Gastrointestinal Stromal Tumors
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CLINICAL_TRIALS trial_result · 2023-03-27Clinical Trial Update: Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST) [Phase 1, Phase 2]
An update on a phase 1/2 trial evaluating selinexor as a single agent and in combination with imatinib for metastatic and/or unresectable ga…
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CLINICAL_TRIALS trial_result · 2023-02-01Clinical Trial Update: Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST) [Phase 3]
Phase 3 trial of masitinib in first-line treatment for gastrointestinal stromal tumors was terminated.
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CLINICAL_TRIALS trial_result · 2023-01-04Clinical Trial Update: A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTs [Phase 2]
Phase 2 trial assessing intermittent dosing of imatinib in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumor…
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CLINICAL_TRIALS trial_result · 2023-01-03Clinical Trial Update: PDR001 Plus Imatinib for Metastatic or Unresectable GIST [Phase 1, Phase 2]
Phase 1/2 trial of PDR001 plus imatinib in metastatic or unresectable gastrointestinal stromal tumors completed.
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CLINICAL_TRIALS trial_result · 2021-06-25Clinical Trial Update: Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumors [Phase 1, Phase 2]
Phase 1/2 trial evaluating everolimus in combination with imatinib in gastrointestinal stromal tumors refractory or resistant to imatinib ha…
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CLINICAL_TRIALS trial_result · 2021-06-22Clinical Trial Update: (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors [Phase 1]
Phase 1 trial update for BLU-285 in gastrointestinal stromal tumors and other relapsed/refractory solid tumors; results posted after complet…
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CLINICAL_TRIALS trial_result · 2021-04-23Clinical Trial Update: Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies [Phase 3]
Phase 3 study evaluating DCC-2618 (ripretinib) vs placebo in advanced gastrointestinal stromal tumor patients previously treated with antica…
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CLINICAL_TRIALS trial_result · 2020-12-08Clinical Trial Update: Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib [Phase 3]
Phase 3 trial assessing masitinib in gastrointestinal stromal tumors after progression on imatinib has completed.
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CLINICAL_TRIALS trial_result · 2020-01-09Clinical Trial Update: Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs [Phase 2]
Phase II study results update for continuous dosing of regorafenib in patients with gastrointestinal stromal tumors (GISTs).
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CLINICAL_TRIALS trial_result · 2020-01-07Clinical Trial Update: Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib [Phase 2]
Phase 2 clinical trial evaluating paclitaxel in patients with metastatic or advanced gastrointestinal stromal tumors after failure of imatin…
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CLINICAL_TRIALS trial_result · 2019-07-19Clinical Trial Update: MITIGATE-NeoBOM: A Study to Evaluate 68Ga- NeoBOMB1 in Patients With Advanced TKI-treated GIST Using PET/CT [Phase 1, Phase 2]
A development-stage clinical trial evaluating 68Ga-NeoBOMB1 in advanced, TKI-treated gastrointestinal stromal tumors using PET/CT has comple…
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EMA withdrawal · 2018-10-09EMA Withdrawn: Imatinib Teva B.V. (imatinib mesilate) — Teva B.V.
EMA withdrew the Imatinib Teva B.V. product (imatinib mesilate) from the market.
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CLINICAL_TRIALS research · 2018-08-02Clinical Trial Update: The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib [Phase 4]
A Phase 4 study assessing how esomeprazole, a proton pump inhibitor, affects the bioavailability of regorafenib.
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CLINICAL_TRIALS trial_result · 2018-03-12Clinical Trial Update: A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor [Phase 2]
A Phase 2 clinical trial evaluating sunitinib in young patients with advanced gastrointestinal stromal tumors has completed with results pos…
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CLINICAL_TRIALS withdrawal · 2017-10-12Clinical Trial Update: SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor) [Phase 2]
Phase 2 trial SARC029 evaluating trametinib plus pazopanib in Gastrointestinal Stromal Tumor has been withdrawn.
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CLINICAL_TRIALS trial_result · 2017-06-22Clinical Trial Update: Phase II Study Aiming to Evaluate the Efficacy and Safety of Nilotinib Patients With Gastrointestinal Stromal Tumors (GIST) Resistant or Intolerant to Imatinib and or to 2nd Line Tyrosine Kinas (TK) Inhibitor [Phase 2]
This is a completed Phase II trial assessing the efficacy and safety of nilotinib in patients with gastrointestinal stromal tumors that are …
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CLINICAL_TRIALS trial_result · 2017-05-10Clinical Trial Update: Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib [Phase 2]
This document provides an update on a Phase 2 trial of pazopanib in advanced gastrointestinal stromal tumors refractory to imatinib and suni…
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CLINICAL_TRIALS trial_result · 2017-04-14Clinical Trial Update: The Oncopanel Pilot (TOP) Study
The Oncopanel Pilot (TOP) Study status is listed as completed in this ClinicalTrials.gov update. The update enumerates several cancer indica…
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinib [Phase 2]
This Phase 2 trial evaluates the efficacy and safety of AMN107 (nilotinib) in patients with gastrointestinal stromal tumors who progressed a…
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CLINICAL_TRIALS withdrawal · 2016-12-09Clinical Trial Update: Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
The clinical trial NCT02488746 evaluating endoscopic full thickness resection of gastric subepithelial tumors (FROST) has been terminated.
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CLINICAL_TRIALS trial_result · 2016-11-01Clinical Trial Update: Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib. [Phase 3]
A Phase 3 trial evaluating nilotinib in adults with gastrointestinal stromal tumors resistant to imatinib and sunitinib has completed and po…
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CLINICAL_TRIALS trial_result · 2016-10-21Clinical Trial Update: Special Investigation For Gist Of Sunitinib Malate (Regulatory Post Marketing Commitment Plan).
Clinical trial update for a post-marketing commitment study of sunitinib malate in gastrointestinal stromal tumors has completed with result…
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CLINICAL_TRIALS withdrawal · 2016-08-16Clinical Trial Update: Regorafenib in Subjects With Gastrointestinal Stromal Tumors (GIST) Who Have Progressed After Standard Therapy (Managed Access Program)
The Bayer-managed access program for regorafenib in gastrointestinal stromal tumors (GIST) that progressed after standard therapy is no long…
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CLINICAL_TRIALS trial_result · 2016-04-26Clinical Trial Update: Post Marketing Surveillance Study To Observe Safety And Efficacy Of Sutene
A post-marketing surveillance study evaluating the safety and efficacy of Sutene in patients with gastrointestinal stromal tumors; the study…
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CLINICAL_TRIALS trial_result · 2016-03-17Clinical Trial Update: Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST) [Phase 3]
Phase 3 clinical trial assessing the detection of circulating free DNA in patients with Gastrointestinal Stromal Tumors has completed.