Glioblastoma
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: F18 Fluciclovine PET/CT in Assessing Tumor Volume and Radiation Therapy Response in Patients With Glioblastoma Undergoing Surgery [NA]
A completed clinical trial evaluating F18 fluciclovine PET/CT to measure tumor volume and response to radiation therapy in glioblastoma pati…
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CLINICAL_TRIALS trial_result · 2024-09-27Clinical Trial Update: Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study)
The PRaM-GBM clinical trial in glioblastoma has completed, providing an update on the study and its aim to predict sites of tumor progressio…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma [Phase 2]
This Phase 2 trial evaluating bevacizumab with temozolomide in older patients with newly diagnosed glioblastoma or gliosarcoma has completed…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Phase I/IIa Study of Cerebraca Wafer Plus Adjuvant Temozolomide (TMZ) in Patients With Recurrent High Grade Glioma [Phase 1, Phase 2]
This document reports the completion of a Phase I/IIa clinical trial evaluating Cerebraca Wafer in combination with adjuvant temozolomide fo…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG [Phase 1, Phase 2]
Completed Phase 1/Phase 2 trial in children with relapsed high-grade glioma evaluating autologous dendritic cells with metronomic cyclophosp…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Combined Cytotoxic and Immune-Stimulatory Therapy for Glioma [Phase 1]
A Phase 1 clinical trial evaluating a combined cytotoxic and immune-stimulatory therapy for malignant glioma, including glioblastoma, has co…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma [NA]
A completed feasibility trial evaluating the Modified Atkins Ketogenic Diet for newly diagnosed malignant glioma, including glioblastoma. Re…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Correlation Between Prostate-specific Membrane Antigen Positron Emission Tomography and Arterial Spin Labeling Perfusion Imaging in Glioblastoma
A completed clinical trial from Lanzhou University Second Hospital investigates the relationship between PSMA-PET imaging and arterial spin …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM [NA]
This clinical trial investigates using a surgical tissue flap to bypass the blood-brain barrier in glioblastoma. The study is currently acti…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) [NA]
This clinical trial update indicates recruitment for a study evaluating omental tissue autograft in patients with recurrent glioblastoma mul…
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0 [EARLY_Phase 1]
This entry notes the completion of an early-phase trial evaluating sacituzumab govitecan in glioblastoma.
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Dendritic Cell Vaccine for Patients With Brain Tumors [Phase 2]
Phase 2 trial of an autologous dendritic cell vaccine for brain tumors has completed enrollment and assessment.
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Study of Pembrolizumab Plus SurVaxM for Glioblastoma at First Recurrence [Phase 2]
Phase 2 trial evaluating pembrolizumab plus SurVaxM for recurrent glioblastoma has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM) [Phase 1, Phase 2]
A terminated Phase 1/2 trial evaluating vorinostat, isotretinoin, and temozolomide in adults with recurrent glioblastoma and anaplastic glio…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM) [Phase 1]
Phase 1 trial update for CM93 in EGFR-modified recurrent glioblastoma; study status is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: CT Perfusion in the Prognostication of Cerebral High Grade Glioma [NA]
Clinical trial update indicating completion of a study evaluating CT perfusion as a prognostic tool for high-grade glioma (glioblastoma).
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CLINICAL_TRIALS trial_result · 2024-08-20Clinical Trial Update: Clinical Study on the Safety and Efficacy of Novel Oncolytic Virus in the Treatment of Recurrent Malignant Glioma [Phase 1, Phase 2]
Clinical trial update indicates a Phase 1/2 study of a novel oncolytic virus for recurrent malignant glioma (including glioblastoma) has bee…
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CLINICAL_TRIALS trial_result · 2024-08-16Clinical Trial Update: Open-Label Pilot Study of OPTUNE® With High Density Transducer Arrays for the Treatment of Recurrent GBM [Phase 2]
This document reports the completion of an open-label Phase 2 pilot study evaluating the OPTUNE TTFields device with high-density transducer…
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CLINICAL_TRIALS trial_result · 2024-08-12Clinical Trial Update: [18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers [Phase 1]
Phase 1 trial evaluating the PET tracer [18F]DASA-23 for PKM2 expression in intracranial neoplasms and glioblastoma, including healthy volun…
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: TTField in Combination With Temozolomide and Tislelizumab in The Treatment of Newly Diagnosed Glioblastoma. [Phase 2]
Phase 2 trial evaluating tumor treating fields in combination with temozolomide and tislelizumab for newly diagnosed glioblastoma. The curre…
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors [Phase 2]
Phase 2 pediatric brain tumor trial evaluating MRI-guided laser heat ablation to disrupt the peritumoral blood-brain barrier in order to imp…
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CLINICAL_TRIALS trial_result · 2024-08-07Clinical Trial Update: Repurposed Drugs in Research for Cancer Clinical Trials- Pitavastatin [EARLY_Phase 1]
An early-phase study evaluated repurposed pitavastatin for glioblastoma in adults, including recurrent disease; the EARLY_PHASE1 trial is co…
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CLINICAL_TRIALS trial_result · 2024-08-05Clinical Trial Update: Methylation Patterns of the NUPR1, MGMT, NDRG2, and GLI1 Genes and Their Impact on Therapeutic Outcome of GBM Patients
A completed clinical trial investigated methylation of NUPR1, MGMT, NDRG2, and GLI1 genes in glioblastoma patients. The study assessed how t…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Glioblastoma Psychosocial Support Program [NA]
A clinical trial evaluating a glioblastoma psychosocial support program has completed.
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CLINICAL_TRIALS trial_result · 2024-07-26Clinical Trial Update: A Study of CC-90010 in Combination With Temozolomide With or Without Radiation Therapy in Participants With Newly Diagnosed Glioblastoma [Phase 1]
This update indicates the Phase 1 study of CC-90010 in combination with temozolomide, with or without radiation therapy, for newly diagnosed…