Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Safety, PK, PD, Dosing, and Efficacy of RLS-0071for the Treatment of Hospitalized Patients With Steroid-Refractory Acute Graft-versus-Host Disease [Phase 2]
Phase 2 clinical trial evaluating safety, PK/PD, dosing, and efficacy of RLS-0071 for hospitalized patients with steroid-refractory acute gr…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: BPC2001 for the Prevention of Acute Graft-Versus-Host Disease Following Haploidentical Stem Cell Transplantation [Phase 2]
A Phase 2 clinical trial evaluating BPC2001 for preventing acute graft-versus-host disease after haploidentical stem cell transplantation is…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study
The PQRST study aims to predict the quality of response to treatments in patients with chronic graft-versus-host disease and is currently re…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
Indiana University is conducting a study to determine how common hypoesthesia-related keratitis is in patients with ocular graft-versus-host…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: IS-free Treg HaploHCT [Phase 1]
A Phase 1 clinical trial at Dana-Farber Cancer Institute evaluating an IS-free regulatory T cell haploidentical hematopoietic cell transplan…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients
A clinical trial evaluating Parametric Response Mapping as a way to detect chronic lung injury in hematopoietic cell transplant recipients; …
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant [Phase 2]
Phase 2 trial evaluating a two-step anti-thymocyte globulin (ATG) regimen to prevent acute graft-versus-host disease after myeloablative all…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: Expanded Access of Axatilimab to Treat a Single Patient With Chronic Graft Versus Host Disease (GVHD)
This document reports expanded access of axatilimab to treat a single patient with chronic graft-versus-host disease (GVHD). It provides sta…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: HCMV-miRNA Monitoring After Allogeneic Hematopoietic Stem Cell Transplantation Using PSTM-qPCR
A clinical trial update describing a study on monitoring HCMV using PSTM-qPCR after allogeneic hematopoietic stem cell transplantation; the …
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Treatment of Refractory cGVHD by Donor-derived Treg Cell Injection Combined With Recombinant Human Interleukin-2 [EARLY_Phase 1]
This EARLY_PHASE1 clinical trial from Shanghai General Hospital evaluates a combination of donor-derived regulatory T cell injections and re…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Study of Gecacitinib in the Treatment of Acute Graft-Versus-Host Disease After Failure of Ruxolitinib-containing Second-line Therapy [Phase 2]
Phase 2 clinical trial evaluating Gecacitinib for acute graft-versus-host disease after failure of ruxolitinib-containing second-line therap…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Clinical Observation on the Efficacy of Patient-Donor Derived Probiotics in Improving Intestinal Flora Disorder in Patients With Intestinal Acute Graft-Versus-Host Disease (aGVHD) [NA]
This clinical trial update describes an observational study evaluating patient-donor derived probiotics to improve intestinal flora in patie…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Study of Gecacitinib-corticosteroid as First-line Therapy for Grade II-IV Acute Graft Versus Host Disease [Phase 2]
Phase 2 trial evaluating gecacitinib with a corticosteroid as first-line therapy for grade II-IV acute graft-versus-host disease; status is …
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Ruxolitinib Plus Etanercept vs Ruxolitinib for Steroid-Refractory Severe Acute GVHD [NA]
A clinical trial investigating ruxolitinib plus etanercept versus ruxolitinib alone for steroid-refractory severe acute graft-versus-host di…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Photopheresis in GvHD After Hematopoietic Transplantation: Characteristics of the Procedure and of the Cell Product
A clinical trial update describing extracorporeal photopheresis for graft-versus-host disease after hematopoietic stem cell transplantation,…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Treatment Of Steroid-Refractory Acute Graft-versus-host Disease With Mesenchymal Stromal Cells Versus Best Available Therapy [Phase 3]
A Phase 3 trial is evaluating mesenchymal stromal cells versus best available therapy for steroid-refractory acute graft-versus-host disease…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Vitamin A Supplementation in Allogeneic Stem Cell Transplantation. [Phase 2]
A phase 2 clinical trial evaluating vitamin A supplementation in allogeneic stem cell transplantation is currently recruiting. The study lis…
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: A PMS of Jakavi® in Patients With Steroid-Refractory Graft-versus-Host Disease (SR-GvHD) in Korea
This is a post-marketing surveillance study in Korea evaluating Jakavi (ruxolitinib) for steroid-refractory graft-versus-host disease, and i…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Anti-CD25 rhMAb for aGVHD Prevention in High-Risk Adults Using the daGOAT Model [Phase 2]
Phase 2 trial is recruiting to evaluate an anti-CD25 recombinant human monoclonal antibody for prevention of acute graft-versus-host disease…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Tissue Immune Landscape of Graft Versus Host Disease After Allogeneic Stem Cell Transplantation (TIL-GVHD) [NA]
Clinical trial entry for the Tissue Immune Landscape of Graft Versus Host Disease After Allogeneic Stem Cell Transplantation (TIL-GVHD), spo…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell Transplant [NA]
Clinical trial update on high-dose vitamin A to prevent gastrointestinal graft-versus-host disease in allogeneic hematopoietic stem cell tra…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease [Phase 1]
A Phase 1 clinical trial update on Leflunomide for steroid-dependent chronic graft-versus-host disease. The study is currently active but no…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies [Phase 1]
A Phase 1 trial is evaluating leflunomide in combination with steroids for acute graft-versus-host disease after donor stem cell transplanta…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: Effect of Stem Cell Infusion Time on aGVHD in Patients With Nonmalignant Hematologic Diseases [Phase 3]
A Phase 3 clinical trial is investigating whether the timing of stem cell infusion affects the development of acute graft-versus-host diseas…