Glioblastoma
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent. [Phase 1]
A Phase 1 dose-finding study of Lu-177 DOTATATE for glioblastoma evaluating combination with standard of care in newly diagnosed disease and…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients [Phase 2]
A Phase 2 clinical trial evaluating a hemp-derived cannabidiol product for anxiety in glioblastoma patients was terminated, and the results …
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells [Phase 1]
Phase 1 clinical trial update for E-SYNC, a CAR T cell therapy using a synNotch EGFRvIII trigger to drive anti-EphA2/IL-13Ralpha2 CAR expres…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Impact of Androgen Signaling on the Composition of the Immune Microenvironment in Glioblastomas [NA]
This clinical trial update explores how androgen signaling influences the immune cell composition within glioblastoma tumors; the study is c…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Testing Ramipril to Prevent Memory Loss in People With Glioblastoma [Phase 2]
A Phase 2 trial evaluating ramipril to prevent memory loss in glioblastoma patients undergoing radiotherapy has completed enrollment and pos…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas [Phase 1]
A Phase 1 clinical trial evaluating the combination of BGB-290 with temozolomide in patients with IDH1/IDH2-mutant gliomas, including gliobl…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS) [NA]
A clinical trial evaluating neuromodulation to prehabilitate cortical function in patients with high-grade glioma near motor pathways, using…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma [Phase 3]
Phase 3 trial EF-41/KEYNOTE D58 evaluating Optune with temozolomide and pembrolizumab for newly diagnosed glioblastoma is currently recruiti…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma [Phase 2]
A Phase 2 clinical trial is evaluating the safety and efficacy of Pumitamig (BNT327) in patients with recurrent glioblastoma; recruitment is…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion [EARLY_Phase 1]
A Phase 1 study assessing lorlatinib for newly diagnosed high-grade gliomas with ALK or ROS1 fusions; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating the addition of AZD1390 to radiation therapy for newly diagnosed pediatric high-grade gliomas, including diffuse …
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms [Phase 2]
A Phase 2 clinical trial evaluating Fluoroethyltyrosine for the evaluation of intracranial neoplasms, including low-grade glioma and recurre…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma [Phase 1]
Clinical trial update for a Phase 1 study of a personalized neoantigen DNA vaccine in combination with retifanlimab PD-1 blockade for newly …
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CLINICAL_TRIALS trial_result · 2026-03-10Clinical Trial Update: Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma [Phase 1]
A Phase 1 study by UC Davis evaluated systemic and local lidocaine levels during glioblastoma surgery; the trial is completed.
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Glioblastoma Radiotherapy Using IMRT or Proton Beams [NA]
A clinical trial is recruiting to compare radiotherapy approaches—intensity-modulated radiotherapy (IMRT) and proton beam therapy—for gliobl…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients [Phase 3]
A Phase 3 clinical trial is planned to evaluate advanced imaging techniques for evaluating the tumor immune microenvironment in glioblastoma…
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma [Phase 1]
Phase 1 clinical trial update for an IL-8 receptor-modified CD70 CAR T cell therapy in adults with glioblastoma. The study is currently acti…
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma [EARLY_Phase 1]
Clinical trial update announcing an EARLY Phase 1 study of niraparib for newly diagnosed glioblastoma and recurrent glioma; the trial status…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac [Phase 1]
Phase 1 clinical trial exploring safe intensification of hypofractionated glioblastoma treatment on an MR-Linac; currently not yet recruitin…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients [EARLY_Phase 1]
AZD1390 is being studied in an early-phase trial for recurrent and newly diagnosed WHO grade 4 gliomas (glioblastoma/high-grade glioma), wit…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM) [Phase 1]
Phase 1 study evaluating RNA-Lipid Particle vaccines for recurrent glioblastoma; the trial is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4 [NA]
A clinical trial evaluating magnetic resonance-guided adaptive radiotherapy using an MR-Linac for high-grade gliomas is currently recruiting…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: LY3214996 Plus Abemaciclib in Recurrent Glioblastoma Patients [EARLY_Phase 1]
Early-phase trial update reports completion of a Phase 1 study evaluating LY3214996 in combination with abemaciclib for recurrent glioblasto…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG) [Phase 1]
This is a Phase 1 clinical trial update for the investigational drug FZ-AD005 in patients with high-grade glioma, including diffuse midline …
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients [EARLY_Phase 1]
An early-phase clinical trial update evaluating ribociclib (LEE011) in preoperative glioblastoma and meningioma patients.