Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2020-08-20Clinical Trial Update: Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD [Phase 2]
Phase 2 trial evaluating selective depletion of CD45RA+ T cells from allogeneic peripheral blood stem cell grafts to prevent GVHD; study ter…
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CLINICAL_TRIALS trial_result · 2020-06-17Clinical Trial Update: Abatacept as GVHD Prophylaxis Phase 2 [Phase 2]
Phase 2 study evaluating abatacept as prophylaxis for graft-versus-host disease showed results for preventing GVHD in transplant patients; r…
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CLINICAL_TRIALS trial_result · 2020-05-15Clinical Trial Update: GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease [Phase 3]
Final results from GRAVITAS-301, a Phase 3 study evaluating itacitinib plus corticosteroids versus placebo plus corticosteroids for acute gr…
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CLINICAL_TRIALS trial_result · 2020-04-17Clinical Trial Update: Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD [Phase 2]
Phase II trial investigating natalizumab plus prednisone for initial therapy of acute GI graft-versus-host disease has completed with result…
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CLINICAL_TRIALS trial_result · 2020-04-09Clinical Trial Update: Sirolimus as Primary Therapy for the Treatment of Chronic Graft Versus Host Disease [Phase 2]
Phase 2 trial evaluating sirolimus as primary therapy for chronic graft-versus-host disease.
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CLINICAL_TRIALS trial_result · 2020-04-02Clinical Trial Update: Treatment of Newly Diagnosed Moderate or Severe Chronic Graft-versus-host Disease With Prednisone and Everolimus [Phase 2]
Phase 2 trial update on treating newly diagnosed moderate to severe chronic graft-versus-host disease with prednisone and everolimus.
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CLINICAL_TRIALS trial_result · 2020-03-12Clinical Trial Update: Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHD [Phase 2]
Phase 2 trial update on biomarkers in acute graft-versus-host disease and the use of extracorporeal photopheresis added to investigator-chos…
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CLINICAL_TRIALS trial_result · 2020-03-10Clinical Trial Update: Maraviroc as GVHD Prophylaxis in Transplant Recipients [Phase 1, Phase 2]
This clinical trial update reports termination of a study evaluating maraviroc for GVHD prophylaxis in transplant recipients, with results p…
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CLINICAL_TRIALS trial_result · 2020-01-31Clinical Trial Update: Tocilizumab for Treatment of Steroid Refractory Acute Graft-versus-Host Disease [Phase 1, Phase 2]
Clinical trial updates for tocilizumab in steroid-refractory acute graft-versus-host disease (Phase 1/Phase 2) has terminated with results p…
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CLINICAL_TRIALS trial_result · 2020-01-30Clinical Trial Update: Study of BEGEDINA® vs "Conventional Treatment" for Treating Steroid-Resistant Acute GvHD [Phase 3]
A Phase 3 trial comparing BEGEDINA with conventional treatment for steroid-resistant acute graft-versus-host disease was terminated; results…
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CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant [Phase 1, Phase 2]
A combined Phase 1/Phase 2 trial evaluating mycophenolate mofetil with cyclosporine to reduce graft-versus-host disease in patients undergoi…
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CLINICAL_TRIALS trial_result · 2020-01-06Clinical Trial Update: Phase 1/2 Study of Carfilzomib for the Prevention of Relapse and GVHD in Allo-HCT for Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating carfilzomib to prevent relapse and graft-versus-host disease in allogeneic stem cell transplant for hema…
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CLINICAL_TRIALS trial_result · 2020-01-03Clinical Trial Update: Panobinostat (LBH589): Acute Graft Versus Host Disease (aGVHD) Prevention [Phase 2]
Phase 2 clinical trial update on panobinostat (LBH589) for prevention of acute graft-versus-host disease (aGVHD) after transplant; study com…
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CLINICAL_TRIALS trial_result · 2019-12-17Clinical Trial Update: A Study to Evaluate Steroid-free Treatment for Standard-Risk aGVHD (BMT CTN 1501) [Phase 2]
Phase 2 trial evaluating a steroid-free treatment for standard-risk acute graft-versus-host disease has been completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-12-16Clinical Trial Update: Pharmacokinetics of Posaconazole (Noxafil®) as Prophylaxis for Invasive Fungal Infections [Phase 4]
Phase 4 clinical trial update reporting pharmacokinetics of posaconazole (Noxafil) when used as prophylaxis for invasive fungal infections i…
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CLINICAL_TRIALS trial_result · 2019-12-13Clinical Trial Update: Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer [Phase 2]
Phase 2 clinical trial evaluating chemotherapy, radiation therapy, and Umbilical Cord Blood Transplantation for hematologic cancers complete…
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CLINICAL_TRIALS trial_result · 2019-10-29Clinical Trial Update: Extracorporeal Photopheresis (ECP) With Methoxsalen for Chronic Graft Versus Host Disease (cGVHD) [EARLY_Phase 1]
Early phase 1 trial investigating extracorporeal photopheresis with methoxsalen for chronic graft-versus-host disease has completed and post…
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CLINICAL_TRIALS trial_result · 2019-10-23Clinical Trial Update: Intravenous Administration of RGI-2001 in Patient Undergoing Allogenic Hematopoietic Stem Cell Transplantation (AHSCT) [Phase 1, Phase 2]
Phase 1/2 clinical trial investigating intravenous administration of RGI-2001 for graft-versus-host disease in patients undergoing allogenic…
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CLINICAL_TRIALS trial_result · 2019-10-17Clinical Trial Update: Bone Marrow Transplantation in Treating Patients With Hematologic Cancer [Phase 4]
Phase 4 clinical trial update on bone marrow transplantation for hematologic cancers, including conditions such as anemia and graft-versus-h…
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CLINICAL_TRIALS trial_result · 2019-08-26Clinical Trial Update: Dose Finding Study of Vedolizumab for GvHD in Participants Undergoing Allogeneic HSCT [Phase 1]
Phase 1 dose-finding study of vedolizumab for graft-versus-host disease in participants undergoing allogeneic hematopoietic stem cell transp…
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CLINICAL_TRIALS trial_result · 2019-08-20Clinical Trial Update: A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1) [Phase 2]
Phase 2 trial evaluating ruxolitinib in combination with corticosteroids for steroid-refractory acute graft-versus-host disease has complete…
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CLINICAL_TRIALS trial_result · 2019-08-14Clinical Trial Update: Continuous Alloreactive T Cell Depletion and Regulatory T Cell Expansion for the Treatment of Steroid-refractory or Dependent Chronic GVHD [Phase 2]
Phase 2 clinical trial evaluating continuous alloreactive T cell depletion and regulatory T cell expansion for steroid-refractory or depende…
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CLINICAL_TRIALS trial_result · 2019-07-11Clinical Trial Update: Study of the Bruton's Tyrosine Kinase Inhibitor in Subjects With Chronic Graft Versus Host Disease [Phase 1, Phase 2]
Phase 1/2 study of a Bruton's Tyrosine Kinase inhibitor in subjects with chronic graft-versus-host disease has completed with results posted…
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CLINICAL_TRIALS trial_result · 2019-05-24Clinical Trial Update: A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) [Phase 2]
Phase 2 dose-finding study assessing vedolizumab for steroid-refractory acute intestinal graft-versus-host disease in patients who underwent…
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CLINICAL_TRIALS trial_result · 2019-05-01Clinical Trial Update: Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids [Phase 1, Phase 2]
Phase 1/2 trial investigating early treatment of acute graft-versus-host disease with bone marrow-derived mesenchymal stem cells plus cortic…