Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications (PHOEBUS Trial) [Phase 2]
Phase 2 clinical trial update on oral pooled fecal microbiotherapy to prevent complications after allogeneic hematopoietic cell transplantat…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG [Phase 3]
Phase 3 randomized trial comparing post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prophylaxis…
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: Analysis of Intestinal Defensin Expression in Acute GVHD
A completed University of Freiburg trial analyzes intestinal defensin expression in acute graft-versus-host disease. The study also relates …
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Abatacept for the Prevention of Graft-Versus-Host Disease (GVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating high-dose post-transplant cyclophosphamide combined with bortezomib and abatacept to prevent graft-versu…
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CLINICAL_TRIALS research · 2024-12-12Clinical Trial Update: Decidua Stroma Cells for Steroid Resistent Acute Graft-versus-host Disease After Allo-HSCT [Phase 2]
A Phase 2 clinical trial evaluating decidua stromal cells for steroid-resistant acute graft-versus-host disease after allogeneic HSCT is cur…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
A recruiting clinical trial from the University of Turin investigates cell-free DNA profiling as a tool to monitor clinically relevant event…
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CLINICAL_TRIALS research · 2024-11-27Clinical Trial Update: Tissue-resident Immune Cell Subsets in aGVHD
A clinical trial from Nanfang Hospital/Southern Medical University is investigating tissue-resident immune cell subsets in acute graft-versu…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: MORPHEE : Mechanisms of Cell Death Induced by Extracorporeal Photochemotherapy [NA]
ClinicalTrials.gov entry MORPHEE investigates mechanisms of cell death induced by extracorporeal photochemotherapy, with conditions includin…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Posaconazole Tablet As Primary Prophylaxis of HSCT Patients with Gastrointestinal GVHD
A clinical trial is evaluating posaconazole tablets as primary prophylaxis against invasive fungal disease in hematopoietic stem cell transp…
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CLINICAL_TRIALS research · 2024-11-06Clinical Trial Update: A Phase I/II Trial of VUM02 Injection for Steroid-refractory Acute Graft-versus-host Disease (SR-aGvHD) Treatment [Phase 1, Phase 2]
A Phase I/II clinical trial of VUM02 injection for steroid-refractory acute graft-versus-host disease is planned, with status not yet recrui…
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CLINICAL_TRIALS research · 2024-10-17Clinical Trial Update: MaaT013 As Salvage Therapy in Ruxolitinib Refractory GI-aGVHD Patients [Phase 3]
Phase 3 clinical trial evaluating MaaT013 as salvage therapy for ruxolitinib-refractory gastrointestinal acute graft-versus-host disease; th…
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CLINICAL_TRIALS research · 2024-09-25Clinical Trial Update: A Clinical Study of Bacillus Coagulans in Acute Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation [NA]
This clinical trial update describes a study of Bacillus coagulans for acute graft-versus-host disease following hematopoietic stem cell tra…
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CLINICAL_TRIALS research · 2024-08-30Clinical Trial Update: Ixazomib in the Prophylaxis of Chronic Graft-versus-host Disease. [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating ixazomib for prophylaxis of chronic graft-versus-host disease after hematopoietic stem cell transplantat…
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Comparison of Different Dose of Anti-T Lymphocyte Globulin (ATLG) in Haploidentical HSCT for GVHD Prophylaxis [Phase 3]
A Phase 3 clinical trial evaluating different doses of anti-T lymphocyte globulin (ATLG) for graft-versus-host disease prophylaxis in haploi…
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CLINICAL_TRIALS research · 2024-07-08Clinical Trial Update: Low-dose Cyclophosphamide or CNI in the Prevention of Acute Graft-versus-host Disease After gDLI [NA]
A clinical trial is evaluating whether low-dose cyclophosphamide or a calcineurin inhibitor can prevent acute graft-versus-host disease afte…
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CLINICAL_TRIALS research · 2024-05-29Clinical Trial Update: Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT [NA]
This update describes an ongoing pediatric trial comparing TCRαβ-depleted haploidentical hematopoietic stem cell transplantation with tradit…
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CLINICAL_TRIALS research · 2024-05-13Clinical Trial Update: Safety and Efficacy of Treg Cell in the Treatment of GVHD [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and efficacy of regulatory T cell therapy for graft-versus-host disease, currently not recr…
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CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function [Phase 2]
This clinical trial update describes a Phase 2 study evaluating infusion of mesenchymal stem cells as treatment for steroid-resistant acute …
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CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: Minitransplants With HLA-matched Donors : Comparison Between 2 GVHD Prophylaxis Regimens [Phase 2]
Phase 2 clinical trial update comparing two graft-versus-host disease prophylaxis regimens in minitransplants with HLA-matched donors for he…
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CLINICAL_TRIALS research · 2024-04-26Clinical Trial Update: Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This clinical trial update describes a cohort study investigating serum metabolic markers and early complications after allogeneic hematopoi…
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CLINICAL_TRIALS research · 2019-10-21Clinical Trial Update: Nutrition and Outcomes of Hematopoietic Cell Transplantation (HCT)
A completed clinical trial investigating nutrition and outcomes after hematopoietic cell transplantation, including allogeneic stem cell tra…
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CLINICAL_TRIALS research · 2019-02-19Clinical Trial Update: Toward Immune Biomarkers for Tolerance and GvHD in Humans
This clinical trial update describes ongoing research on immune biomarkers aimed at tolerance and preventing graft-versus-host disease in hu…
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CLINICAL_TRIALS research · 2019-02-12Clinical Trial Update: Donor Lymphocyte Infusion After Stem Cell Transplant in Treating Patients With Haematological Cancers [Phase 2]
This clinical trial update describes a Phase 2 study evaluating donor lymphocyte infusion after stem cell transplant for hematologic cancers…
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CLINICAL_TRIALS research · 2018-07-30Clinical Trial Update: Expansion of Invariant NKT Cells for a Cell Immunotherapeutic Approach Allowing the Control of Graft Versus Host-disease and Preserving the Graft Versus Leukemia Effect After Allogeneic Hematopoietic Stem Cell Transplantation
This clinical trial update describes expanding invariant natural killer T (iNKT) cells as a cell therapy to control graft-versus-host diseas…
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CLINICAL_TRIALS research · 2018-06-14Clinical Trial Update: Cognitive Function and Patient-Reported Quality of Life Outcomes Investigation in Patients Taking Vorinostat
Completed clinical trial assessing cognitive function and patient-reported quality of life in patients taking vorinostat, with outcomes rela…