1, Phase 2]
Phase 1/2 trial of the BET inhibitor PLX51107 for steroid-refractory acute graft-versus-host disease was terminated; results have been poste…
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CLINICAL_TRIALS trial_result · 2025-01-28Clinical Trial Update: Measurements of Resting Energy Expenditure in Patients With or at Risk of Developing Graft Versus Host Disease
This clinical trial update reports on measurements of resting energy expenditure in patients with or at risk of developing graft-versus-host…
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CLINICAL_TRIALS trial_result · 2025-01-27Clinical Trial Update: GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease [Phase 2, Phase 3]
GRAVITAS-309 evaluated itacitinib with corticosteroids as initial therapy for chronic graft-versus-host disease; the Phase 2/3 trial was ter…
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CLINICAL_TRIALS trial_result · 2025-01-22Clinical Trial Update: Front Line Ibrutinib Without Corticosteroids for Newly Diagnosed Chronic Graft-versus-Host Disease [Phase 2]
A Phase 2 trial evaluating frontline ibrutinib without corticosteroids for newly diagnosed chronic graft-versus-host disease has completed. …
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CLINICAL_TRIALS trial_result · 2025-01-16Clinical Trial Update: Acalabrutinib in CLL and MCL Patients Subjected to Allogeneic Hematopoietic Stem Cell Transplantation (alloSCT) [Phase 2]
Phase 2 trial evaluating acalabrutinib in patients with chronic lymphocytic leukemia and mantle cell lymphoma after allogeneic stem cell tra…
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CLINICAL_TRIALS trial_result · 2025-01-07Clinical Trial Update: Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation [Phase 1]
Phase 1 trial update on adoptive immunotherapy using activated marrow-infiltrating lymphocytes with cyclophosphamide for GVHD prophylaxis in…
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CLINICAL_TRIALS trial_result · 2024-12-13Clinical Trial Update: Ibrutinib and Rituxan for Chronic GVHD [Phase 2]
Phase 2 trial of combination therapy with ibrutinib and rituximab for chronic graft-versus-host disease has been terminated with results pos…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Efficacy and Safety of KD025 in Subjects With cGVHD After At Least 2 Prior Lines of Systemic Therapy [Phase 2]
Phase 2 trial evaluating KD025 for chronic graft-versus-host disease after at least two prior systemic therapies was terminated, with effica…
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: 18-FLT PET/MR Imaging to Predict Graft Failure and GVHD in Bone Marrow Transplant Patients [EARLY_Phase 1]
An early Phase 1 trial evaluates 18-FLT PET/MR imaging to predict graft failure and graft-versus-host disease in bone marrow transplant pati…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: Prevention of Severe Acute Graft-versus-host Disease in Adult Patients Using a daGOAT Model [Phase 2]
Phase 2 trial completed evaluating a daGOAT model for preventing severe acute graft-versus-host disease in adult transplant patients.
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CLINICAL_TRIALS trial_result · 2024-12-03Clinical Trial Update: Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD [Phase 1, Phase 2]
A Phase 1/2 trial evaluating fecal microbiota transplantation with ruxolitinib and steroids as upfront treatment for severe acute intestinal…
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CLINICAL_TRIALS trial_result · 2024-11-27Clinical Trial Update: A Phase 1/2 Study to Evaluate Axatilimab in Participants With Active cGVHD [Phase 1, Phase 2]
Results from a Phase 1/2 study of Axatilimab in participants with active chronic graft-versus-host disease have been posted; the trial has c…
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CLINICAL_TRIALS trial_result · 2024-11-13Clinical Trial Update: SHR0302 and Steroid As First Line Therapy for Chronic GVHD [EARLY_Phase 1]
An early-phase clinical trial evaluating SHR0302 with steroids as first-line therapy for chronic graft-versus-host disease has completed.
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease [Phase 1, Phase 2]
Phase 1/2 study evaluating pharmacokinetics, activity, and safety of ruxolitinib in pediatric patients with Grade II-IV acute graft-versus-h…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: A Study of Itacitinib for the Treatment of Chronic Graft Versus Host Disease (cGVHD) [Phase 2]
A Phase 2 trial evaluating itacitinib for chronic graft-versus-host disease was terminated, with results posted in 2024.
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: Prevention of Severe Acute Graft-versus-host Disease in Pediatric Patients Using a daGOAT Model [Phase 2]
Phase 2 clinical trial investigating prevention of severe acute graft-versus-host disease in pediatric transplant patients using a daGOAT mo…
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CLINICAL_TRIALS trial_result · 2024-10-29Clinical Trial Update: Glasdegib for Chronic Graft-Versus-Host Disease [Phase 1, Phase 2]
A Phase 1/2 clinical trial update reports termination of the glasdegib study for chronic graft-versus-host disease (and fasciitis) with resu…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD) [Phase 2]
A Phase 2 study of axatilimab at three doses in chronic graft-versus-host disease has posted results; the trial is currently active but not …
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CLINICAL_TRIALS trial_result · 2024-10-02Clinical Trial Update: Comparing Cyclophosphamide and Abatacept With Standard of Care Treatment Following Stem Cell Transplantation [Phase 2]
Phase 2 trial comparing cyclophosphamide plus abatacept with standard of care after allogeneic stem cell transplantation for graft-versus-ho…
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Neihulizumab for Standard-Risk Acute Graft Versus Host Disease (GVHD) [Phase 1]
This update reports the completion of a Phase 1 trial evaluating Neihulizumab for standard-risk acute graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: Ruxolitinib and Steroid As First Line Therapy for Acute GVHD [Phase 2]
Phase 2 trial evaluating ruxolitinib in combination with a steroid as first-line therapy for acute graft-versus-host disease has been termin…
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CLINICAL_TRIALS trial_result · 2024-09-20Clinical Trial Update: Outcomes of Cutaneous T-Cell Lymphoma and Graft-Versus-Host Disease With Extracorporeal Photopheresis Treatment
This completed clinical trial (NCT01460914) reports outcomes of extracorporeal photopheresis treatment for cutaneous T-cell lymphoma and gra…