Gastrointestinal Stromal Tumors
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CLINICAL_TRIALS trial_result · 2026-07-28Clinical Trial Results: Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) [Phase 2]
Phase 2 clinical trial results for temozolomide in advanced SDH-mutant/deficient gastrointestinal stromal tumors have been completed and res…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: The Efficacy and Safety of Temozolomide in SDH-deficient GIST [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy and safety of temozolomide in SDH-deficient gastrointestinal stromal tumors and is curre…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Development of a Multimodal AI System for GIST Management
Completed clinical trial evaluating a multimodal AI system for managing gastrointestinal stromal tumors (GIST) and related gastric condition…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Gastrointestinal Stromal Tumors
Expanded access for bezuclastinib to be coadministered with sunitinib for patients with Gastrointestinal Stromal Tumors has been announced b…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Imatinib TDM in GIST [Phase 2]
A Phase 2 clinical trial is recruiting to evaluate therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumors.
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Integrated Cancer Repository for Cancer Research
A University of Nebraska-sponsored clinical trial update indicates the Integrated Cancer Repository for Cancer Research is currently recruit…
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CLINICAL_TRIALS trial_result · 2026-01-20Clinical Trial Update: A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101) [Phase 1]
Phase 1 study CHAPTER-GIST-101 is evaluating pimitespib in combination with imatinib for gastrointestinal stromal tumors; the trial is curre…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy
University of Chicago is recruiting for a tissue procurement study across multiple cancers in patients undergoing surgery or biopsy to colle…
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: A Study of Avelumab In Combination With Axitinib in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumor After Failure of Standard Therapy [Phase 2]
Phase 2 study evaluating the combination of avelumab and axitinib in unresectable or metastatic gastrointestinal stromal tumors after failur…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST [Phase 2]
This clinical trial update describes a Phase 2 study evaluating ctDNA-guided therapy with sunitinib and regorafenib for gastrointestinal str…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Observational Registry Data on GIST Patients
An observational registry study in Taiwan is enrolling patients with gastrointestinal stromal tumors to collect registry data on clinical ch…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: TARGETed Therapy Drug MONITOring in DIGestive Oncology [NA]
UNICANCER-sponsored clinical trial is recruiting a targeted therapy monitoring study in digestive oncology, including metastatic colorectal …
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CLINICAL_TRIALS trial_result · 2025-03-03Clinical Trial Update: A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST) [Phase 2]
Phase 2 study of ripretinib (DCC-2618) in patients with advanced gastrointestinal stromal tumors has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating CGT9486 (PLX9486) as a single agent and in combination with PLX3397 (pexidartinib) or sunitinib in parti…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics [NA]
Clinical trial registry entry describing an ongoing targeted-agent evaluation in digestive cancers in China based on molecular characteristi…
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CLINICAL_TRIALS trial_result · 2024-08-19Clinical Trial Update: Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment [Phase 2]
A Phase 2 rollover protocol study of nilotinib for patients with Gastrointestinal Stromal Tumors has completed, and the trial results have b…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: Evaluate the Efficacy and Safety of Radiotherapy Combined With Ripretinib in the Treatment of Unresectable Advanced GIST [NA]
Clinical trial investigating the combination of radiotherapy with Ripretinib for unresectable advanced gastrointestinal stromal tumors is cu…
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CLINICAL_TRIALS trial_result · 2024-06-05Clinical Trial Update: A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) [Phase 1, Phase 2]
The Phase 1/2 study of the investigational drug THE-630 in advanced Gastrointestinal Stromal Tumors was terminated, with results posted on 2…
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CLINICAL_TRIALS trial_result · 2024-02-15Clinical Trial Update: DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST) [Phase 1]
A Phase 1 clinical trial update for DS-6157a in advanced gastrointestinal stromal tumors has been terminated with results posted.
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib [Phase 3]
Phase 3 trial comparing famitinib to sunitinib in advanced GIST after imatinib failure; study terminated.
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CLINICAL_TRIALS trial_result · 2024-02-08Clinical Trial Update: Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study [Phase 4]
Phase 4 trial update on allowing access to nilotinib for patients already receiving nilotinib in a Novartis-sponsored study; study status co…
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CLINICAL_TRIALS trial_result · 2024-01-05Clinical Trial Update: Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) [Phase 3]
Phase 3 trial evaluating whether continuing versus interrupting imatinib after 3 years of adjuvant therapy improves outcomes in patients wit…
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EMA withdrawal · 2023-10-19EMA Withdrawn: Imatinib Koanaa (imatinib mesilate) — Koanaa Healthcare GmbH
The EMA status shows Imatinib Koanaa (imatinib mesilate) has been withdrawn from the market by Koanaa Healthcare GmbH.
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CLINICAL_TRIALS trial_result · 2023-04-27Clinical Trial Update: A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumor [Phase 1, Phase 2]
Phase 1/2 clinical trial updating the study of CS3007 in patients with gastrointestinal stromal tumors has completed.
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CLINICAL_TRIALS trial_result · 2023-03-27Clinical Trial Update: Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST [Phase 2]
A Phase 2 study assessing regorafenib as a single agent in first-line treatment of metastatic/unresectable KIT/PDGFR wild-type gastrointesti…