Gastrointestinal Stromal Tumor
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Sign up freeTop drugs studied for this disease
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EMA approval · 2026-08-27EMA Authorised: Qinlock (ripretinib) — Deciphera Pharmaceuticals (Netherlands) B.V.
Qinlock (ripretinib) has been authorised in the EU for gastrointestinal stromal tumors, with orphan medicinal product designation.
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EMA approval · 2026-08-04EMA Authorised: Qinlock (ripretinib) — Deciphera Pharmaceuticals (Netherlands) B.V.
Qinlock (ripretinib) has been authorised in the EU for gastrointestinal stromal tumors (GIST).
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments [Phase 2]
Phase 2 randomized multicenter trial evaluating whether resuming imatinib with atezolizumab improves efficacy versus imatinib alone in unres…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Mesenteric Vascular Preconditioning Combined With Laparoscopic and Endoscopic Cooperative Surgery for Submucosal Tumor at the Gastroesophageal Junction [Phase 2]
Phase 2 clinical trial evaluating mesenteric vascular preconditioning combined with laparoscopic and endoscopic cooperative surgery for subm…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) [Phase 2, Phase 3]
This clinical trial update covers NB003 for advanced Gastrointestinal Stromal Tumor (GIST) and notes that Phase 2/Phase 3 studies are not ye…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
A clinical trial update describing a study on surgical approaches for Gastrointestinal Stromal Tumors, including tumor modeling and genomic …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015) [Phase 2]
This Phase 2 trial update covers belzutifan (MK-6482) for advanced pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, von Hip…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator [Phase 4]
Phase 4 trial extension allowing access to imatinib for patients currently on imatinib in a Novartis-sponsored study who are judged by inves…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: PH 2 Pemigatinib in SDH-deficient GIST [Phase 2]
Phase 2 study of pemigatinib in SDH-deficient gastrointestinal stromal tumor is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting [Phase 2]
Kumquat Biosciences is conducting a Phase 2 trial evaluating KQB198 in combination with imatinib as first-line therapy for advanced or metas…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors [Phase 1]
Novartis' Phase 1 dose-finding trial of TNO155 in adults with advanced solid tumors has been terminated. No efficacy results are provided in…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for Inlexisertib (DCC-3116) in combination with anticancer therapies in participants with advanced maligna…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST) [Phase 2]
A Phase 2 clinical trial update on rogaratinib (BAY 1163877) for FGFR1-4-altered advanced sarcoma and SDH-deficient gastrointestinal stromal…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Long-term Survivorship Challenges of Advanced/Metastatic GIST Patients Responding to Tyrosine Kinase Inhibitor Treatment: an Observational Study
This clinical trials entry describes an observational study assessing long-term survivorship challenges in patients with advanced or metasta…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Study of HQP1351 in Patients With GIST or Other Solid Tumors [Phase 1]
A Phase 1 clinical trial of HQP1351 in patients with Gastrointestinal stromal tumor and other solid tumors is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor [Phase 2]
Phase 2 clinical trial evaluating rivoceranib plus paclitaxel in people with Gastrointestinal Stromal Tumor is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: GIST Oral Paclitaxel(Liporaxel) [Phase 2]
An ongoing Phase 2 clinical trial is evaluating oral paclitaxel (Liporaxel) for gastrointestinal stromal tumors, sponsored by Asan Medical C…
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FDA approval · 2026-04-06FDA Approved: IMATINIB MESYLATE — Supplemental Application (BluePoint Laboratories)
FDA approved BluePoint Laboratories' supplemental application for Imatinib Mesylate (ANDA 212773), approving a generic version of the cancer…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib. [Phase 2]
A Phase 2 trial evaluating paclitaxel in gastrointestinal stromal tumor patients with low P-glycoprotein expression after failure of imatini…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study evaluating lenvatinib in gastrointestinal stromal tumor (GIST) patients after progres…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy [Phase 3]
A Phase 3 randomized trial evaluating IDRX-42 (GSK6042981) versus sunitinib in patients with gastrointestinal stromal tumors after imatinib …
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Neoadjuvant Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor [Phase 1]
A Phase 1 neoadjuvant trial evaluating imatinib plus fampridine in KIT-mutant Gastrointestinal Stromal Tumor is currently recruiting at the …
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors [Phase 2]
This is a Phase 2 clinical trial update for avapritinib in KIT or PDGFRA mutation-positive locally advanced or metastatic malignant solid tu…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: RCT of EFTR Versus STER for GIST Treatment [NA]
A randomized trial comparing endoscopic full-thickness resection (EFTR) versus submucosal tunneling endoscopic resection (STER) for small-si…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Safety of Robotic Surgery for GISTs at Special Anatomic Sites [NA]
An update on an ongoing clinical trial evaluating the safety of robotic surgery for gastrointestinal stromal tumors at special anatomical si…